Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Judith M. Healy"'
Autor:
Thomas V. Holohan, Christopher J. Horvath, Tia DeFeo-Fraulini, H. Nicholas Marsh, Robert G. Schaub, Sleiman BouFakhreddine, James C. Gilbert, Judith M. Healy, Renta Hutabarat, Patricia G. Merlino
Publikováno v:
Circulation. 116:2678-2686
Background— ARC1779 is a therapeutic aptamer antagonist of the A1 domain of von Willebrand Factor (vWF), the ligand for receptor glycoprotein 1b on platelets. ARC1779 is being developed as a novel antithrombotic agent for use in patients with acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c290da4be7e22fd6f1cdee69273417
https://doi.org/10.1161/circulationaha.107.724864
https://doi.org/10.1161/circulationaha.107.724864
Autor:
Markus Kurz, Charles Wilson, Scott D. Lewis, Kristin Thompson, Judith M. Healy, Thomas Green Mccauley, Ryan M. Boomer
Publikováno v:
Pharmaceutical Research. 21:2234-2246
Aptamers are highly selective nucleic acid-based drugs that are currently being developed for numerous therapeutic indications. Here, we determine plasma pharmacokinetics and tissue distribution in rat of several novel aptamer compositions, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285755f5b29454ab803a34287b1bb985
https://doi.org/10.1007/s11095-004-7676-4
https://doi.org/10.1007/s11095-004-7676-4
Publikováno v:
Protein & Peptide Letters. 5:185-191
Abstract: The M. tuberculosis rpoA gene, encoding the a subunit of RNA polymerase, was isolated by a polymerase chain reaction-based strategy using primers directed against regions of a that are highly conserved among Gram-positive and Gram-negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90498a31e26c23ca1b10d19eb7b4d3f9
https://doi.org/10.2174/092986650504221111114054
https://doi.org/10.2174/092986650504221111114054
Publikováno v:
Protein & Peptide Letters. 3:23-30
Abstract: We have selected RGD peptides recognized efficiently by integrin av3 through randomization of amino acids flanking the RGD motif. Degenerate RGD peptides were displayed on phage as fusions to the N-terminus of major coat protein Vill of M13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::194ba6c983670b2baed2a8cfa0a917cd
https://doi.org/10.2174/092986650301220608153153
https://doi.org/10.2174/092986650301220608153153
Publikováno v:
ChemInform. 39
Aptamers are non-naturally occurring structured oligonucleotides that may bind to small molecules, peptides, and proteins. Typically, aptamers are generated by an in vitro selection process referred to as SELEX (systematic evolution of ligands by exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f038001516590495ebc34c7da3369514
https://doi.org/10.1002/chin.200818243
https://doi.org/10.1002/chin.200818243
Publikováno v:
Accounts of chemical research. 41(1)
Aptamers are non-naturally occurring structured oligonucleotides that may bind to small molecules, peptides, and proteins. Typically, aptamers are generated by an in vitro selection process referred to as SELEX (systematic evolution of ligands by exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e293282f1d4cd347ff62372dd33fe46b
https://pubmed.ncbi.nlm.nih.gov/18193823
https://pubmed.ncbi.nlm.nih.gov/18193823
Publikováno v:
The Aptamer Handbook: Functional Oligonucleotides and Their Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e23e7c0974876e18807e9d327563a51c
https://doi.org/10.1002/3527608192.ch17
https://doi.org/10.1002/3527608192.ch17
Publikováno v:
Journal of biomolecular techniques : JBT. 16(3)
In the simplest view, aptamers can be thought of as nucleic acid analogs to antibodies. They are able to bind specifically to proteins, and, in many cases, that binding leads to a modulation of protein activity. New aptamers are rapidly generated thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3b83216f973be2fd3bf85441b42f2c9
https://pubmed.ncbi.nlm.nih.gov/16461946
https://pubmed.ncbi.nlm.nih.gov/16461946
Autor:
Ryan M. Boomer, Markus Kurz, Scott D. Lewis, Thomas Green Mccauley, Charles Wilson, Judith M. Healy
Publikováno v:
Oligonucleotides. 15(3)
Here, we examine biodistribution of radiolabeled aptamers and assess the relative ability of different stabilized aptamer compositions (mixed 2'-F/2'-O-Me; fully 2'-O-Me modified) to access inflamed tissues in a murine inflammation model. Biodistribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4706219149c3844706803f843b5ed11
https://pubmed.ncbi.nlm.nih.gov/16201906
https://pubmed.ncbi.nlm.nih.gov/16201906
Autor:
Judith M Healy, Paul Dugdale
Publikováno v:
Medical Journal of Australia. 188:549-550
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2240a455fd4621409ba266773eedfcdd
https://doi.org/10.5694/j.1326-5377.2008.tb01782.x
https://doi.org/10.5694/j.1326-5377.2008.tb01782.x