Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Judith Nuber"'
Autor:
Martina P. Liebl, Sarah C. Meister, Lisa Frey, Kristina Hendrich, Anja Klemmer, Bettina Wohlfart, Christopher Untucht, Judith Nuber, Christian Pohl, Viktor Lakics
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Autophagic flux can be quantified based on the accumulation of lipidated LC3B in the presence of late-stage autophagy inhibitors. This method has been widely applied to identify novel compounds that activate autophagy. Here we scrutinize thi
Externí odkaz:
https://doaj.org/article/7dbbdffe84b44629831348a9282b7db8
Autor:
Martina P. Morawe, Fan Liao, Willi Amberg, Jeroen van Bergeijk, Rui Chang, Mary Gulino, Caitlin Hamilton, Carolin Hoft, Casey Lumpkin, Bryan Mastis, Emily McGlame, Judith Nuber, Christian Plaas, Brinda Ravikumar, Kaushambi Roy, Marion Schanzenbächer, Joseph Tierno, Viktor Lakics, Tammy Dellovade, Matthew Townsend
Publikováno v:
European Journal of Pharmacology. 934:175301
In this study we aimed to reduce tau pathology, a hallmark of Alzheimer's Disease (AD), by activating mTOR-dependent autophagy in a transgenic mouse model of tauopathy by long-term dosing of animals with mTOR-inhibitors. Rapamycin treatment reduced t
Autor:
Martina P. Liebl, Sarah C. Meister, Lisa Frey, Kristina Hendrich, Anja Klemmer, Bettina Wohlfart, Christopher Untucht, Judith Nuber, Christian Pohl, Viktor Lakics
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Autophagic flux can be quantified based on the accumulation of lipidated LC3B in the presence of late-stage autophagy inhibitors. This method has been widely applied to identify novel compounds that activate autophagy. Here we scrutinize this approac