Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Judy A Sakanari"'
Autor:
Emma L Gunderson, Ian Vogel, Laura Chappell, Christina A Bulman, K C Lim, Mona Luo, Jeffrey D Whitman, Chris Franklin, Young-Jun Choi, Emilie Lefoulon, Travis Clark, Brenda Beerntsen, Barton Slatko, Makedonka Mitreva, William Sullivan, Judy A Sakanari
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008623 (2020)
Antibiotic treatment has emerged as a promising strategy to sterilize and kill filarial nematodes due to their dependence on their endosymbiotic bacteria, Wolbachia. Several studies have shown that novel and FDA-approved antibiotics are efficacious a
Externí odkaz:
https://doaj.org/article/f89eb62492fe42fa95aecba52589d24f
Autor:
Denis Voronin, Nancy Tricoche, Shabnam Jawahar, Michael Shlossman, Christina A Bulman, Chelsea Fischer, Michael T Suderman, Judy A Sakanari, Sara Lustigman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007108 (2019)
BACKGROUND:The human filarial parasite Onchocerca volvulus is the causative agent of onchocerciasis (river blindness). It causes blindness in 270,000 individuals with an additional 6.5 million suffering from severe skin pathologies. Current internati
Externí odkaz:
https://doaj.org/article/ff04341d6ef848d4912eb1dace7391cf
Autor:
Christina A Bulman, Chelsea M Bidlow, Sara Lustigman, Fidelis Cho-Ngwa, David Williams, Alberto A Rascón, Nancy Tricoche, Moses Samje, Aaron Bell, Brian Suzuki, K C Lim, Nonglak Supakorndej, Prasit Supakorndej, Alan R Wolfe, Giselle M Knudsen, Steven Chen, Chris Wilson, Kean-Hooi Ang, Michelle Arkin, Jiri Gut, Chris Franklin, Chris Marcellino, James H McKerrow, Anjan Debnath, Judy A Sakanari
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003534 (2015)
Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, diethylcarbamazine (DEC), and albendazole are used in control programs for
Externí odkaz:
https://doaj.org/article/1872fa3e64e84c4c88486f9960a5d481
Autor:
Denis Voronin, Nancy Tricoche, Ricardo Peguero, Anna Maria Kaminska, Elodie Ghedin, Judy A. Sakanari, Sara Lustigman
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 256 (2024)
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases caused by filarial nematodes that utilize insect vectors for transmission to their human hosts. Current control strategies are based on annual or biannual mass drug administr
Externí odkaz:
https://doaj.org/article/53a95d5f5f1c4fd998ed4b21b7bca319
Autor:
Francesca Fata, Radosveta Gencheva, Qing Cheng, Rachel Lullo, Matteo Ardini, Ilaria Silvestri, Federica Gabriele, Rodolfo Ippoliti, Christina A. Bulman, Judy A. Sakanari, David L. Williams, Elias S.J. Arnér, Francesco Angelucci
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102278- (2022)
Enzymes in the thiol redox systems of microbial pathogens are promising targets for drug development. In this study we characterized the thioredoxin reductase (TrxR) selenoproteins from Brugia malayi and Onchocerca volvulus, filarial nematode parasit
Externí odkaz:
https://doaj.org/article/3ad78271ac504fecbdcd50d7a6474ac7
Autor:
Marc P. Hübner, Emma Gunderson, Ian Vogel, Christina A. Bulman, K.C. Lim, Marianne Koschel, Alexandra Ehrens, Stefan J. Frohberger, Martina Fendler, Nancy Tricoche, Denis Voronin, Andrew Steven, Victor Chi, Malina A. Bakowski, Ashley K. Woods, H. Michael Petrassi, Case W. McNamara, Brenda Beerntsen, Laura Chappell, William Sullivan, Mark J. Taylor, Joseph D. Turner, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 12, Iss , Pp 18-27 (2020)
The quinazolines CBR417 and CBR490 were previously shown to be potent anti-wolbachials that deplete Wolbachia endosymbionts of filarial nematodes and present promising pre-clinical candidates for human filarial diseases such as onchocerciasis. In the
Externí odkaz:
https://doaj.org/article/ae0698b9586a42138cd1a78a22ad6053
Autor:
Emma L. Gunderson, Clifford Bryant, Christina A. Bulman, Chelsea Fischer, Mona Luo, Ian Vogel, Kee-Chong Lim, Shabnam Jawahar, Nancy Tricoche, Denis Voronin, Christopher Corbo, Rene B. Ayiseh, Faustin P. T. Manfo, Glory E. Mbah, Fidelis Cho-Ngwa, Brenda Beerntsen, Adam R. Renslo, Sara Lustigman, Judy A. Sakanari
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 189 (2022)
Onchocerciasis and lymphatic filariasis are neglected tropical diseases caused by infection with filarial worms. Annual or biannual mass drug administration with microfilaricidal drugs that kill the microfilarial stages of the parasites has helped re
Externí odkaz:
https://doaj.org/article/47f08033f00a440f8fc6a2eb661e1414
Autor:
Liwen Feng, Sébastien Pomel, Perle Latre de Late, Alexandre Taravaud, Philippe M. Loiseau, Louis Maes, Fidelis Cho-Ngwa, Christina A. Bulman, Chelsea Fischer, Judy A. Sakanari, Peter D. Ziniel, David L. Williams, Elisabeth Davioud-Charvet
Publikováno v:
Molecules, Vol 25, Iss 21, p 5075 (2020)
Neglected parasitic diseases remain a major public health issue worldwide, especially in tropical and subtropical areas. Human parasite diversity is very large, ranging from protozoa to worms. In most cases, more effective and new drugs are urgently
Externí odkaz:
https://doaj.org/article/6570e81779b547f09e769fe57b259c76
Autor:
Matthew T. Laurie, Corin V. White, Hanna Retallack, Wesley Wu, Matthew S. Moser, Judy A. Sakanari, Kenny Ang, Christopher Wilson, Michelle R. Arkin, Joseph L. DeRisi
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Balamuthia mandrillaris is a pathogenic free-living amoeba that causes a rare but almost always fatal infection of the central nervous system called granulomatous amoebic encephalitis (GAE). Two distinct forms of B. mandrillaris—a prolifer
Externí odkaz:
https://doaj.org/article/dc0b924a0e4e4116b009021d93f76abd
Autor:
Fidelis Cho-Ngwa, Alan P. Robertson, Nick J. Koszewski, Saurabh Verma, Richard J. Martin, Smith B. Babiaka, Christina A. Bulman, Jesse P. Goff, Moses Samje, Judy A. Sakanari, Godfred A. Ayimele, Melanie Abongwa
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-15 (2021)
Parasites & Vectors
Parasites & Vectors
Background Drugs currently used for controlling onchocerciasis and lymphatic filariasis (LF) are mainly microfilaricidal, with minimal or no effect on the adult worms. For efficient management of these diseases, it is necessary to search for new drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e266ed6f437e7b3b57646d22453634b
https://doaj.org/article/ab912f354990437f95ca1f09a00a2334
https://doaj.org/article/ab912f354990437f95ca1f09a00a2334