Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Judith Romero-Gallo"'
Autor:
Jennifer M. Noto, M. Blanca Piazuelo, Judith Romero-Gallo, Alberto G. Delgado, Giovanni Suarez, Konstantina Akritidou, Miguel Girod Hoffman, Juan Carlos Roa, Cormac T. Taylor, Richard M. Peek
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTHelicobacter pylori-induced inflammation is the strongest known risk factor for gastric adenocarcinoma. Hypoxia-inducible factor-1 (HIF-1α) is a key transcriptional regulator of immunity and carcinogenesis. To examine the role of this mediat
Externí odkaz:
https://doaj.org/article/5ca1554c76e54c8382886b3806ff21b3
Autor:
Samuel D.R. Dooyema, Jennifer M. Noto, Lydia E. Wroblewski, M. Blanca Piazuelo, Uma Krishna, Giovanni Suarez, Judith Romero-Gallo, Alberto G. Delgado, Richard M. Peek
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Chronic mucosal pathogens have evolved multiple strategies to manipulate the host immune response; consequently, microbes contribute to the development of >2 million cases of cancer/year. Gastric adenocarcinoma is the fourth leading cause of cancer-r
Externí odkaz:
https://doaj.org/article/f93259ca2dbb4a9897baa17e0061a47a
Autor:
Jennifer M. Noto, M. Blanca Piazuelo, Shailja C. Shah, Judith Romero-Gallo, Jessica L. Hart, Chao Di, James D. Carmichael, Alberto G. Delgado, Alese E. Halvorson, Robert A. Greevy, Lydia E. Wroblewski, Ayushi Sharma, Annabelle B. Newton, Margaret M. Allaman, Keith T. Wilson, M. Kay Washington, M. Wade Calcutt, Kevin L. Schey, Bethany P. Cummings, Charles R. Flynn, Joseph P. Zackular, Richard M. Peek Jr.
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host, and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in INS-GAS mice under iron-deficient conditions. Mechanistically, thes
Externí odkaz:
https://doaj.org/article/7d198f5f9fa7400583ab84388b9c0680
Autor:
Andrés Julián Gutiérrez-Escobar, Billie Velapatiño, Victor Borda, Charles S. Rabkin, Eduardo Tarazona-Santos, Lilia Cabrera, Jaime Cok, Catherine C. Hooper, Helena Jahuira-Arias, Phabiola Herrera, Mehwish Noureen, Difei Wang, Judith Romero-Gallo, Bao Tran, Richard M. Peek, Douglas E. Berg, Robert H. Gilman, M. Constanza Camargo
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Region-specific Helicobacter pylori subpopulations have been identified. It is proposed that the hspAmerind subpopulation is being displaced from the Americans by an hpEurope population following the conquest. Our study aimed to describe the genomes
Externí odkaz:
https://doaj.org/article/b6b76ee877c3446495f39bc0a0397410
Autor:
Jennifer M. Noto, Joseph P. Zackular, Matthew G. Varga, Alberto Delgado, Judith Romero-Gallo, Matthew B. Scholz, M. Blanca Piazuelo, Eric P. Skaar, Richard M. Peek
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma; however, most infected individuals never develop this malignancy. Strain-specific microbial factors, such as the oncoprotein CagA, as well as environmental conditio
Externí odkaz:
https://doaj.org/article/4e1d7e064e0343d7a2ef53ea353bd1c7
Autor:
Aeryun Kim, Stephanie L Servetas, Jieun Kang, Jinmoon Kim, Sungil Jang, Ho Jin Cha, Wan Jin Lee, June Kim, Judith Romero-Gallo, Richard M Peek, D Scott Merrell, Jeong-Heon Cha
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176468 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0137078.].
Externí odkaz:
https://doaj.org/article/bbac3851c0064d968e4c8d85d6034042
Autor:
Ge Wang, Judith Romero-Gallo, Stéphane L. Benoit, M. Blanca Piazuelo, Ricardo L. Dominguez, Douglas R. Morgan, Richard M. Peek, Robert J. Maier
Publikováno v:
mBio, Vol 7, Iss 4 (2016)
ABSTRACT A known virulence factor of Helicobacter pylori that augments gastric cancer risk is the CagA cytotoxin. A carcinogenic derivative strain, 7.13, that has a greater ability to translocate CagA exhibits much higher hydrogenase activity than it
Externí odkaz:
https://doaj.org/article/0bd3243815314c17a2bcffe12026516b
Autor:
Aeryun Kim, Stephanie L Servetas, Jieun Kang, Jinmoon Kim, Sungil Jang, Ho Jin Cha, Wan Jin Lee, June Kim, Judith Romero-Gallo, Richard M Peek, D Scott Merrell, Jeong-Heon Cha
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0137078 (2015)
Helicobacter pylori genetic variation is a crucial component of colonization and persistence within the inhospitable niche of the gastric mucosa. As such, numerous H. pylori genes have been shown to vary in terms of presence and genomic location with
Externí odkaz:
https://doaj.org/article/593106271502474d9a609816c41d088a
Autor:
Jennifer M Noto, Tinatin Khizanishvili, Rupesh Chaturvedi, M Blanca Piazuelo, Judith Romero-Gallo, Alberto G Delgado, Shradha S Khurana, Johanna C Sierra, Uma S Krishna, Giovanni Suarez, Anne E Powell, James R Goldenring, Robert J Coffey, Vincent W Yang, Pelayo Correa, Jason C Mills, Keith T Wilson, Richard M Peek
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54344 (2013)
Helicobacter pylori is the strongest known risk factor for the development of gastric adenocarcinoma. H. pylori expresses a repertoire of virulence factors that increase gastric cancer risk, including the cag pathogenicity island and the vacuolating
Externí odkaz:
https://doaj.org/article/1cc0b00deeb940f8b0d725b0b82385e7
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002050 (2011)
Helicobacter pylori (Hp) injects the CagA effector protein into host epithelial cells and induces growth factor-like signaling, perturbs cell-cell junctions, and alters host cell polarity. This enables Hp to grow as microcolonies adhered to the host
Externí odkaz:
https://doaj.org/article/9740d0bf8abe4fc5934f9dcf268add59