Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Judith L Treadway"'
1
Akademický článek
Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform.
Autor: Ahmed E Enayetallah, Daniel Ziemek, Michael T Leininger, Ranjit Randhawa, Jianxin Yang, Tara B Manion, Dawn E Mather, William J Zavadoski, Max Kuhn, Judith L Treadway, Shelly Ann G des Etages, E Michael Gibbs, Nigel Greene, Claire M Steppan
Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27009 (2011)
Triglyceride accumulation is associated with obesity and type 2 diabetes. Genetic disruption of diacylglycerol acyltransferase 1 (DGAT1), which catalyzes the final reaction of triglyceride synthesis, confers dramatic resistance to high-fat diet induc
Externí odkaz: https://doaj.org/article/5661590c2bdc4b59b1a5d3906590a54f
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2
Akademický článek
Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase
Autor: H. James Harwood, Jr., Stephen F. Petras, Dennis J. Hoover, Dayna C. Mankowski, Victor F. Soliman, Eliot D. Sugarman, Bernard Hulin, Younggil Kwon, E. Michael Gibbs, James T. Mayne, Judith L. Treadway
Publikováno v: Journal of Lipid Research, Vol 46, Iss 3, Pp 547-563 (2005)
Diabetic dyslipidemia requires simultaneous treatment with hypoglycemic agents and lipid-modulating drugs. We recently described glycogen phosphorylase inhibitors that reduce glycogenolysis in cells and lower plasma glucose in ob/ob mice (J. Med. Che
Externí odkaz: https://doaj.org/article/5ebbe43f58a84c83843fcaee4e9c9fbd
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3
In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PET
Autor: Yu-Shin Ding, Gary W. Cline, Judith L. Treadway, Sarita Naik, Kitt Falk Petersen, Shu-fei Lin, Marc D. Normandin, Kevan C. Herold, Daniel Skovronsky, Roberto A. Calle, Krista Fowles, Timothy J. McCarthy, Richard E. Carson
Publikováno v: Journal of Nuclear Medicine. 53:908-916
The ability to noninvasively measure endogenous pancreatic b-cell mass (BCM) would accelerate research on the pathophysiology of diabetes and revolutionize the preclinical development of new treatments, the clinical assessment of therapeutic efficacy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b853acd60196a1216065c352e9e30cf3
https://doi.org/10.2967/jnumed.111.100545
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5
Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats
Autor: Karen L. Houseknecht, Tracy P. Torres, Masakazu Shiota, Richard L. Printz, E. P. Donahue, Judith L. Treadway, Yuka Fujimoto
Publikováno v: Diabetes
OBJECTIVE Examine whether normalizing net hepatic glycogenesis restores endogenous glucose production and hepatic glucose phosphorylation in response to diabetic levels of plasma glucose and insulin in Zucker diabetic fatty rats (ZDF). RESEARCH DESIG
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cbe87d8f40c220a0d32dc70bca17e5
https://doi.org/10.2337/db09-1156
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6
Impact of a Glycogen Phosphorylase Inhibitor and Metformin on Basal and Glucagon-Stimulated Hepatic Glucose Flux in Conscious Dogs
Autor: Noriyasu Sasaki, Masakazu Shiota, Tracy P. Torres, Alan D. Cherrington, Richard L. Printz, Judith L. Treadway, E. Patrick Donahue, Brooks Lacy
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 337:610-620
The effects of a glycogen phosphorylase inhibitor (GPI) and metformin (MT) on hepatic glucose fluxes (μmol · kg(-1) · min(-1)) in the presence of basal and 4-fold basal levels of plasma glucagon were investigated in 18-h fasted conscious dogs. Com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6f55784e86ee0de0315f0cab99b016
https://doi.org/10.1124/jpet.110.177899
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7
Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes
Autor: Yiyun Huang, Walter C. Soeller, David Labaree, Richard E. Carson, Jim Ropchan, Nabeel Nabulsi, Shu-fei Lin, Marc D. Normandin, Gary W. Cline, Judith L. Treadway, Tarun Singhal, David Weinzimmer, Yu-Shin Ding, Marc B. Skaddan
Publikováno v: Molecular Imaging and Biology. 13:973-984
The aim of this study is to compare the utility of two positron emission tomography (PET) imaging ligands ((+)-[(11)C]dihydrotetrabenazine ([(11)C]DTBZ) and the fluoropropyl analog ([(18)F]FP-(+)-DTBZ)) that target islet β-cell vesicular monoamine t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc139ba744bed9813058679126734aa
https://doi.org/10.1007/s11307-010-0406-x
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8
The Application of Target Information and Preclinical Pharmacokinetic/Pharmacodynamic Modeling in Predicting Clinical Doses of a Dickkopf-1 Antibody for Osteoporosis
Autor: Jianxin Yang, Vishwas M. Paralkar, Donna Marie Stone, Tracey Clark, Yasmina Noubia Abdiche, Alison Betts, Mei Li, Michael A Giovanelli, Judith L. Treadway
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 333:2-13
PF-04840082 is a humanized prototype anti-Dickkopf-1 (Dkk-1) immunoglobulin isotype G(2) (IgG(2)) antibody for the treatment of osteoporosis. In vitro, PF-04840082 binds to human, monkey, rat, and mouse Dkk-1 with high affinity. After administration
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6db23c52d9d7dce200299e7d68b9a06
https://doi.org/10.1124/jpet.109.164129
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10
The hepatic PP1 glycogen-targeting subunit interaction with phosphorylaseacan be blocked by C-terminal tyrosine deletion or an indole drug
Autor: Judith L. Treadway, Irene Hallyburton, Shonagh Munro, Ian R. Kelsall, Patricia T.W. Cohen
Publikováno v: FEBS Letters. 581:4749-4753
The inhibition of hepatic glycogen-associated protein phosphatase-1 (PP1-G(L)) by glycogen phosphorylase a prevents the dephosphorylation and activation of glycogen synthase, suppressing glycogen synthesis when glycogenolysis is activated. Here, we s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e656434cadbff5985bca803ea810eb2
https://doi.org/10.1016/j.febslet.2007.08.073
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