A 3-year evaluation of preclinicaltrials.eu reveals room for improvement in preregistration of animal studies.

Autor: Mira van der Naald, Steven A J Chamuleau, Julia M L Menon, Wim de Leeuw, Judith J de Haan, Dirk J Duncker, Kimberley E Wever

Publikováno v: PLoS Biology, Vol 19, Iss 9, p e3001397 (2021)

In 2018, the first registry dedicated to preregistration of animal study protocols was launched. Despite international support, the overall number of (pre)registered protocols is still low, illustrating the need for pushing the preregistration agenda

Externí odkaz: https://doaj.org/article/7b4fe5d10b654104899ac79fb5e86b92

The transverse aortic constriction heart failure animal model: a systematic review and meta-analysis

Autor: Marissa Bastemeijer, Judith J. de Haan, Joost P.G. Sluijter, Gerard Pasterkamp, Kimberley E. Wever, Lena Bosch, Saskia C.A. de Jager, Margarida Viola, Jennifer J. van der Burg, Erik van der Worp, Clémene Odille, Marian Wesseling, Hamid el Azzouzi

Publikováno v: Heart Failure Reviews
Heart Failure Reviews, 26, 1515-1524
Heart Failure Reviews, 26, 6, pp. 1515-1524

The transverse aortic constriction (TAC) model is frequently used to study adverse cardiac remodeling upon pressure overload. We set out to define the most important characteristics that define the degree of cardiac remodeling in this model. A system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c1d905a1425cdb714207416af55ab9
http://europepmc.org/articles/PMC8510918

CXCL4 drives fibrosis by promoting several key cellular and molecular processes

Autor: Alsya J. Affandi, Tiago Carvalheiro, Andrea Ottria, Judith J. de Haan, Maike A.D. Brans, Maarten M. Brandt, Ralph G. Tieland, Ana P. Lopes, Beatriz Malvar Fernández, Cornelis P.J. Bekker, Maarten van der Linden, Maili Zimmermann, Barbara Giovannone, Catharina G.K. Wichers, Samuel Garcia, Michael de Kok, Giuseppina Stifano, Yan Juan Xu, M. Anna Kowalska, Maaike Waasdorp, Caroline Cheng, Susan Gibbs, Saskia C.A. de Jager, Joel A.G. van Roon, Timothy R.D.J. Radstake, Wioleta Marut

Publikováno v: Cell Reports, 38(1):110189. Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernandez, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Cell Reports, 38(1). Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernández, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189

Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic disease in which CXCL4 is increased and strongly correlates with sk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3b28b93aeccba36fb11cbf7a1fecc6
https://pubmed.ncbi.nlm.nih.gov/34986347

OP0327 Cxcl4 drives fibrosis by promoting several key cellular and molecular processes

Autor: Ralph G. Tieland, S. de Jager, Robert Lafyatis, J.A. van Roon, M. van der Linden, Tiago Carvalheiro, A. Affandi, D.-J. Heijnen, Andrea Ottria, Barbara Giovannone, Maike A.D. Brans, Caroline Cheng, Beatriz Malvar-Fernandez, Judith J. de Haan, A. Kowalska, Cornelis P. J. Bekker, Trdj Radstake, Wioleta Marut, Maarten M. Brandt

Publikováno v: FRIDAY, 15 JUNE 2018.

Background Fibrosis, characterised by excessive accumulation of extracellular matrix (ECM) through myofibroblasts, is a leading cause of mortality worldwide1,2. Understanding the pathways involved in myofibroblasts activation is crucial to develop no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4209ce654b3445165788a67e0ea96ba
https://doi.org/10.1136/annrheumdis-2018-eular.6351

Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice

Autor: Gerard Pasterkamp, Linde Meyaard, Guilielmus H.J.M. Ellenbroek, Fatih Arslan, Bas R van Klarenbosch, Sanne De Jong, Pieter A. Doevendans, Sander M. van de Weg, Imo E. Hoefer, Leo Timmers, Marie-José Goumans, Mirjam B. Smeets, Maike A.D. Brans, Judith J. de Haan, Saskia C.A. de Jager

Publikováno v: Scientific Reports, 7
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, 7(1). Nature Publishing Group
Scientific Reports

Heart failure after myocardial infarction (MI) depends on infarct size and adverse left ventricular (LV) remodelling, both influenced by the inflammatory response. Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) is an inhibitory receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8ce195a08c506128b2d008881e7f18
http://hdl.handle.net/1887/94815