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IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling
Autor:
Daniel R. Engel, Oliver M. Steinmetz, Athena Chalaris, Jürgen Scheller, Stefan Rose-John, Hans-Willi Mittrücker, Nathalie Jänner, Judith Hoge, Isabell Yan, Valéa Schumacher
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 190(2)
The cytokine IL-6 plays a protective role in immune responses against bacterial infections. However, the mechanisms of IL-6–mediated protection are only partially understood. IL-6 can signal via the IL-6R complex composed of membrane-bound IL-6Rα