Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Judy Lucas"'
Autor:
Wenyan Zhong, Jeremy S. Myers, Fang Wang, Kai Wang, Justin Lucas, Edward Rosfjord, Judy Lucas, Andrea T. Hooper, Sharon Yang, Lu Anna Lemon, Magali Guffroy, Chad May, Jadwiga R. Bienkowska, Paul A. Rejto
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background The clinical success of immune checkpoint inhibitors demonstrates that reactivation of the human immune system delivers durable responses for some patients and represents an exciting approach for cancer treatment. An important cla
Externí odkaz:
https://doaj.org/article/8611614a41274bc88abf31f1a71b7264
Autor:
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100279- (2021)
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjug
Externí odkaz:
https://doaj.org/article/76d0c5083adc4e25955529b3fcfbbf6d
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Effects of Systemic Administration of Free Payload Compared with Conventional HER2-vc0101 on Indicators of Bone Marrow Toxicity and Bone Marrow Payload Levels in Rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d432b6130242412350911c126917be78
https://doi.org/10.1158/1535-7163.22520919.v1
https://doi.org/10.1158/1535-7163.22520919.v1
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
The approval of ado-trastuzumab emtansine (T-DM1) in HER2+ metastatic breast cancer validated HER2 as a target for HER2-specific antibody–drug conjugates (ADC). Despite its demonstrated clinical efficacy, certain inherent properties within T-DM1 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1b894a20379dc9a76f654d4811688b
https://doi.org/10.1158/1535-7163.c.6542832
https://doi.org/10.1158/1535-7163.c.6542832
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Immunohistochemical evaluation of HER2 expression in vivo cell line and patient-derived xenograft models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3ff9f7c862c417038a9aae79602e4f
https://doi.org/10.1158/1535-7163.22520937
https://doi.org/10.1158/1535-7163.22520937
Autor:
Hans-Peter Gerber, Kim T. Arndt, Christopher J. O'Donnell, Andreas Maderna, Edmund Graziani, Judy Lucas, Mike Cinque, Kenny Sung Kyoo Kim, Kiran Khandke, Manoj B. Charati, William Hu, My-Hanh Lam, Sylvia Musto, Maximillian T. Follettie, Veronica Diesl, Fang Wang, Eugene Melamud, Jeremy S. Myers, Guixian Jin, Matthew Sung, Xingzhi Tan, Frank Loganzo
Supplementary Figures S1 to S11. Supplementary Figure S1: Schematic illustration of the approach used to create trastuzumab-maytansinoid ADC resistant cell lines. Supplementary Figure S2: Structures of payloads and ADCs. Supplementary Figure S3: 361-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79603999d612f532f7eea3bb1f02469
https://doi.org/10.1158/1535-7163.22500637.v1
https://doi.org/10.1158/1535-7163.22500637.v1
Autor:
Hans-Peter Gerber, Kim T. Arndt, Christopher J. O'Donnell, Andreas Maderna, Edmund Graziani, Judy Lucas, Mike Cinque, Kenny Sung Kyoo Kim, Kiran Khandke, Manoj B. Charati, William Hu, My-Hanh Lam, Sylvia Musto, Maximillian T. Follettie, Veronica Diesl, Fang Wang, Eugene Melamud, Jeremy S. Myers, Guixian Jin, Matthew Sung, Xingzhi Tan, Frank Loganzo
Supplementary Methods, Table S1 S2, and Figure Legends. Supplementary Table S1: Properties of cell lines made resistant to TM-conjugate. Supplementary Table S2: Relative resistance of selected free payloads and Cys-capped-released species in H69 (no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030c02d31cd9136288d63c1ed31908a5
https://doi.org/10.1158/1535-7163.22500634.v1
https://doi.org/10.1158/1535-7163.22500634.v1
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Includes Supplementary Materials and Methods, Data and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aca1bc8d20f2fe143c7aa7d3d27294
https://doi.org/10.1158/1535-7163.22520934
https://doi.org/10.1158/1535-7163.22520934
Autor:
Frank Loganzo, Hans-Peter Gerber, Judy Lucas, Edward Rosfjord, Jeremy S. Myers, Russell Dushin, Dahui Zhou, Lindsay King, Laurie Tylaska, Fang Wang, Christine Hosselet, Jonathan Golas, Bingwen Lu, Xingzhi Tan, Matthew Sung
Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate (ADC) that has demonstrated clinical benefit for patients with HER2+ metastatic breast cancer; however, its clinical activity is limited by inherent or acquired drug resistance. The molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b7849b4a80f721f9c5c51b80a5df70
https://doi.org/10.1158/1535-7163.c.6537949.v1
https://doi.org/10.1158/1535-7163.c.6537949.v1
Autor:
Hans-Peter Gerber, Robert T. Abraham, Lioudmila Tchistiakova, Christopher J. O'Donnell, George Hu, Mauricio Leal, Judy Lucas, Elana Ernstoff, Russell Dushin, Kiran Khandke, Andreas Giannakou, Bitha Narayanan, Maureen Dougher, Jonathon Golas, Kenneth G. Geles, Kimberly Marquette, John DiJoseph, Marc Damelin, Puja Sapra
PDF file-458KB, Supplementary Figure S1. Representation of A1mcMMAF and its proposed processing., Supplementary Figure S2. Chromatographic characterization of A1mcMMAF., Supplementary Figure S3. LC-MS analysis of A1mcMMAF ADC., Supplementary Figure S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab9f699b4baa5ba46a527ef133c122d
https://doi.org/10.1158/1535-7163.22498438
https://doi.org/10.1158/1535-7163.22498438