Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Judy M. Suh"'
Autor:
Judy M. Suh, Sandra Frauchiger, Michael Soth, Xiaochun Han, Ronald J. Hill, Buelent Kocer, Taygerly Joshua Paul Gergely, Jaehyeon Park, Hong Jun-Bae, Andreas Kuglstatter, Rama K. Kondru, Tobias Gabriel, Renee Litman, Yan Lou, Zachary Kevin Sweeney, Mcintosh Joel, Nolan James Dewdney, Dana Davis, David Michael Goldstein, Timothy D. Owens, Hasim Zecic, Keshab Sarma
Publikováno v:
Journal of Medicinal Chemistry. 58:512-516
Structure-based drug design was used to guide the optimization of a series of selective BTK inhibitors as potential treatments for Rheumatoid arthritis. Highlights include the introduction of a benzyl alcohol group and a fluorine substitution, each o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2706725af4b785142b07ad80c3bfd24
https://doi.org/10.1021/jm500305p
https://doi.org/10.1021/jm500305p
Publikováno v:
Organic Letters. 12:4712-4715
An expedient enantioselective synthesis of the Δ(4)-oxocene cores present in (+)-laurencin and (+)-prelaureatin was accomplished in eight steps via a novel one-pot regio- and stereoselective ring cyclization-fragmentation-expansion cascade from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b33c32bd26b7c1a7ef2f98342edec1f
https://doi.org/10.1021/ol1021965
https://doi.org/10.1021/ol1021965
Autor:
Qingwu Jin, Yu Li, Jennifer Fretland, Julie Q. Hang, Dimitrio Stefanidis, Gabrielle Heilek, Hassan Javanbakht, Jeffrey Wu, Weiling Liang, Fang‐Jie Zhang, Jesper A. Jernelius, Nidhi Arora, Judy M. Suh, Petra Inbar, Michael Welch, Seth F. Harris, Klaus Klumpp, Guoping Su, Donald Roy Hirschfeld, Ralf Roetz, Armando G. Villaseñor, Keshab Sarma, Zachary Kevin Sweeney, J. Roland Billedeau, Joshua Kennedy-Smith, Mark D. Smith, James Edward Paul Davidson
Publikováno v:
ChemMedChem. 4:88-99
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are part of the preferred treatment regimens for individuals infected with HIV. These NNRTI-based regimens are efficacious, but the most popular NNRTIs have a low genetic barrier to resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454bae71e060e01fe27efb0014a6b6df
https://doi.org/10.1002/cmdc.200800262
https://doi.org/10.1002/cmdc.200800262
Autor:
Jennifer Fretland, Jeffrey Wu, Nidhi Arora, Fang‐Jie Zhang, Julie Q. Hang, Judy M. Suh, Stan Tsing, Seth F. Harris, Joshua Kennedy-Smith, Amber Paul, James Edward Paul Davidson, Sarah Sperry, J. Roland Billedeau, Mark D. Smith, Gabrielle Heilek, Klaus Klumpp, Guoping Su, Zachary Kevin Sweeney, Hassan Javanbakht, Amy S. Zhou, Taraneh Mirzadegan, Shelley K. Gleason, Yu Li, Ralf Roetz, Jesper A. Jernelius, Donald Roy Hirschfeld, Armando G. Villaseñor
Publikováno v:
Journal of Medicinal Chemistry. 51:7449-7458
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are recommended components of preferred combination antiretroviral therapies used for the treatment of HIV. These regimens are extremely effective in suppressing virus replication. Structure-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9dd621d2388ac4c08151f4728547da
https://doi.org/10.1021/jm800527x
https://doi.org/10.1021/jm800527x
Publikováno v:
The Journal of Organic Chemistry. 73:8452-8457
The synthesis of didemniserinolipid B utilizing a ketalization/ring-closing metathesis (K/RCM) strategy is described. In the course of this work, a novel 2-allyl-4-fluorophenyl auxiliary for relay ring-closing metathesis (RRCM) was developed, which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610e3da8f63def2c2aa8523cf010178e
https://doi.org/10.1021/jo801666t
https://doi.org/10.1021/jo801666t
Autor:
Renee Litman, Zachary Kevin Sweeney, Timothy D. Owens, Buelent Kocer, Andreas Kuglstatter, Hong Jun-Bae, Judy M. Suh, Xiaochun Han, Keshab Sarma, David Michael Goldstein, Taygerly Joshua Paul Gergely, Dana Davis, Yan Lou, Rama K. Kondru, Mcintosh Joel
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(2)
A rational fluorine scan based on co-crystal structures was explored to increase the potency of a series of selective BTK inhibitors. While fluorine substitution on a saturated bicyclic ring system yields no apparent benefit, the same operation on an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94bf891e5acc91f972c13f6b3fd4448
https://pubmed.ncbi.nlm.nih.gov/25466710
https://pubmed.ncbi.nlm.nih.gov/25466710
Publikováno v:
ChemInform. 40
The synthesis of didemniserinolipid B utilizing a ketalization/ring-closing metathesis (K/RCM) strategy is described. In the course of this work, a novel 2-allyl-4-fluorophenyl auxiliary for relay ring-closing metathesis (RRCM) was developed, which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75a0ecee9f2b25f569d01a21981b2bca
https://doi.org/10.1002/chin.200912201
https://doi.org/10.1002/chin.200912201
Autor:
Amy S. Zhou, Jennifer Fretland, Mark D. Smith, Y. David Saito, Anthony M. Giannetti, Julie Q. Hang, Michael Martin, Zachary Kevin Sweeney, James Patrick Dunn, Judy M. Suh, Yu Li, Klaus Klumpp, Sahaja Acharya, Gabrielle Heilek, Jeffrey Wu, Andrew J. Briggs, Ann C. Kaiser, Todd R. Elworthy, Steven Swallow
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(15)
Novel non-nucleoside inhibitors of HIV-RT that contain pyridazinone isosteres were prepared, and a series of triazolinones were found to be potent inhibitors of HIV replication. These compounds were active against several NNRTI-resistant virus strain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad89248c8409a4b85d56402d5f107a16
https://pubmed.ncbi.nlm.nih.gov/18625554
https://pubmed.ncbi.nlm.nih.gov/18625554
Publikováno v:
ChemInform. 35
The Lewis acid catalyzed cyclization of hexatrienes and pentadienals to bicyclo[3.1.0]hexenes and cyclopentenones, respectively, was investigated. The application of the former reaction to the total synthesis of photodeoxytridachione, a molluscan pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9841c1f2f8df46b63e8f442c8c66ac
https://doi.org/10.1002/chin.200410076
https://doi.org/10.1002/chin.200410076
Autor:
Jennifer Fretland, Jeffrey Wu, Donald Roy Hirschfeld, Nidhi Arora, Weiling Liang, Armando G. Villaseñor, J. Roland Billedeau, Ralf Roetz, Dennis Mitsugu Yasuda, Judy M. Suh, Mark D. Smith, Yu Li, Guoping Su, Joshua Kennedy-Smith, Seth F. Harris, Zachary Kevin Sweeney, Gabrielle Heilek, Hassan Javanbakht, Klaus Klumpp, Julie Q. Hang
Publikováno v:
MedChemComm. 1:79
New pyridone non-nucleoside reverse transcriptase inhibitors (NNRTIs) were prepared and several flexible routes to this class of inhibitor were identified. These NNRTIs were active inhibitors of the replication of wild-type and NNRTI-resistant HIV. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0bfad2599b3d01e9cca599f8dcfb4a0
https://doi.org/10.1039/c0md00009d
https://doi.org/10.1039/c0md00009d