Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Judy L. Raucy"'
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164642 (2016)
The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and upta
Externí odkaz:
https://doaj.org/article/c7a6fb31159e441ab01667999ea53786
Autor:
Judy L. Raucy, Marija Pinne
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071615416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::561e0d9fa59cd9dcfa1a9491b6924921
https://doi.org/10.1007/978-1-0716-1542-3_9
https://doi.org/10.1007/978-1-0716-1542-3_9
Autor:
Marija Pinne, Judy L. Raucy
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071615416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76e9b29d27c12f73768e8d62603dd2a8
https://doi.org/10.1007/978-1-0716-1542-3_11
https://doi.org/10.1007/978-1-0716-1542-3_11
Autor:
Judy L. Raucy, Marija Pinne
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071615416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22822437bb23cd278553587e5db8d269
https://doi.org/10.1007/978-1-0716-1542-3_10
https://doi.org/10.1007/978-1-0716-1542-3_10
Publikováno v:
Drug metabolism letters. 11(2)
Background Nuclear Receptors (NRs), including PXR and CAR, are presumed to be ligand-dependent transcription factors, but ligand binding is not an absolute requirement for activation. Indeed, many compounds activate PXR and CAR by indirect mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78fd9e0f1491b2f410cfc2aacf688ce
https://pubmed.ncbi.nlm.nih.gov/29219065
https://pubmed.ncbi.nlm.nih.gov/29219065
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164642 (2016)
PLoS ONE
PLoS ONE
The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and upta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977f32c763c297b7eb41addf4b52e36a
http://europepmc.org/articles/PMC5061317?pdf=render
http://europepmc.org/articles/PMC5061317?pdf=render
Autor:
Jerome M. Lasker, Judy L. Raucy
Publikováno v:
Current Drug Metabolism. 11:806-814
The screening of new drug candidates for nuclear receptor activation can identify agents with the potential to produce drug-drug interactions or elicit adverse drug effects. The nuclear receptors of interest are those that control the expression of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fad668f1edeb3c3170a91b4f022251b
https://doi.org/10.2174/138920010794328896
https://doi.org/10.2174/138920010794328896
Publikováno v:
Toxicology in Vitro. 19:275-287
CYP1A is a subfamily of cytochrome P450 enzymes involved in the metabolism of numerous therapeutic drugs and in the bioactivation of procarcinogens to mutagens. Because of their diverse metabolic capacities, differences in expression of CYP1A enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdc2fdd5bb44a887034cca857a2391b
https://doi.org/10.1016/j.tiv.2004.10.003
https://doi.org/10.1016/j.tiv.2004.10.003
Publikováno v:
Drug Metabolism and Disposition. 33:38-48
Exposure to certain xenochemicals can alter the catalytic activity of the major drug-metabolizing enzyme, CYP3A4, either by enhancing expression of this cytochrome P450 or inhibiting its activity. Such alterations can result in adverse consequences s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4d85bda9b68593aa01db6d3fb44b4b
https://doi.org/10.1124/dmd.104.001594
https://doi.org/10.1124/dmd.104.001594
CONVERSION OF THE HIV PROTEASE INHIBITOR NELFINAVIR TO A BIOACTIVE METABOLITE BY HUMAN LIVER CYP2C19
Publikováno v:
Drug Metabolism and Disposition. 32:1462-1467
Antiretroviral therapy for human immunodeficiency virus (HIV) infection includes treatment with both reverse transcriptase inhibitors and protease inhibitors, which markedly suppress viral replication and circulating HIV RNA levels. Cytochrome P450 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d391d220c7f9d181dd487b188f4e3e4
https://doi.org/10.1124/dmd.104.001743
https://doi.org/10.1124/dmd.104.001743