Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Judith Kimble"'
Autor:
Scott Takeo Aoki, Tina R. Lynch, Sarah L. Crittenden, Craig A. Bingman, Marvin Wickens, Judith Kimble
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nematode P granules are cytoplasmic RNA–protein biomolecule condensates central to germ cell development. Here the authors show that dimerization of the PGL-1 scaffolding protein is crucial to granule formation and mRNA repression, and that the WAG
Externí odkaz:
https://doaj.org/article/1fc26fa5125a4471a584495d77e492d1
Autor:
Douglas F. Porter, Aman Prasad, Brian H. Carrick, Peggy Kroll-Connor, Marvin Wickens, Judith Kimble
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 1, Pp 153-165 (2019)
Metazoan PUF (Pumilio and FBF) RNA-binding proteins regulate various biological processes, but a common theme across phylogeny is stem cell regulation. In Caenorhabditis elegans, FBF (fem-3 Binding Factor) maintains germline stem cells regardless of
Externí odkaz:
https://doaj.org/article/4199407a06c44f8ea331e1f7e7f77bb0
Autor:
Scott T. Aoki, Douglas F. Porter, Aman Prasad, Marvin Wickens, Craig A. Bingman, Judith Kimble
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3769-3775 (2018)
Summary: FOG-3 is a master regulator of sperm fate in Caenorhabditis elegans and homologous to Tob/BTG proteins, which in mammals are monomeric adaptors that recruit enzymes to RNA binding proteins. Here, we determine the FOG-3 crystal structure and
Externí odkaz:
https://doaj.org/article/f317025531f3428a9fa1c9ecfd373326
Autor:
Heaji Shin, Kimberly A Haupt, Aaron M Kershner, Peggy Kroll-Conner, Marvin Wickens, Judith Kimble
Publikováno v:
PLoS Genetics, Vol 13, Iss 12, p e1007121 (2017)
Central questions in regenerative biology include how stem cells are maintained and how they transition from self-renewal to differentiation. Germline stem cells (GSCs) in Caeno-rhabditis elegans provide a tractable in vivo model to address these que
Externí odkaz:
https://doaj.org/article/613acff5943f43f4993dc2d191bbc89b
Publikováno v:
Bio-Protocol, Vol 7, Iss 12 (2017)
Single-molecule RNA fluorescence in situ hybridization (smFISH) is a technique to visualize individual RNA molecules using multiple fluorescently-labeled oligonucleotide probes specific to the target RNA (Raj et al., 2008; Lee et al., 2016a). We adap
Externí odkaz:
https://doaj.org/article/48b257ad49b64aab913cb2be92f1d598
Publikováno v:
eLife, Vol 5 (2016)
C. elegans Notch signaling maintains a pool of germline stem cells within their single-celled mesenchymal niche. Here we investigate the Notch transcriptional response in germline stem cells using single-molecule fluorescence in situ hybridization co
Externí odkaz:
https://doaj.org/article/56590abae95c4d91bc2ce30764ada7f1
Autor:
Hannah S Seidel, Judith Kimble
Publikováno v:
eLife, Vol 4 (2015)
Many types of adult stem cells exist in a state of cell-cycle quiescence, yet it has remained unclear whether quiescence plays a role in maintaining the stem cell fate. Here we establish the adult germline of Caenorhabditis elegans as a model for fac
Externí odkaz:
https://doaj.org/article/aa4efdba49294b189f00dfb002c51ec9
Autor:
Judith Kimble, William M Bement, Qiang Chang, Benjamin L Cox, Norman R Drinkwater, Richard L Gourse, Aaron A Hoskins, Anna Huttenlocher, Pamela K Kreeger, Paul F Lambert, Marsha R Mailick, Shigeki Miyamoto, Richard L Moss, Kate M O'Connor-Giles, Avtar Roopra, Krishanu Saha, Hannah S Seidel
Publikováno v:
eLife, Vol 4 (2015)
A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for addressing the problems confronting the biomedical research community in the US.
Externí odkaz:
https://doaj.org/article/977f332b05b245bbb249d515b2ab0389
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139076 (2015)
Growth factors and transcription factors are well known to regulate pluripotent stem cells, but less is known about translational control in stem cells. Here, we use embryonic stem cells (ESCs) to investigate a connection between ESC growth factors a
Externí odkaz:
https://doaj.org/article/99530d42224b4b3f949a32f21aee0454
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88372 (2014)
The mesenchymal distal tip cell (DTC) provides the niche for Caenorhabditis elegans germline stem cells (GSCs). The DTC has a complex cellular architecture: its cell body caps the distal gonadal end and contacts germ cells extensively, but it also in
Externí odkaz:
https://doaj.org/article/bc6e5295a3f94352bb6cbcea3bb38028