Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Judy M. Y. Wong"'
Autor:
Jialin Xu, Diego Madureira de Oliveira, Matthew A. Trudeau, Yang Yang, Jessica J. Y. Chin, Don D. Sin, Andrew J. Sandford, Judy M. Y. Wong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Chronic obstructive pulmonary disease (COPD) is a disorder of accelerated lung aging. Multiple pieces of evidence support that the aging biomarker short telomeres, which can be caused by mutations in telomerase reverse transcriptase (TERT),
Externí odkaz:
https://doaj.org/article/5dc636af3f594923931f1d3f6dce1de5
Autor:
Sunny Y. Yang, Pauline Lejault, Sandy Chevrier, Romain Boidot, A. Gordon Robertson, Judy M. Y. Wong, David Monchaud
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
In vivo existence of guanine-rich four-stranded RNA structures (G4-RNAs) has been a matter of debate. Here the authors developed a protocol, G4RP-seq, to capture and identify transcriptome-wide G4-RNA, providing insights into the formation of transie
Externí odkaz:
https://doaj.org/article/61b9b8ce6219493191fa70ecc98a1fde
Publikováno v:
Cancers, Vol 12, Iss 6, p 1679 (2020)
Telomerase reverse transcriptase (TERT)—the catalytic subunit of telomerase—is reactivated in up to 90% of all human cancers. TERT is observed in heterogenous populations of protein complexes, which are dynamically regulated in a cell type- and c
Externí odkaz:
https://doaj.org/article/9c1ba5a3eef04dbb935ce19d1dd02d81
Autor:
Judy M. Y. Wong, Matthew A. Trudeau, Andrew J. Sandford, Don D. Sin, Diego Madureira de Oliveira, Jialin Xu, Jessica J. Y. Chin, Yang Yang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Chronic obstructive pulmonary disease (COPD) is a disorder of accelerated lung aging. Multiple pieces of evidence support that the aging biomarker short telomeres, which can be caused by mutations in telomerase reverse transcriptase (TERT), contribut
Non-canonical Functions of Telomerase Reverse Transcriptase: Emerging Roles and Biological Relevance
Autor:
Connor A. H. Thompson, Judy M. Y. Wong
Publikováno v:
Current Topics in Medicinal Chemistry. 20:498-507
Increasing evidence from research on telomerase suggests that in addition to its catalytic telomere repeat synthesis activity, telomerase may have other biologically important functions. The canonical roles of telomerase are at the telomere ends wher
Autor:
Stephen Yip, Sunny Y. Yang, Judy M. Y. Wong, Joanne Lim, Peter C. Stirling, Emily Yun-Chia Chang, David Monchaud, Harwood H Kwan
Publikováno v:
NAR Cancer
NAR Cancer, Oxford University Press, 2021, 3, ⟨10.1093/narcan/zcab031⟩
NAR Cancer, Oxford University Press, 2021, 3, ⟨10.1093/narcan/zcab031⟩
About 10–15% of all human cancer cells employ a telomerase-independent recombination-based telomere maintenance method, known as alternative lengthening of telomere (ALT), of which the full mechanism remains incompletely understood. While implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35061cac402b1879b34577d49eaafac3
https://hal.archives-ouvertes.fr/hal-03325508/document
https://hal.archives-ouvertes.fr/hal-03325508/document
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252976 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 6 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 6 (2021)
Background Chronic hepatitis C virus infection (HCV) is a common infectious disease that affects more than 2.7 million people in the US. Because the emergency department (ED) can present an ideal opportunity to screen patients who may not otherwise g
Publikováno v:
Nature protocols. 17(3)
Guanine-rich RNAs can fold into four-stranded structures, termed G-quadruplexes (G4-RNAs), and participate in a wide range of biological processes. Here we describe in detail a G4-RNA-specific precipitation (G4RP) protocol, which enables the transcri
Autor:
Sharon A. Savage, Jialin Xu, Neelam Giri, Blanche P. Alter, Judy M. Y. Wong, Payal P. Khincha
Publikováno v:
Am J Hematol
Dyskeratosis congenita (DC) is an inherited bone marrow failure and cancer susceptibility syndrome caused by germline mutations in telomere biology genes. Germline mutations in DKC1, which encodes the protein dyskerin, cause X-linked recessive DC. Be
Autor:
Sunny Y. Yang, David Monchaud, Isaline Renard, Apolline Roux, Pauline Lejault, Marc Pirrotta, Judy M. Y. Wong, Michael Grandmougin
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2019, 47 (11), pp.5502-5510. ⟨10.1093/nar/gkz215⟩
Nucleic Acids Research, Oxford University Press, 2019, 47 (11), pp.5502-5510. ⟨10.1093/nar/gkz215⟩
International audience; Guanine-rich DNA and RNA sequences can fold into higher-order structures known as G-quadruplexes (or G4-DNA and G4-RNA, respectively). The prevalence of the G4 landscapes in the human genome, transcriptome and ncRNAome (non-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d5e7b480badd9ee69797db709386ef
https://hal.archives-ouvertes.fr/hal-02121536v2/document
https://hal.archives-ouvertes.fr/hal-02121536v2/document