Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Judy Barnett-Norris"'
Publikováno v:
Life Sciences. 77:1625-1639
Scientific views of cell membrane organization are presently changing. Rather than serving only as the medium through which membrane proteins diffuse, lipid bilayers have now been shown to form compartmentalized domains with different biophysical pro
Autor:
Judy Barnett-Norris, Sean D. McAllister, Mary E. Abood, Diane L. Lynch, Patricia H. Reggio, Dow P. Hurst
Publikováno v:
Journal of Biological Chemistry. 279:48024-48037
In this study, we tested the hypothesis that a CB(1) TMH3-4-5-6 aromatic microdomain, which includes F3.25(190), F3.36(201), W5.43(280), and W6.48(357), is centrally involved in CB(1) receptor activation, with the F3.36(201)/W6.48(357) interaction ke
Autor:
Diane L. Lynch, Patricia H. Reggio, Dow P. Hurst, Frank Guarnieri, R Singh, Judy Barnett-Norris
Publikováno v:
The Journal of Peptide Research. 60:357-370
The cannabinoid CB1 receptor, a member of the Rhodopsin (Rho) family of G protein coupled receptors (GPCRs), exhibits high levels of constitutive activity. In contrast, Rho exhibits an exquisite lack of constitutive activity. In Rho, W6.48(265) on tr
Autor:
Judy Barnett-Norris, Katharine W. Nowell Harmon, Qing Tao, Mary E. Abood, Dow P. Hurst, Kurt Buehner, Patricia H. Reggio, Guy A. Cabral, Frank Guarnieri, Sean D. McAllister
Publikováno v:
Biochemical Pharmacology. 63:2121-2136
Previous mutation and modeling studies have identified an aromatic cluster in the transmembrane helix (TMH) 3-4-5 region as important for ligand binding at the CB(1) and CB(2) cannabinoid receptors. Through novel mixed mode Monte Carlo/Stochastic Dyn
Autor:
Frank Guarnieri, Patricia H. Reggio, Juan A. Ballesteros, Judy Barnett-Norris, Kurt Buehner, Dow P. Hurst
Publikováno v:
International Journal of Quantum Chemistry. 88:76-86
Our modeling studies have suggested that β branched amino acids Val, lle, or Thr located (i, i + 3) or (i, i + 4) apart on an alpha helix can form a groove into which a ligand alkyl chain can fit. Experimental support forthis idea comes from the cry
Publikováno v:
Journal of Medicinal Chemistry. 41:4861-4872
The endogenous cannabinoid anandamide (N-arachidonoylethanolamide) has been shown to possess higher affinity for the cannabinoid CB1 receptor than for the CB2 receptor. Carrier-mediated transport has been proposed to be essential for the termination
Autor:
Allyn C. Howlett, Daniel Fleischer, Patricia H. Reggio, Somnath Mukhopadhyay, Sharon Anavi-Goffer, Dow P. Hurst, Mary E. Abood, Shanping Shi, Diane L. Lynch, Judy Barnett-Norris, Deborah L. Lewis
Publikováno v:
The Journal of biological chemistry. 282(34)
The intracellular C-terminal helix 8 (H8) of the CB(1) cannabinoid receptor deviates from the highly conserved NPXXY(X)(5,6)F G-protein-coupled receptor motif, possessing a Leu instead of a Phe. We compared the signal transduction capabilities of CB(
Publikováno v:
Molecular pharmacology. 68(1)
In this study, the sensitivity of the CB2 receptor to methanethiosulfonate (MTS) derivatives was tested, and a native cysteine residue conferring the sensitivity was identified. By incubating human embryonic kidney 293 cells stably transfected with C
Autor:
Sean D, McAllister, Dow P, Hurst, Judy, Barnett-Norris, Diane, Lynch, Patricia H, Reggio, Mary E, Abood
Publikováno v:
The Journal of biological chemistry. 279(46)
In this study, we tested the hypothesis that a CB(1) TMH3-4-5-6 aromatic microdomain, which includes F3.25(190), F3.36(201), W5.43(280), and W6.48(357), is centrally involved in CB(1) receptor activation, with the F3.36(201)/W6.48(357) interaction ke
Autor:
Dow P. Hurst, Diane L. Lynch, Judy Barnett-Norris, Gulrukh Rizvi, Patricia H. Reggio, Sean D. McAllister, Mary E. Abood, Sharon Anavi-Goffer
Publikováno v:
Journal of medicinal chemistry. 46(24)
The cannabinoid CB(1) receptor transmembrane helix (TMH) 3-4-5-6 region includes an aromatic microdomain comprised of residues F3.25, F3.36, W4.64, Y5.39, W5.43, and W6.48. In previous work, we have demonstrated that aromaticity at position 5.39 in C