Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Judith Schaf"'
Autor:
Judith Schaf, Sonia Shinhmar, Qingyu Zeng, Olivier E. Pardo, Philip Beesley, Nelofer Syed, Robin S. B. Williams
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Glioblastomas are a highly aggressive cancer type which respond poorly to current pharmaceutical treatments, thus novel therapeutic approaches need to be investigated. One such approach involves the use of the bioactive natural product Tansh
Externí odkaz:
https://doaj.org/article/eb1ae5def32c41aba2ef94e86feb2080
Autor:
Robin Williams, Judith Schaf, Sonia Shinhmar, Qingyu Zeng, Olivier Pardo, Philip Beesley, Nelofer Syed
Publikováno v:
Cell Death Discovery. 9
Glioblastomas are a highly aggressive cancer type which respond poorly to current pharmaceutical treatments, thus novel therapeutic approaches need to be investigated. One such approach involves the use of the bioactive natural product tanshinone IIA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fef59dba4edbd01b637ce877973728
https://doi.org/10.1038/s41420-023-01462-6
https://doi.org/10.1038/s41420-023-01462-6
Autor:
Anne Drougard, Eric H Ma, Vanessa Wegert, Ryan Sheldon, Ilaria Panzeri, Naman Vatsa, Stefanos Apostle, Luca Fagnocchi, Judith Schaf, Klaus Gossens, Josephine Völker, Shengru Pang, Anna Bremser, Erez Dror, Francesca Giacona, null Sagar, Michael X Henderson, Marco Prinz, Russell G Jones, J. Andrew Pospisilik
Chronic high-fat feeding triggers widespread metabolic dysfunction including obesity, insulin resistance, and diabetes. While these ultimate pathological states are relatively well understood, we have a limited understanding of how high-fat intake fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f396eac4320c577d48d58931e1d889c2
https://doi.org/10.1101/2023.04.03.535373
https://doi.org/10.1101/2023.04.03.535373
Publikováno v:
Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 33, Iss , Pp 43-48 (2024)
Background: Reference measurement procedures are an essential element in the standardization and comparability of analytical measurement results in laboratory medicine. No LC-MS/MS-based reference measurement procedure for cefepime in serum has been
Externí odkaz:
https://doaj.org/article/c7988184361e47b2ac956f78fa3a8538
Autor:
Eleanor C. Warren, Joseph Damstra-Oddy, Lisa Costelloe, John-Mark K. Fitzpatrick, Yann Desfougères, Christopher J. Perry, Robin S.B. Williams, Adolfo Saiardi, Judith Schaf, Eric J. Downer, William H Hind
Publikováno v:
British Journal of Pharmacology. 178:1149-1163
Background and purpose Cannabidiol (CBD) has been shown to differentially regulate the mechanistic target of rapamycin complex 1 (mTORC1) in preclinical models of disease, where it reduces activity in models of epilepsies and cancer and increases it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d778dc0e9a75c13f1974403071e6d1f
https://doi.org/10.1111/bph.15351
https://doi.org/10.1111/bph.15351
Autor:
Robin S.B. Williams, Eleonora Lugarà, Joseph Damstra-Oddy, Eleanor C. Warren, Vivi M. Heine, Judith Schaf, Stephanie Dooves, Matthew C. Walker
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 117(38), 23617-23625. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(38), 23617-23625. National Academy of Sciences
Warren, E C, Dooves, S, Lugarà, E, Damstra-Oddy, J, Schaf, J, Heine, V M, Walker, M C & Williams, R S B 2020, ' Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 38, pp. 23617-23625 . https://doi.org/10.1073/pnas.2008980117
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117(38), 23617-23625. National Academy of Sciences
Warren, E C, Dooves, S, Lugarà, E, Damstra-Oddy, J, Schaf, J, Heine, V M, Walker, M C & Williams, R S B 2020, ' Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 38, pp. 23617-23625 . https://doi.org/10.1073/pnas.2008980117
Proceedings of the National Academy of Sciences of the United States of America
Significance The mTORC1 complex provides a critical role in cell function, regulating a variety of processes including growth and autophagy. mTORC1 signaling is hyperactivated in a range of common diseases including cancer, epilepsy, and neurodegener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19e3ae2d3ba9f9265e903dc3f80f665
https://research.vu.nl/en/publications/d95d1234-573b-4308-8a86-e833e7ba0ea7
https://research.vu.nl/en/publications/d95d1234-573b-4308-8a86-e833e7ba0ea7
Publikováno v:
The International journal of developmental biology. 63(8-9-10)
Developing novel compounds for the treatment of diseases remains one of the highest priorities in biomedical research, where it is critical to identify their targets and how they work at a cellular level. Most studies in this area employ mammalian mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5ef99ab98a9d0bddc2bab0fad86780
https://pubmed.ncbi.nlm.nih.gov/31840791
https://pubmed.ncbi.nlm.nih.gov/31840791
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/d6644edc5dfa4912b226a39d79341788
Publikováno v:
BMC Psychiatry, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background After stressful event exposure, higher perceived social support is a well-established correlate of decreased risk for psychological symptoms, including depressive, anxiety and posttraumatic stress (PTS) symptoms. However, longitud
Externí odkaz:
https://doaj.org/article/dc59b036d863499b838537dc9be1b67e
Publikováno v:
BMC Psychology, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract Background and objectives Disorder-specific forms of Repetitive Negative Thinking (RNT) are associated with multiple diagnostic categories, indicating a transdiagnostic nature. Few studies examined content-independent RNT processes across gr
Externí odkaz:
https://doaj.org/article/35287e487c83429bb1cb2a9e4d0b7c08