Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Judith L. Treadway"'
Autor:
H. James Harwood, Jr., Stephen F. Petras, Dennis J. Hoover, Dayna C. Mankowski, Victor F. Soliman, Eliot D. Sugarman, Bernard Hulin, Younggil Kwon, E. Michael Gibbs, James T. Mayne, Judith L. Treadway
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 3, Pp 547-563 (2005)
Diabetic dyslipidemia requires simultaneous treatment with hypoglycemic agents and lipid-modulating drugs. We recently described glycogen phosphorylase inhibitors that reduce glycogenolysis in cells and lower plasma glucose in ob/ob mice (J. Med. Che
Externí odkaz:
https://doaj.org/article/5ebbe43f58a84c83843fcaee4e9c9fbd
Autor:
Ahmed E Enayetallah, Daniel Ziemek, Michael T Leininger, Ranjit Randhawa, Jianxin Yang, Tara B Manion, Dawn E Mather, William J Zavadoski, Max Kuhn, Judith L Treadway, Shelly Ann G des Etages, E Michael Gibbs, Nigel Greene, Claire M Steppan
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27009 (2011)
Triglyceride accumulation is associated with obesity and type 2 diabetes. Genetic disruption of diacylglycerol acyltransferase 1 (DGAT1), which catalyzes the final reaction of triglyceride synthesis, confers dramatic resistance to high-fat diet induc
Externí odkaz:
https://doaj.org/article/5661590c2bdc4b59b1a5d3906590a54f
Autor:
Yu-Shin Ding, Gary W. Cline, Judith L. Treadway, Sarita Naik, Kitt Falk Petersen, Shu-fei Lin, Marc D. Normandin, Kevan C. Herold, Daniel Skovronsky, Roberto A. Calle, Krista Fowles, Timothy J. McCarthy, Richard E. Carson
Publikováno v:
Journal of Nuclear Medicine. 53:908-916
The ability to noninvasively measure endogenous pancreatic b-cell mass (BCM) would accelerate research on the pathophysiology of diabetes and revolutionize the preclinical development of new treatments, the clinical assessment of therapeutic efficacy
Autor:
Jing Chen, Spiros Liras, Manthena V.S. Varma, Judith L. Treadway, Martha L. Minich, Laurel Sweet, John D. Knafels, Karen Atkinson, Nahor Haddish-Berhane, Angel Guzman-Perez, Benjamin D. Stevens, Alan Robertson, Sharad B. Murdande, David B. Duignan, Mark Ammirati, Timothy P. Rolph, William J. Zavadoski, Christopher S. Jones, Patricia Bourassa, Jeffrey A. Pfefferkorn, John Litchfield, Lili Yao, Kevin J. Filipski, Margit MacDougall, Levenia Baker, John C. Pettersen, Theresa D’Aquila, Ayman El-Kattan, Bo Feng, Francis Bourbonais, Meihua Tu, Robert J. Aiello, Gary Erik Aspnes, Jianwei Bian, David R. Derksen, Paul DaSilva-Jardine, Beijing Tan, James A. Landro, Over Cabrera, Rachel E. Kosa, Hud Lawrence Risley, Shenping Liu, Amanda L. Lapworth, Nicole Barucci
Publikováno v:
Journal of Medicinal Chemistry. 55:1318-1333
Glucokinase is a key regulator of glucose homeostasis, and small molecule allosteric activators of this enzyme represent a promising opportunity for the treatment of type 2 diabetes. Systemically acting glucokinase activators (liver and pancreas) hav
Autor:
Karen L. Houseknecht, Tracy P. Torres, Masakazu Shiota, Richard L. Printz, E. P. Donahue, Judith L. Treadway, Yuka Fujimoto
Publikováno v:
Diabetes
OBJECTIVE Examine whether normalizing net hepatic glycogenesis restores endogenous glucose production and hepatic glucose phosphorylation in response to diabetic levels of plasma glucose and insulin in Zucker diabetic fatty rats (ZDF). RESEARCH DESIG
Autor:
Noriyasu Sasaki, Masakazu Shiota, Tracy P. Torres, Alan D. Cherrington, Richard L. Printz, Judith L. Treadway, E. Patrick Donahue, Brooks Lacy
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 337:610-620
The effects of a glycogen phosphorylase inhibitor (GPI) and metformin (MT) on hepatic glucose fluxes (μmol · kg(-1) · min(-1)) in the presence of basal and 4-fold basal levels of plasma glucagon were investigated in 18-h fasted conscious dogs. Com
Autor:
Yiyun Huang, Walter C. Soeller, David Labaree, Richard E. Carson, Jim Ropchan, Nabeel Nabulsi, Shu-fei Lin, Marc D. Normandin, Gary W. Cline, Judith L. Treadway, Tarun Singhal, David Weinzimmer, Yu-Shin Ding, Marc B. Skaddan
Publikováno v:
Molecular Imaging and Biology. 13:973-984
The aim of this study is to compare the utility of two positron emission tomography (PET) imaging ligands ((+)-[(11)C]dihydrotetrabenazine ([(11)C]DTBZ) and the fluoropropyl analog ([(18)F]FP-(+)-DTBZ)) that target islet β-cell vesicular monoamine t
Autor:
Jianxin Yang, Vishwas M. Paralkar, Donna Marie Stone, Tracey Clark, Yasmina Noubia Abdiche, Alison Betts, Mei Li, Michael A Giovanelli, Judith L. Treadway
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 333:2-13
PF-04840082 is a humanized prototype anti-Dickkopf-1 (Dkk-1) immunoglobulin isotype G(2) (IgG(2)) antibody for the treatment of osteoporosis. In vitro, PF-04840082 binds to human, monkey, rat, and mouse Dkk-1 with high affinity. After administration
Autor:
Judith L. Treadway, David W. Piotrowski, R. Kirk McPherson, Jana Polivkova, Anne M. Brodeur, Shenping Liu, Bernard Hulin, David D. Boyer, Stephen J. Orena, Xiayang Qiu, Maria A. Vanvolkenburg, Dennis E. Danley, Donald C. Wilder, Janice C. Parker, Shawn D. Doran, Carolyn B. Soglia, Mark Ammirati, Kim M. Andrews
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1991-1995
A series of 4-substituted proline amides was synthesized and evaluated as inhibitors of dipeptidyl pepdidase IV for the treatment of type 2 diabetes. (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methan
Publikováno v:
FEBS Letters. 581:4749-4753
The inhibition of hepatic glycogen-associated protein phosphatase-1 (PP1-G(L)) by glycogen phosphorylase a prevents the dephosphorylation and activation of glycogen synthase, suppressing glycogen synthesis when glycogenolysis is activated. Here, we s