Productive homologous and non-homologous recombination of hepatitis C virus in cell culture.

Autor: Troels K H Scheel, Andrea Galli, Yi-Ping Li, Lotte S Mikkelsen, Judith M Gottwein, Jens Bukh

Publikováno v: PLoS Pathogens, Vol 9, Iss 3, p e1003228 (2013)

Genetic recombination is an important mechanism for increasing diversity of RNA viruses, and constitutes a viral escape mechanism to host immune responses and to treatment with antiviral compounds. Although rare, epidemiologically important hepatitis

Externí odkaz: https://doaj.org/article/62ceabffd31041f089cd5936d2865f60

Identification of novel neutralizing determinants for protection against HCV

Autor: Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein

Publikováno v: Alzua, G P, Pihl, A F, Offersgaard, A, Velázquez-Moctezuma, R, Duarte Hernandez, C R, Augestad, E H, Fahnøe, U, Mathiesen, C K, Krarup, H, Law, M, Prentoe, J, Bukh, J & Gottwein, J M 2023, ' Identification of novel neutralizing determinants for protection against HCV ', Hepatology, vol. 73, no. 3, pp. 982-996 . https://doi.org/10.1002/hep.32772
Alzua, G P, Pihl, A F, Offersgaard, A, Velázquez-Moctezuma, R, Hernandez, C R D, Augestad, E H, Fahnøe, U, Mathiesen, C K, Krarup, H, Law, M, Prentoe, J, Bukh, J & Gottwein, J M 2023, ' Identification of novel neutralizing determinants for protection against HCV ', Hepatology, vol. 77, no. 3, pp. 982-996 . https://doi.org/10.1002/hep.32772

BACKGROUND AND AIMS: HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine. N-linked glycosylation of viral envelope proteins is a key mechanism for such evasio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee8ddda5099418631770b24f323c860
https://curis.ku.dk/portal/da/publications/identification-of-novel-neutralizing-determinants-for-protection-against-hcv(8ae9404e-763e-4513-aa0e-d6bc1800cc97).html

Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication

Autor: Ulrik Fahnøe, Long V. Pham, Carlota Fernandez-Antunez, Rui Costa, Lizandro René Rivera-Rangel, Andrea Galli, Shan Feng, Lotte S. Mikkelsen, Judith M. Gottwein, Troels K. H. Scheel, Santseharay Ramirez, Jens Bukh

Publikováno v: Viruses; Volume 14; Issue 2; Pages: 172
Fahnøe, U, Pham, L V, Fernandez-Antunez, C, Costa, R, Rivera-Rangel, L R, Galli, A, Feng, S, Mikkelsen, L S, Gottwein, J M, Scheel, T K H, Ramirez, S & Bukh, J 2022, ' Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication ', Viruses, vol. 14, no. 2, 172 . https://doi.org/10.3390/v14020172

The COVID-19 pandemic continues to threaten healthcare systems worldwide due to the limited access to vaccines, suboptimal treatment options, and the continuous emergence of new and more transmissible SARS-CoV-2 variants. Reverse-genetics studies of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b3ef4a53c867e02565a0bbfcb6dabe
https://pubmed.ncbi.nlm.nih.gov/35215765

Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral Replication

Autor: Jens Bukh, Carlota Fernandez-Antunez, Nina Weis, Andrea Galli, Line Abildgaard Ryberg, Jean Dubuisson, Alexander Underwood, Christina Sølund, Martin Schou Pedersen, Long V. Pham, Santseharay Ramirez, Judith M. Gottwein, Lotte S. Mikkelsen, Sandrine Belouzard, Shan Feng, Ulrik Fahnøe

Publikováno v: Antimicrobial Agents and Chemotherapy

Efforts to mitigate the coronavirus disease 2019 (COVID-19) pandemic include the screening of existing antiviral molecules that could be repurposed to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Although SARS-CoV-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38f190592ca838344e00c226ceb332a
https://doi.org/10.1128/aac.00097-21

In vitro efficacy of artemisinin-based treatments against SARS-CoV-2

Autor: Santseharay Ramirez, Judith M. Gottwein, Klaus Osterrieder, Long V. Pham, Yuyong Zhou, Eva Settels, Shan Feng, Kerry Gilmore, Ulrik Fahnøe, Jens Bukh, Peter H. Seeberger, Karen A. Gammeltoft, Jakob Trimpert, Anna Offersgaard

Publikováno v: Scientific Reports
Zhou, Y, Gilmore, K, Ramirez, S, Settels, E, Gammeltoft, K A, Pham, L V, Fahnøe, U, Feng, S, Offersgaard, A, Trimpert, J, Bukh, J, Osterrieder, K, Gottwein, J M & Seeberger, P H 2021, ' In vitro efficacy of artemisinin-based treatments against SARS-CoV-2 ', Scientific Reports, vol. 11, 14571 . https://doi.org/10.1038/s41598-021-93361-y
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Effective and affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are needed. We report in vitro efficacy of Artemisia annua extracts as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db07490a9f3be82794a48f3a2b749710
https://hdl.handle.net/21.11116/0000-0008-EE13-721.11116/0000-0008-EE0F-D