Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms

Autor: Nicolas Szabo-Fresnais, Faiyaz Ahmad, Roger J. Hajjar, Changwon Kho, Mark Hazel, Fabrice Vandeput, Matthew A. Movsesian, Judith Krall, Allan J. Dunlop, Miles D. Houslay, James A. Wohlschlegel, Vincent C. Manganiello, Ahyoung Lee

Publikováno v: Proceedings of the National Academy of Sciences. 110:19778-19783

Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use increases mortality in patients with heart failure. Two isoforms in cardiac myocytes, PDE3A1 and PDE3A2, have identical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2daeb8abfda84511fc531ab4da5d786b
https://doi.org/10.1073/pnas.1305427110

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

Autor: Judith Krall, Marina Freudzon, Rachael P. Norris, Lisa M. Mehlmann, Laurinda A. Jaffe, William J. Ratzan, Huanchen Wang, Viacheslav O. Nikolaev, Hengming Ke, Matthew A. Movsesian

Publikováno v: Development. 136:1869-1878

Mammalian oocytes are arrested in meiotic prophase by an inhibitory signal from the surrounding somatic cells in the ovarian follicle. In response to luteinizing hormone (LH), which binds to receptors on the somatic cells, the oocyte proceeds to seco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45a05f061a8b3073da3f33f73e7f4e3
https://doi.org/10.1242/dev.035238

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2

Autor: Leonardo Furlan, Stuart A. Nicklin, Frank Gesellchen, Laura Ashley Fields, Ivar Sjaastad, Graham Hamilton, Judith Krall, Matthew A. Movsesian, Giuliano Dodoni, Luisa Mancuso, Manuela Zaccolo, Jan Magnus Aronsen, Craig Livie, Konstantinos Lefkimmiatis, Alessandra Stangherlin, Fabrice Vandeput, Nicolas Szabo-Fresnais, Anna Zoccarato, Yuan Yan Sin, Anna Terrin, Nicoletta C. Surdo, Veronica Corsetti, Delyth Graham, George S. Baillie, He Jiang

Publikováno v: Circulation research. 117(8)

Rationale : Chronic elevation of 3′-5′-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodeling and cardiac hypertrophy. However, enhancement of particular aspects of cAMP/protein kinase A signaling seems to be ben

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97658dd4c46b3d9c9366fedfeaece51
https://pubmed.ncbi.nlm.nih.gov/26243800

Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes

Autor: Judith Krall, Faiyaz Ahmad, Matthew A. Movsesian, Young Hun Choi, Vincent C. Manganiello, Dag Ekholm, Eva Degerman

Publikováno v: Biochemical Journal. 353:41-50

We have identified a new cyclic-nucleotide phosphodiesterase isoform, PDE3A, and cloned its cDNA from cultured aortic myocytes. The nucleotide sequence of its coding region is similar to that of the previously cloned myocardial isoform except for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8ec36a0ce89be14e3c8586bb1183873
https://doi.org/10.1042/bj3530041

Conserved expression and functions of PDE4 in rodent and human heart

Autor: Moses Xie, Colleen Scheitrum, Judith Krall, Matthew A. Movsesian, Marco Conti, Wito Richter

Publikováno v: Richter, Wito; Xie, Moses; Scheitrum, Colleen; Krall, Judith; Movsesian, Matthew A.; & Conti, Marco. (2011). Conserved expression and functions of PDE4 in rodent and human heart. Basic Research in Cardiology, 106(2), pp 249-262. doi: 10.1007/s00395-010-0138-8. Retrieved from: http://www.escholarship.org/uc/item/75c430rd
Basic research in cardiology, vol 106, iss 2
Basic Research in Cardiology

PDE4 isoenzymes are critical in the control of cAMP signaling in rodent cardiac myocytes. Ablation of PDE4 affects multiple key players in excitation–contraction coupling and predisposes mice to the development of heart failure. As little is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7335ba0006537f9a4ad0583c971bfb
http://www.escholarship.org/uc/item/75c430rd