Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Judy Dering"'
Autor:
Sara A. Hurvitz, Jennifer L. Caswell-Jin, Katherine L. McNamara, Jason J. Zoeller, Gregory R. Bean, Robert Dichmann, Alejandra Perez, Ravindranath Patel, Lee Zehngebot, Heather Allen, Linda Bosserman, Brian DiCarlo, April Kennedy, Armando Giuliano, Carmen Calfa, David Molthrop, Aruna Mani, Hsiao-Wang Chen, Judy Dering, Brad Adams, Eran Kotler, Michael F. Press, Joan S. Brugge, Christina Curtis, Dennis J. Slamon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
HER2+ breast cancer patients can often develop resistance to trastuzumab and therefore potential combination therapies need to be explored. Here, the authors report the results of a multi-center randomized phase II clinical trial evaluating the patho
Externí odkaz:
https://doaj.org/article/3ed71c9a08f44623be4704bf23a0df55
Autor:
Jason J Zoeller, Michael F Press, Laura M Selfors, Judy Dering, Dennis J Slamon, Sara A Hurvitz, Joan S Brugge
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251163 (2021)
Our previous pre-clinical work defined BCL-2 induction as a critical component of the adaptive response to lapatinib-mediated inhibition of HER2. To determine whether a similar BCL-2 upregulation occurs in lapatinib-treated patients, we evaluated gen
Externí odkaz:
https://doaj.org/article/403191507d6d430fae491ac157d03afe
Autor:
Gottfried E. Konecny, Dennis J. Slamon, Gerrit Los, Fritz Jänicke, Nitin Udar, Sugandha Dandekar, Hong-Mei Rong, Natarajan Venkatesan, Victor E. Velculescu, Siân Jones, Boris Winterhoff, Alexandra Meuter, Charles Ginther, Lee Anderson, Judy Dering, Meenal Chalukya, Kanthinh Manivong, Jing Wei Qi, Teodora Kolarova, Christine zu Eulenburg, Maike Ihnen
PDF file - 603K, Supplemental Figure S1: Gene maps of the BRCA1 (A) and BRCA2 (B) CpG islands examined with bisulfite pyrosequencing. Supplemental Figure S2: Anchorage independent growth inhibition at 1μM rucaparib in soft agar. Of the 39 tested ova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df54f80fb3880b007f62b7f6bbc31c4
https://doi.org/10.1158/1535-7163.22500252
https://doi.org/10.1158/1535-7163.22500252
Autor:
Gottfried E. Konecny, Dennis J. Slamon, Gerrit Los, Fritz Jänicke, Nitin Udar, Sugandha Dandekar, Hong-Mei Rong, Natarajan Venkatesan, Victor E. Velculescu, Siân Jones, Boris Winterhoff, Alexandra Meuter, Charles Ginther, Lee Anderson, Judy Dering, Meenal Chalukya, Kanthinh Manivong, Jing Wei Qi, Teodora Kolarova, Christine zu Eulenburg, Maike Ihnen
Here, we investigate the potential role of the PARP inhibitor rucaparib (CO-338, formerly known as AG014699 and PF-01367338) for the treatment of sporadic ovarian cancer. We studied the growth inhibitory effects of rucaparib in a panel of 39 ovarian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbeee4da3ffc16ade9b2433aa2b60aae
https://doi.org/10.1158/1535-7163.c.6536409.v1
https://doi.org/10.1158/1535-7163.c.6536409.v1
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
PDF - 69K, Supplemental Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5cc944f3707f5ad259f84b88e0f28a
https://doi.org/10.1158/1535-7163.22500510
https://doi.org/10.1158/1535-7163.22500510
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
Heat shock protein 90 (HSP90) is involved in protein folding and functions as a chaperone for numerous client proteins, many of which are important in non–small cell lung cancer (NSCLC) pathogenesis. We sought to define preclinical effects of the H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340bde653ea76e976bddef604a102046
https://doi.org/10.1158/1535-7163.c.6536484.v1
https://doi.org/10.1158/1535-7163.c.6536484.v1
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
PDF - 769K, Heat maps from microarray analyses of gene expression changes seen in at least 13 of 16 experiments after exposure to NVP-AUY922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2337f1f4ea5f861ba5a922f87b2c414c
https://doi.org/10.1158/1535-7163.22500516.v1
https://doi.org/10.1158/1535-7163.22500516.v1
Autor:
Gottfried E. Konecny, Dennis J. Slamon, Gerrit Los, Fritz Jänicke, Nitin Udar, Sugandha Dandekar, Hong-Mei Rong, Natarajan Venkatesan, Victor E. Velculescu, Siân Jones, Boris Winterhoff, Alexandra Meuter, Charles Ginther, Lee Anderson, Judy Dering, Meenal Chalukya, Kanthinh Manivong, Jing Wei Qi, Teodora Kolarova, Christine zu Eulenburg, Maike Ihnen
PDF file - 66K, Cell lines and culture media.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10249e54d733f8ff8e4066b47d2df516
https://doi.org/10.1158/1535-7163.22500249.v1
https://doi.org/10.1158/1535-7163.22500249.v1
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
PDF - 47B, A tabular demonstration of the efficacy and tolerability of NVP-AUY922 in 32 mice carrying subcutaneous A549 or H1975 xenograft tumors randomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3156a31aed59157028623a7831bffe
https://doi.org/10.1158/1535-7163.22500507
https://doi.org/10.1158/1535-7163.22500507
Autor:
Stephen Johnston, Anne-Marie Martin, Catherine Ellis, Allison Florance, Lisa O'Rourke, Judy Dering, Michael F. Press, Richard S. Finn
Purpose: Lapatinib, a dual epidermal growth factor receptor (EGFR) and HER2 inhibitor, remains unproven in non–HER2-amplified metastatic breast cancer (MBC). EGF30008, a phase III trial of letrozole and lapatinib versus letrozole and placebo, demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd56a7b20b8498705aeab2368a1044bf
https://doi.org/10.1158/1078-0432.c.6521348
https://doi.org/10.1158/1078-0432.c.6521348