Výsledky vyhledávání - "Judy C. Young"

Supplementary Figure 1 from Nonclinical Evaluation of the Serum Pharmacodynamic Biomarkers HGF and Shed MET following Dosing with the Anti-MET Monovalent Monoclonal Antibody Onartuzumab

Autor: Judy C. Young, Mark Merchant, Ihsan Nijem, Thomas Gelzleichter, Surinder Kaur, William Mallet, Mally Romero, Ellen Filvaroff, Christophe Severin, Jing Peng, Youjun Chen, Zhong Zheng, Elaine Mai

PDF file - 21K, Supplemental Figure 1. Human sMET (A) and HGF (B) levels in human plasma samples from a panel of 20 renal cell carcinoma patients and 15 normal donors were measured using the MET ECLA (A) and HGF ELISA (B), respectively.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698324299a1e8945ea2d58c1c0bc79a7
https://doi.org/10.1158/1535-7163.22499716.v1

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Supplementary Figure Legend, Table 1 from Nonclinical Evaluation of the Serum Pharmacodynamic Biomarkers HGF and Shed MET following Dosing with the Anti-MET Monovalent Monoclonal Antibody Onartuzumab

PDF file - 76K, Supplemental Table 1: Oligonucleotide sequences.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602f35b92f38a4e317349755783d4b4e
https://doi.org/10.1158/1535-7163.22499713

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Data from Afucosylated Antibodies Increase Activation of FcγRIIIa-Dependent Signaling Components to Intensify Processes Promoting ADCC

Autor: John B. Lowe, Mark X. Sliwkowski, Teemu T. Junttila, Judy C. Young, Cecile Chalouni, Scot D. Liu

Antibody-dependent cellular cytotoxicity (ADCC) is a key mechanism by which therapeutic antibodies mediate their antitumor effects. The absence of fucose on the heavy chain of the antibody increases the affinity between the antibody and FcγRIIIa, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf45524b6fa31bc7b521542edaa46420
https://doi.org/10.1158/2326-6066.c.6548686.v1

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Supplemental Figure 1 from Afucosylated Antibodies Increase Activation of FcγRIIIa-Dependent Signaling Components to Intensify Processes Promoting ADCC

Autor: John B. Lowe, Mark X. Sliwkowski, Teemu T. Junttila, Judy C. Young, Cecile Chalouni, Scot D. Liu

NK cells with high affinity FcgRIIIa also exhibit more protein tyrosine phosphorylation in response to afucosylated antibodies compared to fucosylated ones.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5451c8d73df70f515334bd2557005c4d
https://doi.org/10.1158/2326-6066.22538146

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Supplemental Figure 2 from Afucosylated Antibodies Increase Activation of FcγRIIIa-Dependent Signaling Components to Intensify Processes Promoting ADCC

Autor: John B. Lowe, Mark X. Sliwkowski, Teemu T. Junttila, Judy C. Young, Cecile Chalouni, Scot D. Liu

Approximates the amount of fucosylated antibody required to elicit similar protein tyrosine phosphorylation signaling compared to afucosylated antibodies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba6e8ed3d57f60442ba92aa3e61ad73
https://doi.org/10.1158/2326-6066.22538143

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Data from Nonclinical Evaluation of the Serum Pharmacodynamic Biomarkers HGF and Shed MET following Dosing with the Anti-MET Monovalent Monoclonal Antibody Onartuzumab

Onartuzumab, a humanized, monovalent monoclonal anti-MET antibody, antagonizes MET signaling by inhibiting binding of its ligand, hepatocyte growth factor (HGF). We investigated the effects of onartuzumab on cell-associated and circulating (shed) MET

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f35c13437b18b0d84db54fef4380a6d
https://doi.org/10.1158/1535-7163.c.6536236

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Defining the borders of the chicken proto-fps gene, a precursor of Fujinami sarcoma virus

Autor: Judy C. Young, Peter H. Duesberg, Samuel L. Pfaff, Joel S. Hayflick, Ren-Ping Zhou

Publikováno v: Virology. 146(2)

The transforming (onc) genes of retroviruses contain specific sequences, derived from as yet poorly defined, normal cellular genes, termed proto-onc genes. Proto-onc genes must be defined to explain their docility compared to the oncogenicity of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7e73fcfeb45dc00b2598a2058550f2
https://pubmed.ncbi.nlm.nih.gov/2996222

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Akademický článek

Nonclinical evaluation of the serum pharmacodynamic biomarkers HGF and shed MET following dosing with the anti-MET monovalent monoclonal antibody onartuzumab.

Autor: Mai E; Corresponding Author: Judy C. Young, Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, MS98, South San Francisco, CA 94080. jyoung@gene.com., Zheng Z, Chen Y, Peng J, Severin C, Filvaroff E, Romero M, Mallet W, Kaur S, Gelzleichter T, Nijem I, Merchant M, Young JC

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2014 Feb; Vol. 13 (2), pp. 540-52. Date of Electronic Publication: 2013 Nov 20.

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