Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Judith M. A. Emmen"'
Autor:
Antine W. Flikweert, Anneke C. Muller Kobold, Simone van der Sar-van der Brugge, Peter Heeringa, Izabela A. Rodenhuis-Zybert, Johan Bijzet, Adriana Tami, Bernardina T. F. van der Gun, Karin I. Wold, Anke Huckriede, Hildegard Franke, Judith M. A. Emmen, Marloes Emous, Marco J. J. H. Grootenboers, Matijs van Meurs, Peter H. J. van der Voort, Jill Moser
Publikováno v:
International Journal of Obesity, 47, 126-137. Nature Publishing Group
Background Obesity is a risk factor for adverse outcomes in COVID-19, potentially driven by chronic inflammatory state due to dysregulated secretion of adipokines and cytokines. We investigated the association between plasma adipokines and COVID-19 s
Autor:
Arjen-Kars Boer, Johannes M.W. van den Ouweland, Huib L. Vader, Judith M A Emmen, Jos P.M. Wielders
Publikováno v:
Clinical Chemistry and Laboratory Medicine (CCLM). 50:1969-1972
Background: Measurement of serum 25-hydroxyvitamin D [25(OH)D] is used to assess vitamin D status. We evaluated the analytical performance of a new automated assay, Elecsys Vitamin D Total (Roche Diagnostics, Mannheim, Germany), based on competitive
Autor:
K. Pieterse, Dirk Leysen, Luc Roumen, Jos F.M. Smits, Judith M. A. Emmen, Peter A. J. Hilbers, Marcel E. de Gooyer, Erica M. G. Custers, Ilona P. E. Beugels, Marijn P. A. Sanders, Harry C. J. Ottenheijm, Johannes Jozeph Robertus Maria Hermans, Ralf Plate
Publikováno v:
Journal of Computer-Aided Molecular Design, 21(8), 455-471. Springer
Journal of Computer-Aided Molecular Design
Journal of Computer-Aided Molecular Design
Aldosterone is synthesised by aldosterone synthase (CYP11B2). CYP11B2 has a highly homologous isoform, steroid 11beta-hydroxylase (CYP11B1), which is responsible for the biosynthesis of aldosterone precursors and glucocorticoids. To investigate aldos
Autor:
John F. Couse, Karina F. Rodriguez, Judith M. A. Emmen, Donald Poirier, Fuminori Taniguchi, Kenneth S. Korach
Publikováno v:
The FASEB Journal. 21:586-595
Excess androgen synthesis by thecal cells is invariably detrimental to preovulatory follicles in the ovary and is considered a fundamental characteristic of polycystic ovary syndrome in women. Investigators have long postulated that granulosa cell-de
Autor:
Mariana M. Yates, Susan A. Elmore, John F. Couse, Judith M. A. Emmen, Kenneth S. Korach, Grace E. Kissling
Publikováno v:
Endocrinology. 146:2817-2826
Both estrogen receptor (ER) alpha and beta are expressed within the ovary and lack of either of these receptors affects ovarian function. In this study, the role of ERalpha and ERbeta in folliculogenesis and ovulation was further analyzed. Evaluation
Autor:
Judith M. A. Emmen, J. A. Grootegoed, Ibrahim M. Adham, Wolfgang Engel, Albert O. Brinkmann, Anke McLuskey
Publikováno v:
Endocrinology. 141:4720-4727
The gubernaculum connects the gonad to the inguinoscrotal region and is involved in testis descent. It rapidly develops in the male fetus, whereas development in the female fetus is lacking. Possible factors involved in gubernaculum development are a
Publikováno v:
Molecular and Cellular Endocrinology, 160, 11-16. Elsevier Ireland Ltd
INSL3, also designated Leydig insulin-like (Ley I-L) or relaxin-like factor (RLF), belongs to the insulin-like hormone superfamily. It is expressed in pre- and postnatal Leydig cells of the testis and in postnatal theca cells of the ovary. This sexua
Autor:
Erica M. G. Custers, Luc Roumen, Marcel E. de Gooyer, Ralf Plate, Harry C. J. Ottenheijm, Judith M. A. Emmen, K. Pieterse, Dirk Leysen, Peter A. J. Hilbers, Ilona P. E. Beugels, J. J. Rob Hermans, Bram van Hoof, Jos F.M. Smits
Publikováno v:
Journal of Computational Chemistry, 32(11), 2441-2448. Wiley-Blackwell
Journal of Computational Chemistry, 32(11), 2441-2448. Wiley
Journal of Computational Chemistry, 32(11), 2441-2448. Wiley
The biosynthesis of the mineralocorticoid hormone aldosterone involves a multistep hydroxylation of 11-deoxycorticosterone at the 11- and 18-positions, resulting in the formation of corticosterone and 18-hydroxycorticosterone, the final precursor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd9b8df8da8cc9a484d4f12d868d619
https://cris.maastrichtuniversity.nl/en/publications/8e9b97b9-0f8e-4a03-9fa7-a8f7248daf15
https://cris.maastrichtuniversity.nl/en/publications/8e9b97b9-0f8e-4a03-9fa7-a8f7248daf15
Autor:
Harry C. J. Ottenheijm, Dirk Leysen, Joris W. Peeters, J. J. Rob Hermans, Erica M. G. Custers, Henk M. Janssen, Luc Roumen, Marcel E. de Gooyer, Jef A. J. M. Vekemans, Peter A. J. Hilbers, Judith M. A. Emmen, K. Pieterse, Ralf Plate, Ilona P. E. Beugels, Jos F.M. Smits
Publikováno v:
Journal of Medicinal Chemistry, 53(4), 1712-1725. American Chemical Society
Reducing aldosterone action is beneficial in various major diseases such as heart failure. Currently, this is achieved with mineralocorticoid receptor antagonists, however, aldosterone synthase (CYP11B2) inhibitors may offer a promising alternative.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2517b247012fcd2d435f694d8b894337
https://cris.maastrichtuniversity.nl/en/publications/a80ac6b8-2d90-4e78-8582-9517f101f4d7
https://cris.maastrichtuniversity.nl/en/publications/a80ac6b8-2d90-4e78-8582-9517f101f4d7
Autor:
Luc Roumen, Peter A. J. Hilbers, Marcel E. de Gooyer, Monica Minnaard-Huiban, Harry C. J. Ottenheijm, Jos F.M. Smits, Ilona P. E. Beugels, Ralf Plate, Judith M. A. Emmen, Eveline Ruijters, Géraldine M. S. Cohuet, J. J. Rob Hermans, Helma van Essen, K. Pieterse
Publikováno v:
Endocrinology, 149(1), 28-31. Endocrine Society
Reversal of cardiac fibrosis is a major determinant of the salutary effects of mineralocorticoid receptor antagonists in heart failure. Recently, R-fadrozole was coined as an aldosterone biosynthesis inhibitor, offering an appealing alternative to mi