Výsledky vyhledávání

Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants

Autor: Shabir A, Madhi, Fernando P, Polack, Pedro A, Piedra, Flor M, Munoz, Adrian A, Trenholme, Eric A F, Simões, Geeta K, Swamy, Sapeckshita, Agrawal, Khatija, Ahmed, Allison, August, Abdullah H, Baqui, Anna, Calvert, Janice, Chen, Iksung, Cho, Mark F, Cotton, Clare L, Cutland, Janet A, Englund, Amy, Fix, Bernard, Gonik, Laura, Hammitt, Paul T, Heath, Joanne N, de Jesus, Christine E, Jones, Asma, Khalil, David W, Kimberlin, Romina, Libster, Conrado J, Llapur, Marilla, Lucero, Gonzalo, Pérez Marc, Helen S, Marshall, Masebole S, Masenya, Federico, Martinón-Torres, Jennifer K, Meece, Terry M, Nolan, Ayman, Osman, Kirsten P, Perrett, Joyce S, Plested, Peter C, Richmond, Matthew D, Snape, Julie H, Shakib, Vivek, Shinde, Tanya, Stoney, D Nigel, Thomas, Alan T, Tita, Michael W, Varner, Manu, Vatish, Keith, Vrbicky, Judy, Wen, Khalequ, Zaman, Heather J, Zar, Gregory M, Glenn, Louis F, Fries, Shirley, Wong

Publikováno v: The New England Journal of Medicine

Summary of study A multi-country randomized, placebo-controlled trial of the safety, immunogenicity and efficacy of respiratory syncytial virus (RSV) F-protein nanoparticle vaccine was undertaken in 4,636 pregnant women and their infants. RSV F-prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044f72715b6fa6e69a67d216cd8eb81e
https://openaccess.sgul.ac.uk/id/eprint/112223/1/nejmoa1908380.pdf

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2637. Third Trimester Immunization with an Respiratory Syncytial Virus F Protein Vaccine for the Prevention of RSV Lower Respiratory Tract Infection in Infants

Autor: Amy Fix, D. Nigel Thomas, Joyce S. Plested, Chang-Min Chen, Louis Fries, Gregory M. Glenn, Michelle Spindler, Judy Wen, Iksung Cho

Publikováno v: Open Forum Infectious Diseases

Background Respiratory syncytial virus (RSV) is the leading viral cause of severe lower respiratory tract infection (LRTI) in infants worldwide, with severe disease occurring in the first months of life. We assessed the efficacy of maternal immunizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2df0a8bd67fcc1fe7c9bcc583dc6f3
http://europepmc.org/articles/PMC6810251

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A Phase 2 randomized, observer-blind, placebo-controlled, dose-ranging trial of aluminum-adjuvanted respiratory syncytial virus F particle vaccine formulations in healthy women of childbearing age

Autor: Pedro A. Piedra, Eloi Kpamegan, D. Nigel Thomas, Allison August, Judy Wen, Gregory M. Glenn, Dewal Jani, Hanxin Lu, Louis Fries, Somia P. Hickman

Publikováno v: Vaccine. 35(30)

Objective Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants. We are developing an RSV fusion (F) protein nanoparticle vaccine for immunization of third trimester pregnant women to passively protect infants throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492919e19049a854b6ca648f9faccba7
https://pubmed.ncbi.nlm.nih.gov/28579233

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Cytokines IL-1α, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: restoration by interferon γ

Autor: Carter Van Waes, Judy Wen, Elena Leukinova, Zhong Chen, Giovana R. Thomas

Publikováno v: Cancer Immunology, Immunotherapy. 53:33-40

We previously characterized the expression of CD80 in different murine head and neck squamous cell carcinoma (HNSCC) clones derived following tumor progression in the absence of T cell-mediated immunity in severe combined immunodeficient (SCID) mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b42b2224279dda90e4c120040d7af2
https://doi.org/10.1007/s00262-003-0433-4

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The inhibitor of apoptosis protein survivin is associated with high-risk behavior of neuroblastoma

Autor: Andrew Davidoff, Shigeru Takamizawa, Anthony D. Sandler, David Scott, Judy Wen, Takeo Azuhata, Masahiro Fukuzawa

Publikováno v: Journal of Pediatric Surgery. 36:1785-1791

Background/Purpose: Apoptotic factors inducing or preventing cell death may intrinsically govern the behavior of some tumors. Survivin is a recently described member of the inhibitor of apoptosis protein (IAP) family, that is expressed in a cell cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237c77408f2555db0b7558eb219192f7
https://doi.org/10.1053/jpsu.2001.28839

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Differential apoptosis gene expression in pediatric tumors of the kidney

Autor: Shigeru Takamizawa, Anthony D. Sandler, Shinya Okamoto, Ken Kimura, Judy Wen, Warren P. Bishop

Publikováno v: Journal of Pediatric Surgery. 35:390-395

Apoptosis, or programmed cell death, is essential in maintaining normal homeostasis of tissues. The process of apoptosis is controlled by numerous pro- and antiapoptotic factors. Variations in expression of such factors may account for some variation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507442038257343b5e20a439c308654f
https://doi.org/10.1016/s0022-3468(00)90047-2

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Overexpression of Fas Ligand Does Not Confer Immune Privilege to a Pancreatic β Tumor Cell Line (βTC-3)

Autor: Anthony D. Sandler, Warren P. Bishop, Judy Wen, Ken Kimura, Shigeru Takamizawa, Shinya Okamoto

Publikováno v: Journal of Surgical Research. 84:77-81

Background, Fas ligand (Fas-L) is thought to provide immune privilege to specific tissues and tumors by inducing an apoptotic signal of cytotoxic T cells expressing its Fas receptor. Purpose. The purpose of this work was to evaluate whether an immort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc02ee3205c08742cb2959a1ef3a146
https://doi.org/10.1006/jsre.1999.5613

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CD44 interacts with EGFR and promotes head and neck squamous cell carcinoma initiation and progression

Autor: Judy Wen, Lutecia Pereira, Kermit L. Carraway, Elizabeth J. Franzmann, David M. Neskey, W. Jarrard Goodwin, Aymee Perez, Erika P. Reategui

Publikováno v: Oral oncology. 49(4)

summary Objectives: CD44 is a promising target for therapy in head and neck squamous cell carcinoma (HNSCC) and has two defined roles in tumorigenesis: it is a cancer stem cell (CSC) marker and it promotes migration and proliferation through interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc3aace55ff9d298d2c664851cc8891
https://pubmed.ncbi.nlm.nih.gov/23265944

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Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma

Autor: Giovana R, Thomas, Judy, Wen

Publikováno v: Anticancer research. 26(6B)

Most tumor tissues, especially those of non-hematopoietic origin, do not express CD80 co-stimulatory molecules, possibly as a mechanism to evade immune surveillance. The objective of this study was to determine whether abundant endogenous CD80 expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07d72b8dcdaa55fac8ca12d6233dd8d6
https://pubmed.ncbi.nlm.nih.gov/17201120

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