Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Judy Logel"'
Publikováno v:
Journal of Molecular Neuroscience. 40:185-195
The alpha7 neuronal nicotinic receptor gene (CHRNA7) has been implicated in the pathophysiology of schizophrenia by genetic and pharmacological studies. Expression of the alpha7* receptor, as measured by [(125)I]alpha-bungarotoxin autoradiography, is
Autor:
Charles R. Breese, Judy Logel, Allan C. Collins, Michael J. Marks, Bernadette Sullivan, Michael J. Lee, Catherine E. Adams, Sherry Leonard, Kieron M Gillen
Publikováno v:
Neuropsychopharmacology. 23:351-364
Previous studies have suggested that an abnormality in neuronal nicotinic acetylcholine receptor expression or function may be involved in the neuropathophysiology of schizophrenia. [(3)H]-nicotine and [(3)H]-epibatidine binding were compared in post
Autor:
Robert Freedman, Carla Drebing, Judy Logel, Bette K. DeMasters, Bernadette Sullivan, Charles R. Breese, Sherry Leonard, Michelle Barnhart, Yvonne Rollins, Catherine E. Adams
Publikováno v:
The Journal of Comparative Neurology. 387:385-398
Neuronal nicotinic acetylcholine receptors are expressed in the human central nervous system. A specific subtype of this receptor family, the alpha7 nicotinic acetylcholine receptor, is thought to be the principal alpha-bungarotoxin (alphaBTX)-bindin
Publikováno v:
Journal of Molecular Neuroscience. 40:267-267
Publikováno v:
FEBS letters. 186(2)
A somatic cell mutant has been isolated which is resistant to killing and growth inhibition by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. The resistance phenotype is dominant with respect to the w
Autor:
Michael Sinensky, Judy Logel
Publikováno v:
The Journal of biological chemistry. 258(14)
Mevinolin is demonstrated to inhibit the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in Chinese hamster ovary cells. Evidence is presented that this effect of mevinolin is not general to degradation of total cellular proteins and is not d
Publikováno v:
Archives of biochemistry and biophysics. 227(1)
Decreased activities of both 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) synthase and HMG CoA reductase are observed in the presence of sterol in the Chinese hamster ovary (CHO) fibroblast. In three different genotypes of CHO cell mutants resista
Publikováno v:
Experimental cell research. 171(2)
Previous studies on a somatic cell mutant auxotrophic for mevalonate (Mev-1) have shown that these cells rapidly lose viability when deprived of mevalonic acid in culture medium supplemented with serum cholesterol. Testing of all known end products o