Functional Expression and Regulation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels (HCN) in Mouse iPS Cell-derived Cardiomyocytes after UTF1-Neo Selection

Autor: Judith Semmler, Martin Lehmann, Kurt Pfannkuche, Michael Reppel, Jürgen Hescheler, Filomain Nguemo

Publikováno v: Cellular Physiology and Biochemistry, Vol 34, Iss 4, Pp 1199-1215 (2014)

Background/Aims: In vitro reprogramming of somatic cells holds great potential to serve as an autologous source of cells for tissue repair. However, major difficulties in achieving this potential include obtaining homogeneous and stable cells for tra

Externí odkaz: https://doaj.org/article/9fe84a0018494bc199faabb2b1a60fca

Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart

Autor: Annette Köster, Judith Semmler, Filomain Nguemo, Sureshkumar Perumal Srinivasan, Markus Plomann, Daniel Sälzer, Jan Kormann, Michael Reppel, Jürgen Hescheler

Publikováno v: Pharmacological Research. 128:200-210

The Pacsin proteins (Pacsin 1, 2 and 3) play an important role in intracellular trafficking and thereby signal transduction in many cells types. This study was designed to examine the role of Pacsin 2 in cardiac development and function. We investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06d56638769f5ae13428bde1fc54f3e
https://doi.org/10.1016/j.phrs.2017.10.004

Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor

Autor: Andreas Dendorfer, Filomain Nguemo, E. Schleicher, Matthias Matzkies, M. Boehm, Lea Weber, Juergen Hescheler, Judith Semmler, Nikolina Jovancevic, Markus Osterloh, Hanns Hatt, Lian Gelis, Hendrik Milting, J. C. Heckmann, M. Kovarova

Publikováno v: Basic Research in Cardiology

Several studies have demonstrated the expression of odorant receptors (OR) in various human tissues and their involvement in different physiological and pathophysiological processes. However, the functional role of ORs in the human heart is still unc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8e8d7217feb93c05e722b993cea0c6
https://doi.org/10.1007/s00395-017-0600-y

Dynamic Support Culture of Murine Skeletal Muscle-derived Stem Cells Improves Their Cardiogenic Potential In Vitro

Autor: Douglas B. Cowan, Filomain Nguemo, Judith Semmler, Philipp Treskes, Antje-Christin Deppe, Klaus Neef, Yeong-Hoon Choi, Erastus Nembu Nembo, F. Drey, Christof Stamm, Thorsten Wittwer, Guoxing Xu, Thorsten Wahlers, Sureshkumar Perumal Srinivasan, Jürgen Hescheler, Maximilian Scherner, Tomo Saric

Publikováno v: Neef, K, Treskes, P, Xu, G, Drey, F, Perumal Srinivasan, S, Saric, T, Nembo, E, Semmler, J, Nguemo, F, Stamm, C, Cowan, D B, Deppe, A-C, Scherner, M, Wittwer, T, Hescheler, J, Wahlers, T & Choi, Y-H 2015, ' Dynamic Support Culture of Murine Skeletal Muscle-derived Stem Cells Improves Their Cardiogenic Potential In Vitro ', Stem Cells International, vol. 2015, ID 247091 . https://doi.org/10.1155/2015/247091
Stem Cells International, Vol 2015 (2015)
Stem Cells International

Ischemic heart disease is the main cause of death in western countries and its burden is increasing worldwide. It typically involves irreversible degeneration and loss of myocardial tissue leading to poor prognosis and fatal outcome. Autologous cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00445870b785cbef8c297d68c25f8ef8
https://hdl.handle.net/20.500.11820/4b1404a0-310b-40e8-bd1a-819e419c860f

Label-Free Impedance Measurements for Profiling Drug-Induced Cardiotoxicity

Autor: Judith Semmler, Filomain Nguemo, Jürgen Hescheler

Publikováno v: Methods in Pharmacology and Toxicology ISBN: 9781493926169

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccd51cbe00b7cbfbdd505e156b48b37a
https://doi.org/10.1007/978-1-4939-2617-6_16