Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Judith M. Hills"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:515-518
The GABAB receptor affinity of a number of GABA analogues, where the carboxylic acid group has been replaced with a range of acidic moieties, were determined. The phosphinic acid analogue (1) was identified as a potent selective GABAB ligand which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4283daae0a932b41bb3104b4c8c9406
https://doi.org/10.1016/s0960-894x(01)81218-x
https://doi.org/10.1016/s0960-894x(01)81218-x
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::113a40e5d393d915bf170a0316ae8e2a
https://doi.org/10.1002/chin.199215232
https://doi.org/10.1002/chin.199215232
Autor:
Judith M. Hills, Philip I. Aaronson
Publikováno v:
Gastroenterology. 101:55-65
An investigation of the mechanism of peppermint oil action was performed using isolated pharmacological preparations from guinea pig large intestine and patch clamp electrophysiology techniques on rabbit jejunum. Peppermint oil relaxed carbachol-cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ecee548d0f8c8aa1b95a37147f82bd1
https://doi.org/10.1016/0016-5085(91)90459-x
https://doi.org/10.1016/0016-5085(91)90459-x
Autor:
Kenneth B. Mackay, Frank C. Barone, Barry Sidney Orlek, Judith M. Hills, V.Ann Lewis, Andrew A. Parsons, Christopher D. Benham, Sarah J. Hadingham, A. Jacqueline Hunter, Colin A. Campbell, Raymond F. White, Mark H Harries, John David Harling
Publikováno v:
European journal of pharmacology. 401(3)
For progression to clinical trials in stroke, putative neuroprotective compounds should show robust efficacy post-ischaemia in several experimental models of stroke. This paper describes the characterisation of (+)(1S, 2R)-cis-1-[4-(1-methyl-1-phenyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfeb2b76498694e157429c6a2920bb4
https://pubmed.ncbi.nlm.nih.gov/10936502
https://pubmed.ncbi.nlm.nih.gov/10936502
Publikováno v:
British journal of pharmacology. 102(3)
1. A series of GABAB receptor antagonists were tested against (+/-)-baclofen for activity on the presynaptic GABAB receptor in the rat vas deferens. 2. All the antagonists tested caused a rightward shift in the concentration-response curve to (+/-)-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be738c42b02c13a4918fbca0fa955fd7
https://pubmed.ncbi.nlm.nih.gov/1364830
https://pubmed.ncbi.nlm.nih.gov/1364830
Publikováno v:
British journal of pharmacology. 102(1)
CGP 35348 (3-aminopropyl(diethoxymethyl)phosphinic acid) and 3-aminopropyl(n-hexyl)phosphinic acid (3-APHPA) were tested in the rat anococcygeus muscle against CGP 27492 (3-aminopropylphosphinic acid), a selective GABAB agonist, for their antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4491128b3a86f886cdb63f135c952837
https://pubmed.ncbi.nlm.nih.gov/1646062
https://pubmed.ncbi.nlm.nih.gov/1646062
Publikováno v:
British Journal of Pharmacology. 81:533-541
The effects of 5'-N-ethylcarboxamidoadenosine (NECA), L-NECA, 2-chloroadenosine, N6-phenylisopropyladenosine (L-PIA and D-PIA), cyclohexyladenosine (CHA), and adenosine were examined on the guinea-pig taenia coli. All the analogues except L-NECA caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0b3bfb5cf0265cd05b103fb762a975
https://doi.org/10.1111/j.1476-5381.1984.tb10106.x
https://doi.org/10.1111/j.1476-5381.1984.tb10106.x
Publikováno v:
European Journal of Pharmacology. 99:287-293
Electrical field stimulation of the isolated pig bladder neck preparation initiated rapid non-adrenergic, non-cholinergic nerve-mediated relaxations. A wide range of substances were examined as possible candidates for the neurotransmitter involved. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38126bc47eae8a056f4b383a16898aa8
https://doi.org/10.1016/0014-2999(84)90135-3
https://doi.org/10.1016/0014-2999(84)90135-3
Publikováno v:
European journal of pharmacology. 88(4)
The effect of vasoactive intestinal polypeptide (VIP) on the electrical activity of the smooth muscle of the guinea-pig taenia coli has been examined using the single sucrose gap apparatus. VIP usually caused a slowly developing, long-lasting membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a91fa51ddb507f0754ff04a11578ef
https://pubmed.ncbi.nlm.nih.gov/6305677
https://pubmed.ncbi.nlm.nih.gov/6305677
Publikováno v:
Synapse (New York, N.Y.). 2(4)
Responses to substance P (SP) and to hypogastric nerve stimulation were recorded from voltage-clamped guinea pig inferior mesenteric ganglion (IMG) neurons, and compared with those to muscarine. Muscarine produced a voltage-dependent inward current a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a734b9db930b6f7a92d652a49687c6b5
https://pubmed.ncbi.nlm.nih.gov/2460961
https://pubmed.ncbi.nlm.nih.gov/2460961