Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Judith N. Mandl"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Lymphoid organs are unusual multicellular tissues: they are densely packed, but the lymphocytes trafficking through them are actively moving. We hypothesize that the intriguing ability of lymphocytes to avoid jamming and clogging is in part
Externí odkaz:
https://doaj.org/article/1d0e15b1026d44288572175d1404e14b
Publikováno v:
Cells, Vol 9, Iss 3, p 690 (2020)
Our immune system can destroy most cells in our body, an ability that needs to be tightly controlled. To prevent autoimmunity, the thymic medulla exposes developing T cells to normal “self” peptides and prevents any responders from entering the b
Externí odkaz:
https://doaj.org/article/08a9170f8f104805b9e61fcb2e07e1b1
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
A majority of viruses that have caused recent epidemics with high lethality rates in people, are zoonoses originating from wildlife. Among them are filoviruses (e.g., Marburg, Ebola), coronaviruses (e.g., SARS, MERS), henipaviruses (e.g., Hendra, Nip
Externí odkaz:
https://doaj.org/article/5581d7d7b1dc409abc548cb371526b9c
Autor:
Connie Shen, Eva Mulder, Wiebe Buitenwerf, Jérémy Postat, Aron Jansen, Matthijs Kox, Judith N. Mandl, Nienke Vrisekoop
Publikováno v:
Journal of Cell Science, 136, 11
Journal of Cell Science, 136
Journal of Cell Science, 136
Contains fulltext : 293544.pdf (Publisher’s version ) (Open Access) Neutrophils are among the fastest-moving immune cells. Their speed is critical to their function as 'first responder' cells at sites of damage or infection, and it has been postula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f1361636e552f29a17a141073b2acd
https://doi.org/10.1242/jcs.260768
https://doi.org/10.1242/jcs.260768
Autor:
Sheri A.C. McDowell, Simon Milette, Samuel Doré, Miranda W. Yu, Mark Sorin, Liam Wilson, Lysanne Desharnais, Alyssa Cristea, Ozgun Varol, Aline Atallah, Anikka Swaby, Valérie Breton, Azadeh Arabzadeh, Sarah Petrecca, Hamza Loucif, Aanya Bhagrath, Meghan De Meo, Katherine D. Lach, Marianne S.M. Issac, Benoit Fiset, Roni F. Rayes, Judith N. Mandl, Jörg H. Fritz, Pierre O. Fiset, Peter R. Holt, Andrew J. Dannenberg, Jonathan D. Spicer, Logan A. Walsh, Daniela F. Quail
Publikováno v:
Journal of Experimental Medicine. 220
Obesity is characterized by chronic systemic inflammation and enhances cancer metastasis and mortality. Obesity promotes breast cancer metastasis to lung in a neutrophil-dependent manner; however, the upstream regulatory mechanisms of this process re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0513b49a5eb34570c41164f108f0db
https://doi.org/10.1084/jem.20220509
https://doi.org/10.1084/jem.20220509
Autor:
Judith N. Mandl, Heather J. Melichar
Publikováno v:
Cellular & Molecular Immunology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d036384a009e5bf00496501842454e43
https://doi.org/10.1038/s41423-023-01021-0
https://doi.org/10.1038/s41423-023-01021-0
We recently conducted an exploratory analysis of murine T cell receptor (TCR) repertoire data (biorxiv doi:10.1101/2022.11.23.517563).Specifically, we analyzed the complement-determining region 3 (CDR3) of the TCRβ chain from naïve CD4+T cell popul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df714bf24b53357b493c459d77e2d32
Autor:
Johannes Textor, Franka Buytenhuijs, Dakota Rogers, Ève Mallet Gauthier, Shabaz Sultan, Inge M. N. Wortel, Kathrin Kalies, Anke Fähnrich, René Pagel, Heather J. Melichar, Jürgen Westermann, Judith N. Mandl
SummaryThe T cell receptor (TCR) determines the specificity and affinity for both foreign and self-peptides presented by MHC. It is established that self-pMHC reactivity impacts T cell function, but it has been challenging to identify TCR sequence fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edc9027d2582ce5a6cf550c31dc65956
https://doi.org/10.1101/2022.11.23.517563
https://doi.org/10.1101/2022.11.23.517563
Publikováno v:
Seminars in immunology. 65
There is a long-standing assumption that naive CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5da14a963ba7b106baeffeaee42b40
https://pubmed.ncbi.nlm.nih.gov/36463711
https://pubmed.ncbi.nlm.nih.gov/36463711
SummaryThe pathogens to which T cells respond is determined by the T cell receptors (TCRs) present in an individual’s repertoire. Although more than 90% of the TCR repertoire is generated by terminal deoxynucleotidyl transferase (TdT)-mediated N-nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c73f0aa1eb5d61bcefef82704eda466a
https://doi.org/10.1101/2022.06.26.497644
https://doi.org/10.1101/2022.06.26.497644