Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Judith Versteegh"'
Autor:
Judith Versteegh, Joeri Johannes Petrus De Wit, Arthur Oubrie, Niels Hoogenboom, Tjeerd Barf, Maaike van Hoek, Bert Kazemier, Allard Kaptein, Carsten Schultz-Fademrecht, Paula Leandro-Garcia, Frank Wijnands, John Dulos, Martin Jaeger, Bas van de Kar, Jeroen A.D.M. de Roos, Gerard Mt Vogel, Mario van Zeeland, Edwin de Zwart, Vera de Kimpe, Judith Borsboom
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(12)
The identification of a potent, selective, and orally available MK2 inhibitor series is described. The initial absence of oral bioavailability was successfully tackled by moving the basic nitrogen of the spiro-4-piperidyl moiety towards the electron-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f22fbd250c5e4013286b26a2ff642b
https://pubmed.ncbi.nlm.nih.gov/21565498
https://pubmed.ncbi.nlm.nih.gov/21565498
Autor:
Judith Versteegh, Nicole Seegers, Henri Klop, Tjeerd Barf, Claudia Hofstra, Jeroen A.D.M. de Roos, Carsten Schultz-Fademrecht, Mario van Zeeland, Arthur Oubrie, Bert Kazemier, Maaike van Hoek, Dennis Demont, Allard Kaptein, Jorrit J. Hornberg, Sander de Wilde, Ruben L. Smeets, Bas van de Kar, Ruud van der Heijden, Richard van Someren
Publikováno v:
Bioorganic & Medicinal Chemistry Letters, 21, 3818-22
Bioorganic & Medicinal Chemistry Letters, 21, 12, pp. 3818-22
Bioorganic & Medicinal Chemistry Letters, 21, 12, pp. 3818-22
Item does not contain fulltext MK2 kinase is a promising drug discovery target for the treatment of inflammatory diseases. Here, we describe the discovery of novel MK2 inhibitors using X-ray crystallography and structure-based drug design. The lead h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdeec28829a3848ff7f20ab076a3584
http://hdl.handle.net/2066/97376
http://hdl.handle.net/2066/97376
