Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Judy Strickland"'
Autor:
Kimberly T. To, Judy Strickland, Emily Reinke, Alexandre Borrel, Jim Truax, Heather Maldonado, Dave Allen, Nicole Kleinstreuer
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-7 (2024)
Abstract Background Chemically induced skin sensitization, or allergic contact dermatitis, is a common occupational and public health issue. Regulatory authorities require an assessment of potential to cause skin sensitization for many chemical produ
Externí odkaz:
https://doaj.org/article/adb8f58888394cd0b2692c697f87c4c3
Autor:
Zhengxi Wei, Tuan Xu, Judy Strickland, Li Zhang, Yuhong Fang, Dingyin Tao, Anton Simeonov, Ruili Huang, Nicole C. Kleinstreuer, Menghang Xia
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Introduction: Skin sensitization, which leads to allergic contact dermatitis, is a key toxicological endpoint with high occupational and consumer prevalence. This study optimized several in vitro assays listed in OECD skin sensitization test guidelin
Externí odkaz:
https://doaj.org/article/18a1c8f0daa2490a935d7470c9a49342
Autor:
Judy Strickland, James Truax, Marco Corvaro, Raja Settivari, Joseph Henriquez, Jeremy McFadden, Travis Gulledge, Victor Johnson, Sean Gehen, Dori Germolec, David G. Allen, Nicole Kleinstreuer
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Skin sensitization testing is a regulatory requirement for safety evaluations of pesticides in multiple countries. Globally harmonized test guidelines that include in chemico and in vitro methods reduce animal use, but no single assay is recommended
Externí odkaz:
https://doaj.org/article/5e4f422fb5ef4ae9acd0e208de74e8e1
Autor:
Elijah J. Petersen, Richard Uhl, Blaza Toman, John T. Elliott, Judy Strickland, James Truax, John Gordon
Publikováno v:
Toxics, Vol 10, Iss 5, p 257 (2022)
The Electrophilic Allergen Screening Assay (EASA) has emerged as a promising in chemico method to detect the first key event in the adverse outcome pathway (AOP) for skin sensitization. This assay functions by assessing the depletion of one of two pr
Externí odkaz:
https://doaj.org/article/85985d40f778446ea602a79c798004ee
Autor:
Agnes L Karmaus, Kamel Mansouri, Kimberly T To, Bevin Blake, Jeremy Fitzpatrick, Judy Strickland, Grace Patlewicz, David Allen, Warren Casey, Nicole Kleinstreuer
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 188(1)
Regulatory agencies rely upon rodent in vivo acute oral toxicity data to determine hazard categorization, require appropriate precautionary labeling, and perform quantitative risk assessments. As the field of toxicology moves toward animal-free new a
Autor:
Joyce V B, Borba, Vinicius M, Alves, Rodolpho C, Braga, Daniel R, Korn, Kirsten, Overdahl, Arthur C, Silva, Steven U S, Hall, Erik, Overdahl, Nicole, Kleinstreuer, Judy, Strickland, David, Allen, Carolina Horta, Andrade, Eugene N, Muratov, Alexander, Tropsha
Publikováno v:
Environmental health perspectives. 130(2)
Modern chemical toxicology is facing a growing need to Reduce, Refine, and Replace animal tests (Russell 1959) for hazard identification. The most common type of animal assays for acute toxicity assessment of chemicals used as pesticides, pharmaceuti
Autor:
Joyce V.B. Borba, Vinicius M. Alves, Rodolpho C. Braga, Daniel R. Korn, Kirsten Overdahl, Arthur C. Silva, Steven U.S. Hall, Erik Overdahl, Nicole Kleinstreuer, Judy Strickland, David Allen, Carolina Horta Andrade, Eugene N. Muratov, Alexander Tropsha
Publikováno v:
Environmental Health Perspectives. 130
Autor:
Lysiane Richert, Tommy B. Andersson, Thomas Cole, David Asturiol, Ursula Müller-Vieira, Sandra Coecke, Andrew Worth, Camilla Bernasconi, Roman Liska, Judy Strickland, Iwona Wilk-Zasadna, Olavi Pelkonen, Christophe Chesne
Publikováno v:
Toxicology in Vitro
CYP enzyme induction is a sensitive biomarker for phenotypic metabolic competence of in vitro test systems; it is a key event associated with thyroid disruption, and a biomarker for toxicologically relevant nuclear receptor-mediated pathways. This pa
Autor:
Tyler Peryea, Ahsan Habib Polash, Alessandra Roncaglioni, Daniel M. Wilson, Warren Casey, Patricia Ruiz, Nathalie Alépée, Sherif Farag, Giovanna J. Lavado, Kimberley M. Zorn, Alexey V. Zakharov, Davide Ballabio, Katrina M. Waters, Risa Sayre, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Nicole Kleinstreuer, Pankaj R. Daga, Sean Ekins, Kamel Mansouri, Liguo Wang, Judy Strickland, Matthew J. Hirn, Sudin Bhattacharya, Dac-Trung Nguyen, Emilio Benfenati, Ignacio J. Tripodi, Amanda K. Parks, Garett Goh, Dennis G. Thomas, Glenn J. Myatt, Prachi Pradeep, Gergely Zahoranszky-Kohalmi, Anton Simeonov, Arthur C. Silva, Grace Patlewicz, Timothy Sheils, Stephen Boyd, Agnes L. Karmaus, Ahmed Sayed, Alex M. Clark, Todd M. Martin, Pavel Karpov, Jeffery M. Gearhart, Robert Rallo, D Allen, Charles Siegel, Zhen Zhang, Zijun Xiao, Alexander Tropsha, Stephen J. Capuzzi, Alexandru Korotcov, Carolina Horta Andrade, Noel Southall, Viviana Consonni, Igor V. Tetko, Jeremy M. Fitzpatrick, Andrew J. Wedlake, Denis Fourches, Zhongyu Wang, Vinicius M. Alves, Eugene N. Muratov, Timothy E. H. Allen, Andrea Mauri, James B. Brown, Alexandre Varnek, Yun Tang, Sanjeeva J. Wijeyesakere, Daniel P. Russo, Cosimo Toma, Christopher M. Grulke, Michael S. Lawless, Domenico Gadaleta, Paritosh Pande, Thomas Hartung, Jonathan M. Goodman, Kristijan Vukovic, Joyce V. Bastos, Daniela Trisciuzzi, Fagen F. Zhang, Domenico Alberga, Thomas Luechtefeld, Dan Marsh, Tyler R. Auernhammer, Shannon M. Bell, Xinhao Li, Brian J. Teppen, F. Lunghini, Sergey Sosnin, Hao Zhu, Feng Gao, Craig Rowlands, Tongan Zhao, R Todeschini, Valery Tkachenko, Francesca Grisoni, Hongbin Yang, Yaroslav Chushak, Maxim V. Fedorov, Heather L. Ciallella, Gilles Marcou
Publikováno v:
Environmental Health Perspectives
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
BACKGROUND: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f10be9a3f401d14e1b5653e1242ab66
https://www.repository.cam.ac.uk/handle/1810/322114
https://www.repository.cam.ac.uk/handle/1810/322114
Autor:
Rodolpho C. Braga, alves, Hall S, Judy Strickland, Alexander Tropsha, Borba Jvvb, Daniel Korn, Overdahl K, Carolina Horta Andrade, D Allen, Nicole Kleinstreuer, Overdahl E, Arthur C. Silva, Eugene N. Muratov
Since 2009, animal testing for cosmetic products has been prohibited in Europe, and in 2016, US EPA announced their intent to modernize the so-called "6-pack" of acute toxicity tests (acute oral toxicity, acute dermal toxicity, acute inhalation toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b04737e394094af4efb9a5977067261f
https://doi.org/10.26434/chemrxiv.13283930.v1
https://doi.org/10.26434/chemrxiv.13283930.v1