Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Judith M. LaLonde"'
Autor:
Young Do Kwon, Judith M LaLonde, Yongping Yang, Mark A Elban, Akihiro Sugawara, Joel R Courter, David M Jones, Amos B Smith, Asim K Debnath, Peter D Kwong
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85940 (2014)
Efforts to develop therapeutic agents that inhibit HIV-1 entry have led to the identification of several small molecule leads. One of the most promising is the NBD series, which binds within a conserved gp120 cavity and possesses para-halogen substit
Externí odkaz:
https://doaj.org/article/e73d4da82ce24696811bc79c63f7a780
Autor:
Amos B. Smith, Jongwoo Park, Amy M. Princiotto, Hua-Xin Liao, Joel R. Courter, Sallie R. Permar, James E. Robinson, Judith M. LaLonde, Joseph Sodroski, Navid Madani, Ernesto Freire, Yu Feng, David M. Jones, Anthony Moody, Richard T. Wyatt, Arne Schön, Barton F. Haynes
Publikováno v:
Journal of Virology. 88:6542-6555
Approaches to prevent human immunodeficiency virus (HIV-1) transmission are urgently needed. Difficulties in eliciting antibodies that bind conserved epitopes exposed on the unliganded conformation of the HIV-1 envelope glycoprotein (Env) trimer repr
Autor:
Joseph Sodroski, Wayne A. Hendrickson, Amos B. Smith, Ernesto Freire, Joel R. Courter, Irwin Chaiken, Peter D. Kwong, Judith M. LaLonde, Navid Madani, Arne Schön
Publikováno v:
Accounts of Chemical Research
Conspectus This Account provides an overview of a multidisciplinary consortium focused on structure-based strategies to devise small molecule antagonists of HIV-1 entry into human T-cells, which if successful would hold considerable promise for the d
Publikováno v:
International Journal of Tryptophan Research, Vol 2013, Iss 6, Pp 35-45 (2013)
Autor:
Carole A. Bewley, Cameron F. Abrams, Judith M. LaLonde, Ferit Tuzer, Diogo Rodrigo Magalhães Moreira, Ali Emileh, Irwin Chaiken, Herman Yeh, M. Umashankara
Publikováno v:
Biochemistry. 52:2245-2261
Peptide triazole (PT) entry inhibitors prevent HIV-1 infection by blocking the binding of viral gp120 to both the HIV-1 receptor and the coreceptor on target cells. Here, we used all-atom explicit solvent molecular dynamics (MD) to propose a model fo
Autor:
Elizabeth C. Upton, Karyn McFadden, Navid Madani, Andrew P. Holmes, Isaac Zentner, Ferit Tuzer, Srivats Rajagopal, Kantharaju Kamanna, Judith M. LaLonde, Joseph Sodroski, Mark Contarino, Irwin Chaiken
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 81:271-290
Despite advances in HIV therapy, viral resistance and side-effects with current drug regimens require targeting new components of the virus. Dual antagonist peptide triazoles (PT) are a novel class of HIV-1 inhibitors that specifically target the gp1
Autor:
Bruno Melillo, Michael S. Seaman, Joel R. Courter, Wayne A. Hendrickson, Judith M. LaLonde, Amos B. Smith, Joseph Sodroski, Jongwoo Park, Ernesto Freire, Arne Schön, Shuaiyi Liang, Amy M. Princiotto, Daniel J. Wendler, Navid Madani
Publikováno v:
ACS medicinal chemistry letters. 7(3)
The optimization, based on computational, thermodynamic, and crystallographic data, of a series of small-molecule ligands of the Phe43 cavity of the envelope glycoprotein gp120 of human immunodeficiency virus (HIV) has been achieved. Importantly, bio
Autor:
Jeremy R. Greenwood, George J. Leslie, Mark K. Louder, Carole A. Bewley, Leah L. Frye, Timothy S. Luongo, Cajetan Dogo-Isonagie, Priyamvada Acharya, Loïc Martin, Son N. Lam, K. Shawn Watts, Asim K. Debnath, Peter D. Kwong, John R. Mascola, Judith M. LaLonde, James A. Hoxie
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 2011, 6 (10), pp.1069-1077. ⟨10.1021/cb200068b⟩
ACS Chemical Biology, American Chemical Society, 2011, 6 (10), pp.1069-1077. ⟨10.1021/cb200068b⟩
ACS Chemical Biology, 2011, 6 (10), pp.1069-1077. ⟨10.1021/cb200068b⟩
ACS Chemical Biology, American Chemical Society, 2011, 6 (10), pp.1069-1077. ⟨10.1021/cb200068b⟩
Tyrosine sulfate-mediated interactions play an important role in HIV-1 entry. After engaging the CD4 receptor at the cell surface, the HIV-1 gp120 glycoprotein binds to the CCR5 co-receptor via an interaction that requires two tyrosine sulfates, at p
Publikováno v:
Chemical Biology & Drug Design. 77:161-165
The binding affinity is determined by the Gibbs energy of binding (ΔG) which is the sum of enthalpic (ΔH) and entropic (-TΔS) contributions. Because the enthalpy and entropy contribute in an additive way to the binding energy, the same binding aff
Autor:
Joseph Sodroski, Amos B. Smith, Akihiro Sugawara, Takahiro Soeta, Joel R. Courter, Amy M. Princiotto, Mark A. Elban, Judith M. LaLonde, Ernesto Freire, Navid Madani, Young Do Kwon, Peter D. Kwong, Arne Schön
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:91-101
The low-molecular-weight compound JRC-II-191 inhibits infection of HIV-1 by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor and is therefore an important lead in the development of a potent viral entry inhibitor. Rep