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Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia—TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial

Publikováno v: Lancet (London, England)

Summary Background For children with sickle cell anaemia and high transcranial doppler (TCD) flow velocities, regular blood transfusions can effectively prevent primary stroke, but must be continued indefinitely. The efficacy of hydroxycarbamide (hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c7e5d79309566d8761ac8cd85c3945
https://doi.org/10.1016/s0140-6736(15)01041-7

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Transcranial doppler ultrasonography (TCD) in infants with sickle cell anemia: Baseline data from the BABY HUG trial

Autor: Robert J. Adams, Judy Luden, R. Clark Brown, Renee C. Rees, Winfred C. Wang, Zora R. Rogers, Scott T. Miller, Courtney D. Thornburg, Steven G. Pavlakis, Ram Kalpatthi, Xiangke Huang, James F. Casella, Rathi V. Iyer

Publikováno v: Pediatric Blood & Cancer. 54:256-259

Background Transcranial Doppler ultrasonography (TCD) is used to predict stroke risk in children with sickle cell anemia (SCA), but has not been adequately studied in children under age 2 years. Procedure TCD was performed on infants with SCA enrolle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4eec988a2f00b40e104f7a1c67a8b494
https://doi.org/10.1002/pbc.22282

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Stroke Avoidance for Children in REpública Dominicana (SACRED): Protocol for a Prospective Study of Stroke Risk and Hydroxyurea Treatment in Sickle Cell Anemia

Autor: Gabriela S. Urcuyo, Judy Luden, Neelum Jeste, Teresa Latham, Melissa E. Berges, Susan E. Stuber, Rosa M. Nieves, Russell E. Ware, Rafael Mena, Luisanna M Sánchez

Publikováno v: JMIR Research Protocols

Background: In the Dominican Republic, where the burden of sickle cell anemia (SCA) is high, many children lack access to routine screening and preventative care. Children with SCA are at risk for stroke, an event that leads to significant morbidity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85294ce702c9e12224fc41e2904cf11
https://doi.org/10.2196/resprot.7491

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Comparison of transcranial color Doppler imaging (TCDI) and transcranial Doppler (TCD) in children with sickle-cell anemia

Autor: David L. Kinder, Suzanne Saccente, Donald Brambilla, Robert J. Adams, Anne Jones, Elizabeth Carl, Joanna J. Seibert, Fenwick T. Nichols, Katie Cox, Judy Luden

Publikováno v: Pediatric Radiology. 31:461-469

Background. Transcranial Doppler (TCD) has been demonstrated to identify those at highest risk of stroke among children with sickle-cell disease. Based on a randomized clinical trial [Stroke Prevention in Sickle-Cell Anemia Trial (STOP)], which ended

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2c96a3f2040eb3c331753b077a574a
https://doi.org/10.1007/s002470100427

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Variation in Serial TCD Velocity Measurements in the TCD with Transfusions Changing to Hydroxyurea (TWiTCH) Trial

Autor: Judy Luden, Jennifer A. Rothman, Sherron M. Jackson, Russell E. Ware, Margaret T. Lee, Adam Lane, Hamayun Imran, Barry R. Davis, Robert J. Adams, Banu Aygun, Clark Brown, Jennifer Webb, William H. Schultz, Scott T. Miller, Matthew M. Heeney, Alexis A. Thompson, Lori Luchtman-Jones

Publikováno v: Blood. 128:1019-1019

Introduction: The multicenter phase 3 randomized clinical trial TCD With Transfusions Changing to Hydroxyurea (TWiTCH, NCT01425307) investigated whether hydroxyurea could maintain TCD velocities and prevent stroke in children with sickle cell anemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fac8b2af06e856fecd1a9fe0ad667e1
https://doi.org/10.1182/blood.v128.22.1019.1019

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TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia

Publikováno v: Blood. 126:3-3

Transcranial Doppler (TCD) screening in children with sickle cell anemia (SCA) identifies abnormally elevated cerebral artery flow velocities that confer an elevated risk for primary stroke. Chronic transfusions offer effective stroke prophylaxis in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78eaefcb9dad7215762a3ebb41e48b3b
https://doi.org/10.1182/blood.v126.23.3.3

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Transcranial doppler ultrasonography (TCD) in infants with sickle cell anemia: baseline data from the BABY HUG trial

Autor: Steven G, Pavlakis, Renée C, Rees, Xiangke, Huang, R Clark, Brown, James F, Casella, Rathi V, Iyer, Ram, Kalpatthi, Judy, Luden, Scott T, Miller, Zora R, Rogers, Courtney D, Thornburg, Winfred C, Wang, Robert J, Adams

Publikováno v: Pediatric bloodcancer. 54(2)

Transcranial Doppler ultrasonography (TCD) is used to predict stroke risk in children with sickle cell anemia (SCA), but has not been adequately studied in children under age 2 years.TCD was performed on infants with SCA enrolled in the BABY HUG tria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b68c4228e8b9d551f6a8bf67461c00c2
https://pubmed.ncbi.nlm.nih.gov/19927284

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Transcranial Doppler (TCD) Ultrasonography in Infants with Sickle Cell Anemia: Baseline Data from the BABY HUG Trial

Autor: Courtney Thornberg, Ram V. Kalpathi, Zora R. Rogers, R. Clark Brown, Renee C. Rees, Rathi V. Iyer, James F. Casella, Scott T. Miller, Steven G. Pavlakis, Robert J. Adams, Winfred C. Wang, Judy Luden

Publikováno v: Blood. 112:1436-1436

Introduction: Transcranial Doppler ultrasound (TCD) is used in children with sickle cell anemia (SCA) to detect stroke risk. TCD screening is mostly employed in children between 2–16 yrs of age; its use in infants Methods: All subjects underwent a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adb0046da8b255c0164eb2e52a1cf1bb
https://doi.org/10.1182/blood.v112.11.1436.1436

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TCD in Infants: A Report from the BABY HUG Trial

Autor: Robert J. Adams, Russell E. Ware, Judy Luden, Stuart Toledano, Sherri A. Zimmerman, Clark Brown, Duane Bonds, Zora R. Rogers, Renee C. Rees, Scott T. Miller, Caterina P. Minniti, James F. Casella, Li Daner, Sohail Rana, Winfred C. Wang, Rathi V. Iyer, Julio C. Barredo, A. Russell Gerber

Publikováno v: Blood. 106:952-952

Transcranial Doppler (TCD) is useful in children with sickle cell anemia (SCA) to detect increased risk of stroke. The use of TCD in infants less than 2 years of age is less well established, but has previously been shown to be feasible. As a seconda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c024d5565492f072e617f89962d6e1cd
https://doi.org/10.1182/blood.v106.11.952.952

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