Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Judith M. Cosgrove"'
Autor:
Michael Raymond Makowski, David W. Piotrowski, Judith M. Cosgrove, John Litchfield, Claire M. Steppan, Janice A. Brown, Constantin Neagu, Yue Chen, Ping Du, David Austen Perry, Kelly A. Martin, Thomas J. McLellan, Richard V. Trilles, Karen Atkinson, Mayda Castrodad, Elena E. Beretta
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1621-1625
A potent, small molecule inhibitor with a favorable pharmacokinetic profile to allow for sustained SCD inhibition in vivo was identified. Starting from a low MW acyl guanidine (5a), identified with a RapidFire High-Throughput Mass Spectrometry (RF-MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc68ce50aec716130464effe4b0fa70
https://doi.org/10.1016/j.bmcl.2011.01.113
https://doi.org/10.1016/j.bmcl.2011.01.113
Autor:
Tara B. Manion, Ralph P. Robinson, Jeremy A. Bartlett, Brenda Ramos, Angela Wolford, Alfin D. N. Vaz, Andrew J. Bessire, David A. Tess, Peter Bertinato, Theodore J. Schmahai, Judith M. Cosgrove, Matthew R. Reese, Swick Andrew Gordon, Patrick M. Foley, Martha L. Minich
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(14)
Analogues related to dirlotapide (1), a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) were prepared with the goal of further reducing the potential for unwanted liver MTP inhibition and associated side-effects. Compounds w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89de21cee9b83d020f1ca9b5ecba3ee
https://pubmed.ncbi.nlm.nih.gov/21684740
https://pubmed.ncbi.nlm.nih.gov/21684740
Publikováno v:
Biochemical and Biophysical Research Communications. 154:1280-1286
The isoquinolinesulfonamide PKC inhibitors H-7 and H-8 inhibit primary, in vivo generated cytotoxic T lymphocyte (CTL) activity by 50% at concentrations approximating their reported Ki values for PKC, 6 uM and 15 uM respectively. However, a greater t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036946cce6e9ca7d72d8d9051c10acb5
https://doi.org/10.1016/0006-291x(88)90278-1
https://doi.org/10.1016/0006-291x(88)90278-1