Lung Marginated and Splenic Murine Resident Neutrophils Constitute Pioneers in Tissue-Defense During Systemic E. coli Challenge

Autor: Goda Juzenaite, Judith Secklehner, Juho Vuononvirta, Yoseph Helbawi, John B. G. Mackey, Charlotte Dean, James A. Harker, Leo M. Carlin, Sara Rankin, Katia De Filippo

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The rapid response of neutrophils throughout the body to a systemic challenge is a critical first step in resolution of bacterial infection such as Escherichia coli (E. coli). Here we delineated the dynamics of this response, revealing novel insights

Externí odkaz: https://doaj.org/article/67efe035c82742a48b93c25118ed42a5

Maturation, developmental site, and pathology dictate murine neutrophil function

Autor: Thomas Jamieson, Ximena L. Raffo-Iraolagoitia, Sergio Lilla, Judith Secklehner, Thomas G. Bird, Daniel J. Murphy, John B. G. Mackey, Colin W. Steele, Gerard J. Graham, Amanda J. McFarlane, William T. Clarke, Leo M. Carlin, Juho Vuononvirta, Rene Jackstadt, Xabier Cortes-Lavaud, Sara Zanivan, Jim C. Norman, Frédéric Fercoq, Owen J. Sansom, Jennifer P. Morton, Katia De Filippo, Ann Hedley, Derek A. Mann, Kathryn Gilroy

Neutrophils have been implicated in poor outcomes in cancer and severe inflammation. We found that neutrophils expressing intermediate levels of Ly6G (Ly6GInt) were present in mouse cancer models and more abundant in those with high rates of spontane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a66015606ee0417065999bdd5a17324e
https://doi.org/10.1101/2021.07.21.453108

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

Autor: Susan M. Mason, John R. P. Knight, Arnaud Echard, Giuseppina Caligiuri, Dide Reijmer, Monika Calka, Flore Kruiswijk, David Sumpton, David Novo, Karen Blyth, Iain R. Macpherson, Karen H. Vousden, Peter Bailey, Sara Zanivan, Kerstin Klinkert, Jim C. Norman, Judith Secklehner, Amanda MacFarlane, Nikki Heath, Huabing Yin, Jennifer P. Morton, Leo M. Carlin, Louise Mitchell, Ewan J. McGhee, Laura Charlton, Emmanuel Dornier

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Nature Communications, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Novo, D, Heath, N, Mitchell, L, Caligiuri, G, MacFarlane, A, Reijmer, D, Charlton, L, Knight, J, Calka, M, McGhee, E, Dornier, E, Sumpton, D, Mason, S, Echard, A, Klinkert, K, Secklehner, J, Kruiswijk, F, Vousden, K, Macpherson, I R, Blyth, K, Bailey, P, Yin, H, Carlin, L M, Morton, J, Zanivan, S & Norman, J C 2018, ' Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ', Nature Communications, vol. 9, no. 1, 5069 . https://doi.org/10.1038/s41467-018-07339-y

Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4508e22176087bbcbdf320820985074e
http://link.springer.com/article/10.1038/s41467-018-07339-y

Intravital microscopy in historic and contemporary immunology

Autor: Cristina Lo Celso, Leo M. Carlin, Judith Secklehner

In this review, we discuss intravital microscopy of immune cells, starting from its historic origins to current applications in diverse organs. It is clear from a quantitative review of the literature that intravital microscopy is a key tool in both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de436ac199e059d4842bc16201ecd6ea
https://europepmc.org/articles/PMC6095455/