Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Judith van Deutekom"'
Autor:
Alper Yavas, Rudie Weij, Maaike van Putten, Eleni Kourkouta, Chantal Beekman, Jukka Puoliväli, Timo Bragge, Toni Ahtoniemi, Jeroen Knijnenburg, Marlies Elisabeth Hoogenboom, Yavuz Ariyurek, Annemieke Aartsma-Rus, Judith van Deutekom, Nicole Datson
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244215 (2020)
Duchenne muscular dystrophy (DMD) is a severe, progressive neuromuscular disorder caused by reading frame disrupting mutations in the DMD gene leading to absence of functional dystrophin. Antisense oligonucleotide (AON)-mediated exon skipping is a th
Externí odkaz:
https://doaj.org/article/77187c115727491f8d71a4bd11be5bd2
Autor:
A Seda Yılmaz-Eliş, Annemieke Aartsma-Rus, Peter AC 't Hoen, Huma Safdar, Cor Breukel, Bart JM van Vlijmen, Judith van Deutekom, Sjef de Kimpe, Gert-Jan van Ommen, J Sjef Verbeek
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
The cytokine interleukin 1(IL-1) initiates a wide range of proinflammatory cascades and its inhibition has been shown to decrease inflammation in a variety of diseases. IL-1 receptor accessory protein (IL-1RAcP) is an indispensible part of the IL-1R
Externí odkaz:
https://doaj.org/article/e2a9f8d60d6d4ae68cee84a3933fcb10
Autor:
Christa L Tanganyika-de Winter, Hans Heemskerk, Tatyana G Karnaoukh, Maaike van Putten, Sjef J de Kimpe, Judith van Deutekom, Annemieke Aartsma-Rus
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Antisense-mediated exon skipping for Duchenne muscular dystrophy (DMD) is currently tested in phase 3 clinical trials. The aim of this approach is to modulate splicing by skipping a specific exon to reframe disrupted dystrophin transcripts, allowing
Externí odkaz:
https://doaj.org/article/179fa3a1a00c43fe8ad29ba4a498c81f
Autor:
Judith van Deutekom, Chantal Beekman, Suzanne Bijl, Sieto Bosgra, Rani van den Eijnde, Dennis Franken, Bas Groenendaal, Bouchra Harquouli, Anneke Janson, Paul Koevoets, Melissa Mulder, Daan Muilwijk, Galyna Peterburgska, Bianca Querido, Janwillem Testerink, Ruurd Verheul, Peter de Visser, Rudie Weij, Annemieke Aartsma-Rus, Jukka Puoliväli, Timo Bragge, Charles O'Neill, Nicole A. Datson
Publikováno v:
Nucleic Acid Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c189efe6f501e93d50dd9a15beb55118
https://doi.org/10.1089/nat.2022.0063
https://doi.org/10.1089/nat.2022.0063
Publikováno v:
Current opinion in molecular therapeutics. 10(2)
Antisense-mediated exon skipping is an approach that uses antisense oligonucleotides (AONs) to modulate splicing by hiding specific sites essential for exon inclusion from the splicing machinery. AONs that block aberrant splice sites can restore norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::deb9f1cec9034fae78c087346ea841d7
https://pubmed.ncbi.nlm.nih.gov/18386226
https://pubmed.ncbi.nlm.nih.gov/18386226