Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Judith Marfurt"'
Autor:
Nathalie Favre, Ramanathan Saiganesh, Harihara Subramanian Meera, Linli He, Gail Underiner, Stephen R. Tudhope, Julie A. Bellamy, Judith Marfurt, Dewakar Rajasekar, Jesudoss Mercy Gnanadeepam, Frank Gibson, Carl Henry Behrens, Manouchehr Azadi-Ardakani, Anthony Ball
Publikováno v:
Organic Process Research & Development. 16:635-642
A safe, practical and scalable process for manufacture of (−)-huperzine A has been developed and scaled up to manufacture several hundred grams of (−)-huperzine A with chemical and optical purity of >99%. The process consists of 11 chemical stage
Autor:
Austin McMordie, William Watters, Sean L. Kitson, Loïc Leman, Jana Cairns, Rodney T. Brown, Judith Marfurt, Victor L. Murrell
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 54:720-730
A method has been developed for the synthesis of two isotopically labelled forms of a pro-drug of the acetylcholinesterase inhibitor (� )-huperzine A. These labelled compounds, [ 14 C]ZT-1 (Debio-9902) and [d3]ZT-1, were used in clinical studies to
Autor:
Judith Marfurt, Florence Philippoz, Frédéric Lallemand, Philippe Perottet, Werner Kloeti, Kamel Besseghir, Olivia Felt-Baeyens, Robert Gurny
Publikováno v:
European Journal of Pharmaceutical Sciences, Vol. 26, No 1 (2005) pp. 124-129
UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) developed for topical eye delivery. Such a prodrug has to fulfil two paradoxical requirements as it must be rapidly hydrolysed under physiological conditions but also retain a long shelf-life
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:411-417
A systematic investigation of a series of triplex forming oligonucleotides (TFOs) containing alpha-, and beta-thymidine, alpha- and beta-N7-hypoxanthine, and alpha- and beta-N7 and N9 aminopurine nucleosides, designed to bind to T-A inversion sites i
Autor:
Judith Marfurt, Christian J. Leumann
Publikováno v:
Angewandte Chemie. 110:184-187
Die effiziente Erkennung der Pyrimidinbase Uracil durch Hypoxanthin oder Thymin im parallelen DNA-Triplexmotiv erfolgt uber eine konventionelle N−H⋅⋅⋅O- und eine nichtkonventionelle C−H⋅⋅⋅O-Wasserstoffbrucke (siehe rechts).
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:3021-3024
The α-nucleoside 7-(2′-deoxy-α-D-ribofuranosyl)hypoxanthine, incorporated into an otherwise β-configured oligodeoxynucleotide that is designed to bind to a DNA duplex in the parallel motif, recognizes selectively and efficiently a G-C base pair,
Autor:
R. Judd, M. Hazenkamp, Jürg Hauser, Judith Marfurt, Huldreich Trafelet, Christian J. Leumann, A. Zingg, M. Förtsch, Thomas R. Ward, Hans-Beat Bürgi, Eugen Stulz, S. Schenker, G. Strouse
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 52:713-716
Publikováno v:
Helvetica Chimica Acta. 77:351-371
The synthesis of four electropolymerizable 2,2′-bipyridinium salts with tuned reduction potential (E1∘) is described (N,N′-ethylene-4-methyl-4′-vinyl-2,2′-bipyridinium dibromide (4; E1∘ –0.48 V), 4-methyl-N, N′-(trimethylene)-4′-vin
Autor:
Valerie Nicolas-Metral, Laura Novaroli, Jean-Maurice Dumont, Raf Crabbé, Judith Marfurt, Grégoire Vuagniaux
Publikováno v:
Expert opinion on investigational drugs. 18(2)
Debio 025 is a cyclophilin (Cyp) inhibitor without calcineurin-binding properties. The drug inhibits viral replication of genotype 1b and 2a replicons in nanomolar concentrations and shows an additive to synergistic antiviral effect with interferon,
Autor:
Kiyohiko Nakai, Anne Vaslin, Jeffrey G. Supko, Claudio Zanna, Andreas Layer, Valerie Nicolas-Metral, Jerome Douchain, Nobuya Ishii, Daniela Purcea, Marie-Claude Roubaudi-Fraschini, Sebastien Chabaud, Annick Menetrey, Judith Marfurt
Publikováno v:
Cancer Research. 75:CT228-CT228
Background: Deregulated fibroblast growth factor receptor (FGFR) signaling is associated with tumorigenesis. The oral selective FGFR 1, 2, 3 inhibitor Debio 1347, a Biopharmaceutical Classification System Class II drug, is currently investigated in a