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Akademický článek

Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines.

Autor: Denise L Driscoll, Arijit Chakravarty, Doug Bowman, Vaishali Shinde, Kerri Lasky, Judy Shi, Tricia Vos, Bradley Stringer, Ben Amidon, Natalie D'Amore, Marc L Hyer

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111060 (2014)

Plk1 is a checkpoint protein whose role spans all of mitosis and includes DNA repair, and is highly conserved in eukaryotes from yeast to man. Consistent with this wide array of functions for Plk1, the cellular consequences of Plk1 disruption are div

Externí odkaz: https://doaj.org/article/befff1e4e1864bba8da1d18b3d6cc52f

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TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Publikováno v: Cancer Research Communications. 2:489-502

Oncology therapies targeting the immune system have improved patient outcomes across a wide range of tumor types, but resistance due to an inadequate T-cell response in a suppressive tumor microenvironment (TME) remains a significant problem. New the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f15976fac4916e2a443db60d3b3b36d
https://doi.org/10.1158/2767-9764.crc-21-0161

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Supplementary Methods SM1 from TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Supplementary methods and results: The supplementary methods describe: 1) the chemical synthesis and characterization of TAK-676, inclusive of TAK-676 chemical structure, purification chromatogram and NMR characterization; 2) details regarding STING

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931bb15e27a36d43a39bd54192992a77
https://doi.org/10.1158/2767-9764.22544573

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Data from TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba8980eb34badc6a19f61bbce026e67
https://doi.org/10.1158/2767-9764.c.6550691

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Supplementary Tables S1-S3 from TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Supplementary tables: Supplementary Table 1 describes where cells were obtained from and details of authentication and mycoplasma testing dates. Supplementary Table 2 shows TAK-676 potency in cynomolgus monkey, human, mouse, and rat STING via time-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc816185704d6e9271927a182bdb34f
https://doi.org/10.1158/2767-9764.22544570

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Supplementary Figures S1-S5 from TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Supplementary figures: Supplementary Figure 1 shows cell viability of human monocyte-derived dendric cells and mouse bone marrow dendritic cells. Supplementary Figure 2 shows mean plasma and tumor concentration-time curves of TAK-676 in BALB/C mice (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f557c397f065d58fee34ecc2828d809
https://doi.org/10.1158/2767-9764.22544576

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Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug–drug interaction profiles

Autor: Cindy Q. Xia, Chao Li, John K. Fallon, Mingxiang Liao, Marc L. Hyer, Judy Shi, Robert J. Griffin, Bei Ching Chuang, Pu Shi, Philip C. Smith

Publikováno v: Xenobiotica. 48:1173-1183

1. Red blood cell (RBC) partitioning is important in determining pharmacokinetic and pharmacodynamic properties of a compound; however, active transport across RBC membranes is not well understood, particularly without transporter-related cell membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadb4d5b2b555b28b83f005c096a3f65
https://doi.org/10.1080/00498254.2017.1397812

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Akademický článek

Registry-based study in people with cystic fibrosis and an R117H variant treated with ivacaftor

Autor: Meng Liu, Daniel Campbell, Nataliya Volkova, Mark Higgins, Alexander Elbert, Thalia Farietta, Josh Ostrenga, Judy Shih

Publikováno v: BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)

Background Ivacaftor approval was extended to people with cystic fibrosis (CF) and an R117H variant in 2014 in the USA. This observational, real-world, postapproval study evaluated long-term outcomes among people with CF and an R117H variant on ivaca

Externí odkaz: https://doaj.org/article/6bd56cce452446fd8d53300612a46644

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The effectiveness of blended online learning courses at the community college level

Autor: Julia H. Kaufman, Sarah Ryan, Judy Shi, Joel B. Greenhouse, Ruicong She

Publikováno v: Community College Journal of Research and Practice. 40:285-298

Whether through the use of online-only or hybrid/blended formats, colleges and universities across the country are increasingly utilizing online platforms as a medium for the delivery of instruction. At the same time, we know little about how student

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f5f66d644beaf920d3130e6ab1bf707
https://doi.org/10.1080/10668926.2015.1044584

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