Výsledky vyhledávání - "Judith J Lok"

Akademický článek

CD4 trajectory adjusting for dropout among HIV‐positive patients receiving combination antiretroviral therapy in an East African HIV care centre

Autor: Agnes N Kiragga, Judith J Lok, Beverly S Musick, Ronald J Bosch, Ann Mwangi, Kara K Wools‐Kaloustian, Constantin T Yiannoutsos, for the East Africa IeDEA Regional Consortium

Publikováno v: Journal of the International AIDS Society, Vol 17, Iss 1, Pp n/a-n/a (2014)

Objective Estimates of CD4 response to antiretroviral therapy (ART) obtained by averaging data from patients in care, overestimate population CD4 response and treatment program effectiveness because they do not consider data from patients who are dec

Externí odkaz: https://doaj.org/article/4951f896ddff44ebb30cc3143db05713

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Akademický článek

Predictive value of CD8+ T cell and CD4/CD8 ratio at two years of successful ART in the risk of AIDS and non-AIDS events

Autor: Sergio Serrano-Villar, Kunling Wu, Peter W. Hunt, Judith J. Lok, Raquel Ron, Talía Sainz, Santiago Moreno, Steven G. Deeks, Ronald J. Bosch

Publikováno v: EBioMedicine, Vol 80, Iss , Pp 104072- (2022)

Summary: Background: While increased CD8 counts and low CD4/CD8 ratio during treated HIV correlate with immunosenescence, their additional predictive values to identify individuals with HIV at higher risk of clinical events remain controversial. Meth

Externí odkaz: https://doaj.org/article/46845a22ce724999b2995ed8a25b6709

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Assessing Direct and Spillover Effects of Intervention Packages in Network-Randomized Studies

Autor: Ashley L. Buchanan, Raul Ulises Hernández-Ramírez, Judith J. Lok, Sten H. Vermund, Samuel R. Friedman, Laura Forastiere, Donna Spiegelman

Intervention packages may result in a greater public health impact than single interventions. Understanding the separate impact of each component in the overall package effectiveness can improve intervention delivery. We propose an approach to evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6da35a318a7668e107c259547bc8f0d1
https://doi.org/10.1101/2022.03.24.22272909

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Evaluating the power of the causal impact method in observational studies of HCV treatment as prevention

Autor: Judith J. Lok, Daniela De Angelis, Amy Puenpatom, Frank de Vocht, Pantelis Samartsidis, Sharon J. Hutchinson, Matthew Hickman, Rui Wang, Victor De Gruttola, Natasha Martin

Publikováno v: Samartsidis, P, Martin, N, De Gruttola, V, de Vocht, F, Hutchinson, S, Lok, J J, Puenpatom, A, Wang, R, Hickman, M & De Angelis, D 2021, ' Evaluating the power of the causal impact method in observational studies of HCV treatment as prevention ', Statistical Communications in Infectious Diseases, vol. 13, no. 1 . https://doi.org/10.1515/scid-2020-0005
Stat Commun Infect Dis

Objectives The causal impact method (CIM) was recently introduced for evaluation of binary interventions using observational time-series data. The CIM is appealing for practical use as it can adjust for temporal trends and account for the potential o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612232b77b9cb17474e744667fc585ec
https://hdl.handle.net/1983/322293ea-59ba-4ceb-8638-7be3e5a574ef

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Causal Organic Indirect and Direct Effects: Closer to the Original Approach to Mediation Analysis, with a Product Method for Binary Mediators

Autor: Ronald J. Bosch, Judith J. Lok

Publikováno v: Epidemiology

Mediation analysis, which started in the mid-1980s, is used extensively by applied researchers. Indirect and direct effects are the part of a treatment effect that is mediated by a covariate and the part that is not. Subsequent work on natural indire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968032ee47b88aa21b4d8a7b4691086a
https://pubmed.ncbi.nlm.nih.gov/33783395

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Randomized Trial Evaluating Clinical Impact of RAPid IDentification and Susceptibility Testing for Gram-negative Bacteremia: RAPIDS-GN

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 73, iss 1
Clin Infect Dis

Background Rapid blood culture diagnostics are of unclear benefit for patients with gram-negative bacilli (GNB) bloodstream infections (BSIs). We conducted a multicenter, randomized, controlled trial comparing outcomes of patients with GNB BSIs who h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3ff17d10418350f3218d0cde521f20
https://doi.org/10.1093/cid/ciaa528

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The Impact of Statin and Angiotensin-Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Therapy on Cognitive Function in Adults With Human Immunodeficiency Virus Infection

Autor: Judith J. Lok, Thomas B. Campbell, Jose R Castillo-Mancilla, Kristine M. Erlandson, C. William Wester, Robert C. Kalayjian, Susan L. Koletar, Edgar T. Overton, Douglas Kitch, Constance A. Benson, Kevin Robertson

Publikováno v: Clinical Infectious Diseases. 65:2042-2049

Background Although statins, angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) are generally well tolerated, the impact of these therapies individually or in combination on the change in neurocognitive function in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06c90d14c7e11f7be14b2c5fb0ae286
https://doi.org/10.1093/cid/cix645

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Estimation of the cumulative incidence function under multiple dependent and independent censoring mechanisms

Autor: Michael Hughes, Shu Yang, Judith J. Lok, Brian Sharkey

Publikováno v: Lifetime Data Analysis. 24:201-223

Competing risks occur in a time-to-event analysis in which a patient can experience one of several types of events. Traditional methods for handling competing risks data presuppose one censoring process, which is assumed to be independent. In a contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec2917c78ad83ac43eba00825234777
https://doi.org/10.1007/s10985-017-9393-4

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Sequential, Multiple-Assignment, Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS)

Autor: Thomas L. Holland, Dean Follmann, Robert A. Bonomo, Henry F. Chambers, David L. Paterson, Nadine Rouphael, David van Duin, Helen W. Boucher, Toshimitsu Hamasaki, Vance G. Fowler, Barry N. Kreiswirth, Scott R. Evans, Judith J. Lok, Yunyun Jiang, Thuy Tien T. Tran, Ying Liu, Sarah B Doernberg, Anthony D. Harris

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 68, iss 11

Patient management is not based on a single decision. Rather, it is dynamic: based on a sequence of decisions, with therapeutic adjustments made over time. Adjustments are personalized: tailored to individual patients as new information becomes avail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0185928a2783cae6cbf09936469a52e
https://escholarship.org/uc/item/005884w0

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Variable Selection for Confounder Control, Flexible Modeling and Collaborative Targeted Minimum Loss-Based Estimation in Causal Inference

Autor: Judith J. Lok, Susan Gruber, Mireille E. Schnitzer

Publikováno v: The International Journal of Biostatistics. 12:97-115

This paper investigates the appropriateness of the integration of flexible propensity score modeling (nonparametric or machine learning approaches) in semiparametric models for the estimation of a causal quantity, such as the mean outcome under treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3903789d639c65146f09ed093d17c5c
https://doi.org/10.1515/ijb-2015-0017

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