Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Judith Streckfuss"'
Autor:
Kenneth J. Swart, Samuel Barteau, Jennifer Norman, Liezl Gibhard, Lubbe Wiesner, Efrem T. Abay, Philip J. Rosenthal, Jacques Kameni-Tcheudji, Jiri Gut, Matshawandile Tukulula, Mathew Njoroge, Dale Taylor, Kelly Chibale, Judith Streckfuss, Grace Mugumbate
Publikováno v:
ACS medicinal chemistry letters, vol 4, iss 12
A new class of 4-aminoquinolines was synthesized and evaluated in vitro for antiplasmodial activity against both the chloroquine-sensitive (3D7) and -resistant (K1 and W2) strains. The most active compounds 3c-3e had acceptable cytotoxicity but showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018c8e18d0bb7117c3975ce8acda801d
https://doi.org/10.1021/ml400311r
https://doi.org/10.1021/ml400311r
Autor:
Philip J. Rosenthal, Olivier Heudi, Samuel Barteau, Grace Mugumbate, Jacques Kameni-Tcheudji, Jiri Gut, Matshawandile Tukulula, Judith Streckfuss, Kelly Chibale, Mathew Njoroge
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:4904-4913
A series of new deoxyamodiaquine-based compounds was synthesized via the modified TMSN3-Ugi multi-component reaction and evaluated in vitro for antiplasmodial activity. The most potent compounds, 6b, 6c and 6j, showed IC50 values in the range of 6-77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f780bdc80f18d5afe0cb179f2b1f8760
https://doi.org/10.1016/j.bmc.2013.06.067
https://doi.org/10.1016/j.bmc.2013.06.067