Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Judith Leibovici"'
Autor:
Judith Sinai, Annette Siegal, Tatiana Kaptzan, Monica Huszar, Ehud Skutelsky, Judith Leibovici, Orit Itzhaki, Ginnette Schiby, M. Michowitz
Publikováno v:
Experimental Gerontology. 43:164-175
Numerous data demonstrate a lower aggressiveness of tumors in aged as compared to young patients. The mechanisms underlying this phenomenon have not yet been completely elucidated. Several mechanisms have been shown, such as reduced tumor cell prolif
Publikováno v:
Cancer Investigation. 19:791-798
The effect of hyperthermic treatment on AKR lymphoma cells of varying malignancy was investigated. Tumor cells were pretreated at 37 or 43 degrees C and then injected to mice. The effect on the highly malignant variant, TAU-38, was compared to that o
Autor:
Dina Katzenelson, Asher Pinchassov, M. Michowitz, Jehuda Hiss, S Kay, Ginnette Schibi, Natalie Donin, Judith Leibovici
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1497:37-50
Disturbance of apoptosis is an established factor in tumorigenesis. The role of apoptosis in tumor progression is not yet clear. In the present study we compared the tendency to spontaneous apoptosis (and the proliferative capacity) of tumor cells de
Autor:
Natalie Donin, S Kay, M. Michowitz, Judith Sinai, Judith Leibovici, Ginnette Schibi, Annette Siegal, Dina Katzenelson
Publikováno v:
Cancer Investigation. 18:702-714
Dysregulation in apoptotic cell death has recently emerged as a factor in tumorigenesis, but its effect in tumor progression is not yet established. In the present study we evaluated the levels of proliferative and apoptotic cell fractions in a T-cel
Autor:
J Ravia, Asher Pinchassov, M. Michowitz, Dina Katzenelson, Judith Leibovici, Natalie Donin, Judith Sinai, Annette Siegal, S Kay
Publikováno v:
APOPTOSIS. 4:429-440
Resistance to apoptosis may be related to tumor progression, due to the implications it might have on both tumor mass and genetic instability. We compared the tendency to spontaneous apoptosis and the proliferative capacity of metastatic growths of s
Autor:
J Ravia, Jehuda Hiss, M. Michowitz, Ginnette Schiby, Dina Katzenelson, Judith Leibovici, Judith Sinai, Natalie Donin, S Kay
Publikováno v:
Apoptosis. 2:214-220
The possibility that apoptosis and/or cell proliferation have a role in tumour progression in a murine T cell lymphoma was tested. The model consisted of the comparison of primary (PT) and metastatic tumour (MT) cells. The PT cells, but not the MT ce
Autor:
Judith Sinai, Alexander N. Staroselsky, Jardena Nordenberg, Natalie Donin, Judith Leibovici, Tatiana Mahlin
Publikováno v:
Cancer Investigation. 15:416-421
The rise of cancer frequency as a function of age is a well-established fact. The aspect of the host age-tumor progression relationship, namely the slower metastatic spread in aged patients, has been investigated to a lesser extent. In the present st
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1281(2):182-188
Counteraction of drug resistance is a major challenge in cancer therapy, particularly in adhanced stages. The main mechanism of multidrug resistance is related to an increased drug efflux. In the present study we examined the effect of modifying cell
Autor:
Judith Leibovici, Ofir Klein, Y. Wollman, Monica Huszar, Alexander N. Staroselsky, N. Savion, Natalie Donin
Publikováno v:
Cancer Letters. 101:219-225
The metastatic phenotype is of extreme complexity. To complete all the stages of metastasis, the tumor cell must possess a whole series of functional abilities. Multiple biological markers are therefore needed to achieve a deeper understanding of the
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1201:173-178
Ovarian cancer has the highest mortality rate of all gynecological malignancies probably due to the evolution of clones resistant to cytotoxic drugs. Exploring possibilities to overcome such resistance constitutes a challenge in this study. We presen