Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Jue D, Wang"'
Autor:
Ryan Thiermann, Michael Sandler, Gursharan Ahir, John T Sauls, Jeremy Schroeder, Steven Brown, Guillaume Le Treut, Fangwei Si, Dongyang Li, Jue D Wang, Suckjoon Jun
Publikováno v:
eLife, Vol 12 (2024)
Despite much progress, image processing remains a significant bottleneck for high-throughput analysis of microscopy data. One popular platform for single-cell time-lapse imaging is the mother machine, which enables long-term tracking of microbial cel
Externí odkaz:
https://doaj.org/article/2cd10faf989a49f4bef667485c4da46e
Publikováno v:
mLife, Vol 1, Iss 2, Pp 101-113 (2022)
Abstract Antibiotics combat bacteria through their bacteriostatic (by growth inhibition) or bactericidal (by killing bacteria) action. Mechanistically, it has been proposed that bactericidal antibiotics trigger cellular damage, while bacteriostatic a
Externí odkaz:
https://doaj.org/article/2ab9b03398da40bb858a866d38690aae
Autor:
Danny K. Fung, Kaihong Bai, Jin Yang, Xiaoli Xu, David M. Stevenson, Daniel Amador-Noguez, Laixin Luo, Jue D. Wang
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Small alarmone hydrolases (SAHs) are alarmone metabolizing enzymes found in both metazoans and bacteria. In metazoans, the SAH homolog Mesh1 is reported to function in cofactor metabolism by hydrolyzing NADPH to NADH. In bacteria, SAHs are o
Externí odkaz:
https://doaj.org/article/c19b7059797f4a6eb86cb3489880e018
Autor:
Jin Yang, Brent W. Anderson, Asan Turdiev, Husan Turdiev, David M. Stevenson, Daniel Amador-Noguez, Vincent T. Lee, Jue D. Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nucleotides pppGpp and ppGpp regulate bacterial responses to nutritional and other stresses, while the potential roles of the related pGpp are unclear. Here, Yang et al. systematically identify proteins interacting with these nucleotides in Bacillus,
Externí odkaz:
https://doaj.org/article/5d87a8e50332442f93e779ac8d484d70
Autor:
Taylor B Updegrove, Jailynn Harke, Vivek Anantharaman, Jin Yang, Nikhil Gopalan, Di Wu, Grzegorz Piszczek, David M Stevenson, Daniel Amador-Noguez, Jue D Wang, L Aravind, Kumaran S Ramamurthi
Publikováno v:
eLife, Vol 10 (2021)
Hydrolysis of nucleoside triphosphates releases similar amounts of energy. However, ATP hydrolysis is typically used for energy-intensive reactions, whereas GTP hydrolysis typically functions as a switch. SpoIVA is a bacterial cytoskeletal protein th
Externí odkaz:
https://doaj.org/article/60e6f33030a8422a98d7eba95a455126
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
(p)ppGpp is a highly conserved bacterial alarmone which regulates many aspects of cellular physiology and metabolism. In Gram-positive bacteria such as B. subtilis, cellular (p)ppGpp level is determined by the bifunctional (p)ppGpp synthetase/hydrola
Externí odkaz:
https://doaj.org/article/f56971fca05d472ca386e9de72fc7958
The roles of replication-transcription conflict in mutagenesis and evolution of genome organization.
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008987 (2020)
Replication-transcription conflicts promote mutagenesis and give rise to evolutionary signatures, with fundamental importance to genome stability ranging from bacteria to metastatic cancer cells. This review focuses on the interplay between replicati
Externí odkaz:
https://doaj.org/article/b465f3cc2795484cb30c86c2d7b598f8
Autor:
Bret N. Peterson, Megan K. M. Young, Shukun Luo, Jeffrey Wang, Aaron T. Whiteley, Joshua J. Woodward, Liang Tong, Jue D. Wang, Daniel A. Portnoy
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell
Externí odkaz:
https://doaj.org/article/fda165a1b7c14027812eb73e6e1bcba5
Autor:
Brent W Anderson, Kuanqing Liu, Christine Wolak, Katarzyna Dubiel, Fukang She, Kenneth A Satyshur, James L Keck, Jue D Wang
Publikováno v:
eLife, Vol 8 (2019)
The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with its
Externí odkaz:
https://doaj.org/article/a0342011588d4272a5a29fd9a4d5eaf5
Autor:
Tippapha Pisithkul, Jeremy W. Schroeder, Edna A. Trujillo, Ponlkrit Yeesin, David M. Stevenson, Tai Chaiamarit, Joshua J. Coon, Jue D. Wang, Daniel Amador-Noguez
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Biofilms are structured communities of tightly associated cells that constitute the predominant state of bacterial growth in natural and human-made environments. Although the core genetic circuitry that controls biofilm formation in model ba
Externí odkaz:
https://doaj.org/article/531ca265dec64ba28248243c75ac6d3f