Bidirectional Risk Modulator and Modifier Variant of Dilated and Hypertrophic Cardiomyopathy in BAG3.

Autor: Park J; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Department of Medicine, Weill Cornell Medicine, NewYork-Presbyterian Hospital, New York., Levin MG; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Zhang D; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Reza N; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Mead JO; Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus., Carruth ED; Department of Genomic Health, Geisinger, Danville, Pennsylvania., Kelly MA; Department of Genomic Health, Geisinger, Danville, Pennsylvania., Winters A; Autism and Developmental Medicine Institute, Geisinger, Danville, Pennsylvania., Kripke CM; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Judy RL; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania., Damrauer SM; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania.; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Owens AT; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Bastarache L; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Kinnamon DD; Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus., Hershberger RE; Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus.; Division of Cardiovascular Medicine, Department of Internal Medicine, and the Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus., Ritchie MD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia., Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Publikováno v: JAMA cardiology [JAMA Cardiol] 2024 Nov 13. Date of Electronic Publication: 2024 Nov 13.

Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias.

Autor: Weng LC; Cardiovascular Research Center (L.-C.W.), The Broad Institute of MIT and Harvard, Cambridge.; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA., Khurshid S; Demoulas Center for Cardiac Arrhythmias (S. Khurshid, P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge., Hall AW; Gene Regulation Observatory (A.W.H.), The Broad Institute of MIT and Harvard, Cambridge., Nauffal V; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA., Morrill VN; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA (Y.V.S.).; VA Atlanta Healthcare System, Decatur, GA (Y.V.S., P.W.F.W.)., Rämö JT; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Finland (J.T.R., A.P.)., Beer D; Heart Institute (D.B., C.M.H.), Geisinger, Danville, PA., Lee S; Icahn School of Medicine at Mount Sinai, New York, NY (S.L., G.N.)., Nadkarni G; Icahn School of Medicine at Mount Sinai, New York, NY (S.L., G.N.)., Johnson R; Victor Chang Cardiac Research Institute (R.J., R.S., D.F.), Darlinghurst, NSW.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW, Australia (R.J., R.S., B.W., D.F.)., Andreasen L; Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (L.A., J.P.H., J.H.S., M.S.O.).; Department of Biomedical Sciences (L.A., M.S.O.), University of Copenhagen, Denmark., Clayton A; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (A.C., H.T.M., S. Knight, M.J.C.)., Pullinger CR; Cardiovascular Research Institute and Department of Physiological Nursing (C.R.P.), University of California, San Francisco., Yoneda ZT; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (Z.T.Y., M.B.S.)., Friedman DJ; Division of Cardiology, Department of Medicine (D.J.F., N.A.N., S.H.S.), Duke University School of Medicine, Durham, NC., Hyman MC; Division of Cardiac Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia (M.C.H.)., Judy RL; Department of Surgery (R.L.J.), University of Pennsylvania, Philadelphia., Skanes AC; Division of Cardiology, Department of Medicine, Section of Cardiac Electrophysiology, Western University, London, ON, Canada (A.C.S., P.L.-S., H.R.K., J.D.R.)., Orland KM; Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, WI (K.M.O., L.L.E.)., Jordà P; Montreal Heart Institute Research Center and Faculty of Medicine, Université de Montréal, QC, Canada (P.J., M.-P.D., J.-C.T., R.T.)., Treu TM; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA., Oetjens MT; Autism and Developmental Medicine Institute, Geisinger, Lewisburg, PA (M.T.O., R.K.L.)., Subbiah R; Victor Chang Cardiac Research Institute (R.J., R.S., D.F.), Darlinghurst, NSW.; St Vincent's Hospital (R.S., B.W., D.F.), Darlinghurst, NSW.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW, Australia (R.J., R.S., B.W., D.F.)., Hartmann JP; Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (L.A., J.P.H., J.H.S., M.S.O.)., May HT; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (A.C., H.T.M., S. Knight, M.J.C.)., Kane JP; Cardiovascular Research Institute (J.P.K.), University of California, San Francisco.; Department of Medicine, Department of Biochemistry and Biophysics (J.P.K.), University of California, San Francisco., Issa TZ; Feinberg School of Medicine, Northwestern University, Chicago, IL (T.Z.I.)., Nafissi NA; Division of Cardiology, Department of Medicine (D.J.F., N.A.N., S.H.S.), Duke University School of Medicine, Durham, NC., Leong-Sit P; Division of Cardiology, Department of Medicine, Section of Cardiac Electrophysiology, Western University, London, ON, Canada (A.C.S., P.L.-S., H.R.K., J.D.R.)., Dubé MP; Montreal Heart Institute Research Center and Faculty of Medicine, Université de Montréal, QC, Canada (P.J., M.-P.D., J.-C.T., R.T.).; Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada (M.-P.D.)., Roselli C; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (C.R.)., Choi SH; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge., Tardif JC; Montreal Heart Institute Research Center and Faculty of Medicine, Université de Montréal, QC, Canada (P.J., M.-P.D., J.-C.T., R.T.)., Khan HR; Division of Cardiology, Department of Medicine, Section of Cardiac Electrophysiology, Western University, London, ON, Canada (A.C.S., P.L.-S., H.R.K., J.D.R.)., Knight S; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (A.C., H.T.M., S. Knight, M.J.C.).; Department of Medicine, University of Utah, Salt Lake City (S. Knight)., Svendsen JH; Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (L.A., J.P.H., J.H.S., M.S.O.).; Department of Clinical Medicine (J.H.S.), University of Copenhagen, Denmark., Walker B; St Vincent's Hospital (R.S., B.W., D.F.), Darlinghurst, NSW.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW, Australia (R.J., R.S., B.W., D.F.)., Karlsson Linnér R; Autism and Developmental Medicine Institute, Geisinger, Lewisburg, PA (M.T.O., R.K.L.).; Department of Economics, Leiden Law School, Leiden University, the Netherlands (R.K.L.)., Gaziano JM; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA (J.M.G.)., Tadros R; Montreal Heart Institute Research Center and Faculty of Medicine, Université de Montréal, QC, Canada (P.J., M.-P.D., J.-C.T., R.T.)., Fatkin D; Victor Chang Cardiac Research Institute (R.J., R.S., D.F.), Darlinghurst, NSW.; St Vincent's Hospital (R.S., B.W., D.F.), Darlinghurst, NSW.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, NSW, Australia (R.J., R.S., B.W., D.F.)., Rader DJ; Division of Cardiovascular Medicine, Department of Medicine (D.J.R.), University of Pennsylvania, Philadelphia., Shah SH; Division of Cardiology, Department of Medicine (D.J.F., N.A.N., S.H.S.), Duke University School of Medicine, Durham, NC.; Duke Molecular Physiology Institute (S.H.S.), Duke University School of Medicine, Durham, NC., Roden DM; Vanderbilt University Medical Center, Nashville, TN (D.M.R.)., Marcus GM; Division of Cardiology (G.M.M.), University of California, San Francisco., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (R.J.F.L.)., Damrauer SM; Department of Surgery and Department of Genetics, Perelman School of Medicine (S.M.D.), University of Pennsylvania, Philadelphia.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.M.D.)., Haggerty CM; Heart Institute (D.B., C.M.H.), Geisinger, Danville, PA.; Department of Translational Data Science and Informatics (C.M.H.), Geisinger, Danville, PA., Cho K; VA Boston Healthcare System (L.-C.W., V.N., T.M.T., J.M.G., K.C.), Brigham and Women's Hospital, Boston, MA., Palotie A; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology, Department of Psychiatry (A.P.), The Broad Institute of MIT and Harvard, Cambridge.; The Stanley Center for Psychiatric Research & Program in Medical & Population Genetics (A.P.), The Broad Institute of MIT and Harvard, Cambridge.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Finland (J.T.R., A.P.)., Olesen MS; Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (L.A., J.P.H., J.H.S., M.S.O.).; Department of Biomedical Sciences (L.A., M.S.O.), University of Copenhagen, Denmark., Eckhardt LL; Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, WI (K.M.O., L.L.E.)., Roberts JD; Division of Cardiology, Department of Medicine, Section of Cardiac Electrophysiology, Western University, London, ON, Canada (A.C.S., P.L.-S., H.R.K., J.D.R.)., Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (A.C., H.T.M., S. Knight, M.J.C.)., Shoemaker MB; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (Z.T.Y., M.B.S.)., Wilson PWF; Department of Medicine, Emory University School of Medicine, Atlanta, GA (P.W.F.W.)., Ellinor PT; Demoulas Center for Cardiac Arrhythmias (S. Khurshid, P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; VA Atlanta Healthcare System, Decatur, GA (Y.V.S., P.W.F.W.)., Lubitz SA; Demoulas Center for Cardiac Arrhythmias (S. Khurshid, P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.; Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative (L.-C.W., S. Khurshid, V.N., V.N.M., J.T.R., C.R., S.H.C., P.T.E., S.A.L.), The Broad Institute of MIT and Harvard, Cambridge.

Publikováno v: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2024 Jun; Vol. 17 (3), pp. e004320. Date of Electronic Publication: 2024 May 28.

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.

Autor: Roychowdhury T; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA. tanmoy63@gmail.com.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA. tanmoy63@gmail.com., Klarin D; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Healthcare System, Palo Alto, CA, USA., Levin MG; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Spin JM; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Rhee YH; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Deng A; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Headley CA; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Tsao NL; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Gellatly C; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Zuber V; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College, Imperial College London, London, UK., Shen F; University of Michigan Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA., Hornsby WE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Laursen IH; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Verma SS; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA, USA., Locke AE; Regeneron Genetics Center, LLC, Tarrytown, NY, USA., Einarsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Dikilitas O; Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN, USA.; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic Rochester, Rochester, MN, USA.; Mayo Clinician Investigator Training Program, Mayo Clinic Rochester, Rochester, MN, USA., Pattee JW; University of Minnesota, Minneapolis, MN, USA., Judy RL; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Pauls-Verges F; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain., Nielsen JB; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway., Wolford BN; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Brumpton BM; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Dilmé J; Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Peypoch O; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.; Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Juscafresa LC; Vascular Surgery Department, Parc de Salut Mar-Hospital del Mar, Barcelona, Spain., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Li D; Regeneron Genetics Center, LLC, Tarrytown, NY, USA., Banasik K; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jacobsen RL; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Garcia-Barrio MT; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Zhang J; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Rasmussen LM; Department of Clinical Biochemistry, Odense University Hospital, Elite Research Centre of Individualized Medicine in Arterial Disease (CIMA), Odense, Denmark., Lee R; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Handa A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Wanhainen A; Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.; Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden., Mani K; Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden., Lindholt JS; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Elite Research Centre of Individualized Medicine in Arterial Disease (CIMA), Odense, Denmark., Obel LM; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Elite Research Centre of Individualized Medicine in Arterial Disease (CIMA), Odense, Denmark., Strauss E; Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.; Department of General and Vascular Surgery, Poznan University of Medical Sciences, Poznan, Poland., Oszkinis G; Department of General and Vascular Surgery, Poznan University of Medical Sciences, Poznan, Poland.; Department of Vascular and General Surgery, Institute of Medical Sciences, University of Opole, Opole, Poland., Nelson CP; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Saxby KL; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., van Herwaarden JA; Department of Vascular Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Camacho M; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain., Davis FM; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA., Wasikowski R; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Tsoi LC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Gudjonsson JE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Eliason JL; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA., Coleman DM; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA., Henke PK; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA., Ganesh SK; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Chen YE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Guan W; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Pankratz N; Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA., Pedersen OB; Department of Clinical Immunology, Zealand University Hospital-Køge, Køge, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Tang W; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Hveem K; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Gudbjartsson D; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Gretarsdottir S; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Ferreira MA; Regeneron Genetics Center, LLC, Tarrytown, NY, USA., Baras A; Regeneron Genetics Center, LLC, Tarrytown, NY, USA., Kullo IJ; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic Rochester, Rochester, MN, USA., Ritchie MD; Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Christensen AH; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Iversen KK; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Eldrup N; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Vascular Surgery, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Sillesen H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bundgaard H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Burgess S; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Gill D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Chief Scientific Advisor Office, Research and Early Development, Novo Nordisk, Copenhagen, Denmark., Gallagher K; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Jones GT; Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand., Bown MJ; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Tsao PS; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu., Damrauer SM; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA. damrauer@upenn.edu.; Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. damrauer@upenn.edu.; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. damrauer@upenn.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 Nov; Vol. 55 (11), pp. 1831-1842. Date of Electronic Publication: 2023 Oct 16.

Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.

Autor: Klarin D; Veterans Affairs (VA) Palo Alto Healthcare System, Palo Alto, CA, USA. dklarin@stanford.edu.; Department of Surgery, Stanford University School of Medicine, Palo Alto, CA, USA. dklarin@stanford.edu., Devineni P; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA., Sendamarai AK; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Angueira AR; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Shen YH; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA., Levin MG; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Medicine, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Pirruccello JP; Division of Cardiology, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Karnam PR; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA., Roychowdhury T; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Li Y; Division of Cardiothoracic Surgery, Michael E. 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Publikováno v: Nature genetics [Nat Genet] 2023 Jul; Vol. 55 (7), pp. 1106-1115. Date of Electronic Publication: 2023 Jun 12.

Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries.

Autor: Mishra A; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Hachiya T; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Jürgenson T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia., Namba S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Posner DC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Kamanu FK; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Koido M; Division of Molecular Pathology, Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan.; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Le Grand Q; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Shi M; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., He Y; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Georgakis MK; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA., Caro I; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Krebs K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Liaw YC; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.; Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan., Vaura FC; Department of Internal Medicine, University of Turku, Turku, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Turku, Finland., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Winsvold BS; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Srinivasasainagendra V; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Parodi L; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA., Bae HJ; Department of Neurology and Cerebrovascular Disease Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Chauhan G; Rajendra Institute of Medical Sciences, Ranchi, India., Chong MR; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada., Tomppo L; Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Akinyemi R; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Roshchupkin GV; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands., Habib N; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Jee YH; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Thomassen JQ; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Abedi V; Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, VA, USA.; Department of Public Health Sciences, College of Medicine, The Pennsylvania State University, State College, PA, USA., Cárcel-Márquez J; Stroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain., Nygaard M; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Leonard HL; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Yang C; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA., Yonova-Doing E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK., Knol MJ; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands., Lewis AJ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Judy RL; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA., Ago T; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Amouyel P; University of Lille, INSERM U1167, RID-AGE, LabEx DISTALZ, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; CHU Lille, Public Health Department, Lille, France.; Institut Pasteur de Lille, Lille, France., Armstrong ND; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Bakker MK; UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Bordes C; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Børte S; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway., Cain A; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, Saint Louis, MO, USA., Cole JW; VA Maryland Health Care System, Baltimore, MD, USA.; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA., de Jager PL; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA., de Cid R; GenomesForLife-GCAT Lab Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain., Endres M; Klinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), partner site Berlin, Berlin, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany., Ferreira LE; Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil., Geerlings MI; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Gasca NC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Hata J; Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., He J; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Heath AK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Ho YL; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Havulinna AS; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland, FIMM-HiLIFE, Helsinki, Finland., Hopewell JC; Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hyacinth HI; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Inouye M; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK., Jacob MA; Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands., Jeon CE; Los Angeles County Department of Public Health, Los Angeles, CA, USA., Jern C; Institute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden., Kamouchi M; Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Keene KL; Department of Biology, Brody School of Medicine Center for Health Disparities, East Carolina University, Greenville, NC, USA., Kitazono T; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Kittner SJ; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Neurology and Geriatric Research and Education Clinical Center, VA Maryland Health Care System, Baltimore, MD, USA., Konuma T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Kumar A; Rajendra Institute of Medical Sciences, Ranchi, India., Lacaze P; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Launer LJ; Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA., Lee KJ; Department of Neurology, Korea University Guro Hospital, Seoul, Republic of Korea., Lepik K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University Center for Primary Care and Public Health, Lausanne, Switzerland., Li J; Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, VA, USA., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Markus HS; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Marston NA; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Meitinger T; Institute of Human Genetics, Technical University of Munich, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Montellano FA; Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Morisaki T; Division of Molecular Pathology, Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan., Mosley TH; The MIND Center, University of Mississippi Medical Center, Jackson, MS, USA., Nalls MA; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Nordestgaard BG; Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., O'Donnell MJ; College of Medicine Nursing and Health Science, NUI Galway, Galway, Ireland., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan., Onland-Moret NC; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Ovbiagele B; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Peters A; Institute of Epidemiology, Helmholtz Zentrum München,, German Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilian University Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Munich, Munich, Germany., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Rosand J; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA., Sabatine MS; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sacco RL; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.; Evelyn F. McKnight Brain Institute, Gainesville, FL, USA., Saleheen D; Division of Cardiology, Department of Medicine, Columbia University, New York, NY, USA., Sandset EC; Stroke Unit, Department of Neurology, Oslo University Hospital, Oslo, Norway.; Research and Development, The Norwegian Air Ambulance Foundation, Oslo, Norway., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Sargurupremraj M; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Sasaki M; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Satizabal CL; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Framingham Heart Study, Framingham, MA, USA., Schmidt CO; University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF, Greifswald, Germany., Shimizu A; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA., Sloane KL; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Sutoh Y; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Sun YV; Atlanta VA Health Care System, Decatur, GA, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA., Tanno K; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Tiedt S; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Tatlisumak T; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Unviersity Hospital, Gothenburg, Sweden., Torres-Aguila NP; Stroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain., Tiwari HK; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Trégouët DA; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Tuladhar AM; Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands., Tybjærg-Hansen A; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., van Vugt M; Division Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Vibo R; Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia., Verma SS; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Wennberg P; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Woo D; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Wilson PWF; Atlanta VA Health Care System, Decatur, GA, USA.; Department of Medicine, Division of Cardiovascular Disease, Emory University School of Medicine, Atlanta, GA, USA., Xu H; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Yang Q; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Yoon K; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Gieger C; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Ninomiya T; Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Rostock, Germany., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands., Rissanen IL; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Strbian D; Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea., Chen PH; Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan., Mayerhofer E; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA., Howson JMM; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Adams H; Department of Clinical Genetics, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile., Wassertheil-Smoller S; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Christensen K; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands., Rundek T; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.; Evelyn F. McKnight Brain Institute, Gainesville, FL, USA., Worrall BB; Department of Neurology, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Science, University of Virginia, Charlottesville, VA, USA., Lathrop GM; McGill Genome Centre, Montreal, Quebec, Canada., Riaz M; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Simonsick EM; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Kõrv J; Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia., França PHC; Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil., Zand R; Geisinger Neuroscience Institute, Geisinger Health System, Danville, PA, USA.; Department of Neurology, College of Medicine, The Pennsylvania State University, State College, PA, USA., Prasad K; Rajendra Institute of Medical Sciences, Ranchi, India., Frikke-Schmidt R; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., de Leeuw FE; Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands., Liman T; Center for Stroke Research Berlin, Berlin, Germany.; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Klinik für Neurologie, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany., Haeusler KG; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Ruigrok YM; UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Heuschmann PU; Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.; Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany.; Clinical Trial Center, University Hospital Würzburg, Würzburg, Germany., Longstreth WT; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Jung KJ; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea., Bastarache L; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Paré G; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, Michael G. 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Publikováno v: Nature [Nature] 2022 Dec; Vol. 612 (7938), pp. E7.