Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Judith K. Christman"'
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 43:586-593
Sialyl Lewis X is a tumor-associated antigen frequently found in the advanced cancers. However, the mechanism for the production of this cancer antigen is not entirely clear. The objective of this study is to examine whether epigenetics is involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6766e29464c5c1d6993e8065b054c9
https://doi.org/10.1016/j.biocel.2010.12.015
https://doi.org/10.1016/j.biocel.2010.12.015
Autor:
Yap Ching Chew, Judith K. Christman, Anne M. Ilvarsonn, Stephanie J. Kratzer, David Klinkebiel, John T. West, Joel C. Eissenberg, Bhavana J. Dave, Janos Zempleni
Publikováno v:
The Journal of Nutrition. 138:2316-2322
Transposable elements such as long terminal repeats (LTR) constitute approximately 45% of the human genome; transposition events impair genome stability. Fifty-four promoter-active retrotransposons have been identified in humans. Epigenetic mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea0b0a5182418e0428b3e31eb4002372
https://doi.org/10.3945/jn.108.098673
https://doi.org/10.3945/jn.108.098673
Publikováno v:
Clinical Cancer Research. 11:7033-7041
Purpose: We have previously shown the reactivation of some methylation-silenced genes in cancer cells by (−)-epigallocatechin-3-gallate, the major polyphenol from green tea. To determine whether other polyphenolic compounds have similar activities,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4455a91cce17262fc9d84c47b6d0e8
https://doi.org/10.1158/1078-0432.ccr-05-0406
https://doi.org/10.1158/1078-0432.ccr-05-0406
Autor:
Judith K. Christman
Publikováno v:
Oncogene. 21:5483-5495
5-Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide range of anti-metabolic activities when tested against cultured cancer cells and to be an effective chemotherapeutic agent for acute myelogenous leukemia. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce6144b8773edc5c7d5f00fcf8174fc
https://doi.org/10.1038/sj.onc.1205699
https://doi.org/10.1038/sj.onc.1205699
Publikováno v:
Protein Expression and Purification. 25:31-40
Enzymatic DNA methylation of carbon 5 of cytosines is an epigenetic modification that plays a role in regulating gene expression, differentiation, and tumorigenesis. DNA (cytosine-C5)-methyltransferase-1 is the enzyme responsible for maintaining esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95adef7be6e5ac5833e0498717ad2a6
https://doi.org/10.1006/prep.2001.1606
https://doi.org/10.1006/prep.2001.1606
Autor:
Peiyuan Wang, Adam S. Brank, Marc C. Nicklaus, Alexander D. MacKerell, Victor E. Marquez, Nilesh K. Banavali, Judith K. Christman,‡ and
Publikováno v:
Journal of the American Chemical Society. 122:12422-12434
X-ray crystallographic studies of HhaI DNA (cytosine-C5)-methyltransferase (M.HhaI) covalently linked to methylated 5-fluorocytosine in DNA provided the first direct evidence that the cytosine residue targeted for methylation was “flipped” out of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d813b16002e958b3a2665f7b5f00512b
https://doi.org/10.1021/ja001989s
https://doi.org/10.1021/ja001989s
Autor:
Janice R. Sufrin, Estela Alvarez, Canio J. Marasco, Victor E. Marquez, Xiaodong Cheng, Adam S. Brank, Margaret O'Gara, Harry Ford, Judith K. Christman, Amanda J. Goddard, Gholamreza Sheikhnejad
Publikováno v:
Journal of Molecular Biology. 285:2021-2034
A key step in the predicted mechanism of enzymatic transfer of methyl groups from S-adenosyl- l -methionine (AdoMet) to cytosine residues in DNA is the transient formation of a dihydrocytosine intermediate covalently linked to cysteine in the active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4829e75f565ddb91ce3ae3f0c2544cb5
https://doi.org/10.1006/jmbi.1998.2426
https://doi.org/10.1006/jmbi.1998.2426
Publikováno v:
Proceedings of the National Academy of Sciences. 92:7347-7351
Methylation of cytosine residues in DNA plays an important role in regulating gene expression during vertebrate embryonic development. Conversely, disruption of normal patterns of methylation is common in tumors and occurs early in progression of som
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1922c755552a0bbbcaea0ffd0377e00
https://doi.org/10.1073/pnas.92.16.7347
https://doi.org/10.1073/pnas.92.16.7347
Autor:
Ryan A. Hlady, Lynette M. Smith, Judith K. Christman, Hollie M. Siebler, Shantaram S. Joshi, Javeed Iqbal, Timothy C. Greiner, Kristi M. Anderson, Jana Opavska, Wing C. Chan, Rene Opavsky, David Klinkebiel, Staci L. Peters, Jay Hannah, Dhundy R. Bastola, Dean W. Felsher, Juraj Bies, Oksana Lockridge, Kay Uwe Wagner, Melanie A. Simpson, Slavomíra Nováková
Publikováno v:
The Journal of clinical investigation. 122(1)
DNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation of cytosine residues in mammals. DNA methylation contributes to the epigenetic control of gene transcription and is deregulated in virtually all human tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bb75e0d226b1b176216e0e4e6b0ad7
https://pubmed.ncbi.nlm.nih.gov/22133874
https://pubmed.ncbi.nlm.nih.gov/22133874
Autor:
Gholamreza Sheikhnejad, Susana Abileah, Mei-Ling Chen, Judith K. Christman, Mark Dizik, Elsie Wainfan
Publikováno v:
The Journal of Nutritional Biochemistry. 4:672-680
Methylation of C residues in CpG sites in the regulatory regions of a wide variety of genes has been linked to silencing of their expression. During normal mammalian development, loss of methylation at specific sites accompanies tissue-specific activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0878e15b5220baf897f3663ee58aa80
https://doi.org/10.1016/0955-2863(93)90106-7
https://doi.org/10.1016/0955-2863(93)90106-7