Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Judith M White"'
Autor:
Kelly Drews, Michael P Calgi, William Casey Harrison, Camille M Drews, Pedro Costa-Pinheiro, Jeremy Joseph Porter Shaw, Kendra A Jobe, John D Han, Todd E Fox, Judith M White, Mark Kester
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228735 (2020)
Influenza virus is an enveloped virus wrapped in a lipid bilayer derived from the host cell plasma membrane. Infection by influenza virus is dependent on these host cell lipids, which include sphingolipids. Here we examined the role of the sphingolip
Externí odkaz:
https://doaj.org/article/5b14755e8b19477ea508fe6d64f8e37f
Autor:
Evelyn M Covés-Datson, Julie Dyall, Lisa Evans DeWald, Steven R King, Derek Dube, Maureen Legendre, Elizabeth Nelson, Kelly C Drews, Robin Gross, Dawn M Gerhardt, Lisa Torzewski, Elena Postnikova, Janie Y Liang, Bhupal Ban, Jagathpala Shetty, Lisa E Hensley, Peter B Jahrling, Gene G Olinger, Judith M White, David M Markovitz
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007595 (2019)
Ebolaviruses cause an often rapidly fatal syndrome known as Ebola virus disease (EVD), with average case fatality rates of ~50%. There is no licensed vaccine or treatment for EVD, underscoring the urgent need to develop new anti-ebolavirus agents, es
Externí odkaz:
https://doaj.org/article/be3daa2799a548df9e5ee6400d5ad727
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219312 (2019)
Ebolaviruses continue to inflict horrific disease and instill fear. The 2013-2016 outbreak in Western Africa caused unfathomable morbidity and mortality (over 11,000 deaths), and the second largest outbreak is on-going in the Democratic Republic of t
Externí odkaz:
https://doaj.org/article/97cdf812cf7a46d6a32f9984d40b63b7
Autor:
Elizabeth A Nelson, Julie Dyall, Thomas Hoenen, Alyson B Barnes, Huanying Zhou, Janie Y Liang, Julia Michelotti, William H Dewey, Lisa Evans DeWald, Richard S Bennett, Patrick J Morris, Rajarshi Guha, Carleen Klumpp-Thomas, Crystal McKnight, Yu-Chi Chen, Xin Xu, Amy Wang, Emma Hughes, Scott Martin, Craig Thomas, Peter B Jahrling, Lisa E Hensley, Gene G Olinger, Judith M White
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005540 (2017)
Phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) is a lipid kinase involved in endosome maturation that emerged from a haploid genetic screen as being required for Ebola virus (EBOV) infection. Here we analyzed the effects of apilimod, a PIKfyve i
Externí odkaz:
https://doaj.org/article/19a1dce2d6914c7dbc9521614d84c222
Autor:
Shadisadat Esmaeili, Katherine Owens, Jessica Wagoner, Stephen J. Polyak, Judith M. White, Joshua T. Schiffer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract In a pivotal trial (EPIC-HR), a 5-day course of oral ritonavir-boosted nirmatrelvir, given early during symptomatic SARS-CoV-2 infection (within three days of symptoms onset), decreased hospitalization and death by 89.1% and nasal viral load
Externí odkaz:
https://doaj.org/article/a3c14c64f2be4649b856e144e4a66648
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152527 (2016)
Ebola virus (EBOV) enters cells from late endosomes/lysosomes under mildly acidic conditions. Entry by fusion with the endosomal membrane requires the fusion loop (FL, residues 507-560) of the EBOV surface glycoprotein to undergo a pH-dependent confo
Externí odkaz:
https://doaj.org/article/9da00d73077e4807855666d69143221e
Autor:
Charles J Shoemaker, Kathryn L Schornberg, Sue E Delos, Corinne Scully, Hassan Pajouhesh, Gene G Olinger, Lisa M Johansen, Judith M White
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56265 (2013)
Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providin
Externí odkaz:
https://doaj.org/article/e41b76c3bdb5499fbd5498b5ccc2905a
Publikováno v:
PLoS Pathogens, Vol 6, Iss 7, p e1000994 (2010)
To study VSV entry and the fate of incoming matrix (M) protein during virus uncoating we used recombinant viruses encoding M proteins with a C-terminal tetracysteine tag that could be fluorescently labeled using biarsenical (Lumio) compounds. We foun
Externí odkaz:
https://doaj.org/article/358652ce01274b099b040ab1d9933918
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Ebola virus (EBOV) causes a hemorrhagic fever with fatality rates up to 90%. The EBOV entry process is complex and incompletely understood. Following attachment to host cells, EBOV is trafficked to late endosomes/lysosomes where its glycopro
Externí odkaz:
https://doaj.org/article/520065fb1dde4d3982eafd6a4d0f4c31
Autor:
Amanda E. Ward, Daria Sokovikova, M. Neal Waxham, Frederick A. Heberle, Ilya Levental, Kandice R. Levental, Volker Kiessling, Judith M. White, Lukas K. Tamm
Publikováno v:
ACS Infectious Diseases. 9:773-784
The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their infection by an incompletely understood mechanism. We have previously reported that Serinc5 but not its paralogue, Serinc2, blocks HIV cell entry by memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379eb6b725c39b57432eb376bdd1a0d6
https://doi.org/10.1021/acsinfecdis.2c00478
https://doi.org/10.1021/acsinfecdis.2c00478