Effect of AZD9977 and spironolactone on serum potassium in heart failure with preserved or mildly reduced ejection fraction, and renal impairment: A randomized trial

Autor: Iain B. Squire, Anders Gabrielsen, Peter J. Greasley, Linda Wernevik, Judith Hartleib‐Geschwindner, Julie Holden, Susanne Johansson, Anna Rudvik, José Sánchez, Krister Bamberg, Johanna Melin, Andrew Whittaker

Publikováno v: Clinical and Translational Science, Vol 15, Iss 10, Pp 2493-2504 (2022)

Abstract This phase Ib study compared the effects of AZD9977, a selective mineralocorticoid receptor modulator with predicted low hyperkalemia risk, with spironolactone on serum potassium (sK+) in patients with heart failure (HF) with preserved or mi

Externí odkaz: https://doaj.org/article/2c5d085dcf634af18af1d476fc6a3cbd

Electrolyte handling in the isolated perfused rat kidney: demonstration of vasopressin V2-receptor-dependent calcium reabsorption

Autor: Krister Bamberg, Lena William-Olsson, Ulrika Johansson, Anders Arner, Judith Hartleib-Geschwindner, Johan Sällström

Publikováno v: Upsala Journal of Medical Sciences, Vol 125, Iss 4, Pp 274-280 (2020)

Background The most profound effect of vasopressin on the kidney is to increase water reabsorption through V2-receptor (V2R) stimulation, but there are also data suggesting effects on calcium transport. To address this issue, we have established an i

Externí odkaz: https://doaj.org/article/8b68afb4033f4287a8445a134e515857

Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.

Autor: Krister Bamberg, Ulrika Johansson, Karl Edman, Lena William-Olsson, Susanna Myhre, Anders Gunnarsson, Stefan Geschwindner, Anna Aagaard, Anna Björnson Granqvist, Frédéric Jaisser, Yufeng Huang, Kenneth L Granberg, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0193380 (2018)

Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart failure, but their use is limited due to the compound class-inherent hyperka

Externí odkaz: https://doaj.org/article/837696cf2e364f56bb14da55aad00b11

Electrolyte handling in the isolated perfused rat kidney: demonstration of vasopressin V2-receptor-dependent calcium reabsorption

Autor: Ulrika Johansson, Lena William-Olsson, Anders Arner, Judith Hartleib-Geschwindner, Krister Bamberg, Johan Sällström

Publikováno v: Upsala Journal of Medical Sciences
article-version (VoR) Version of Record
Upsala Journal of Medical Sciences, Vol 125, Iss 4, Pp 274-280 (2020)

Background The most profound effect of vasopressin on the kidney is to increase water reabsorption through V2-receptor (V2R) stimulation, but there are also data suggesting effects on calcium transport. To address this issue, we have established an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1fce007203669c0c32dca710cd0016
http://europepmc.org/articles/PMC7594766

Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection

Autor: Kenneth L. Granberg, Zhong-Qing Yuan, Bo Lindmark, Karl Edman, Johan Kajanus, Anders Hogner, Marcus Malmgren, Gavin O’Mahony, Anneli Nordqvist, Jan Lindberg, Stefan Tångefjord, Michael Kossenjans, Christian Löfberg, Jonas Brånalt, Dongmei Liu, Nidhal Selmi, Grigorios Nikitidis, Peter Nordberg, Ahlke Hayen, Anna Aagaard, Eva Hansson, Majlis Hermansson, Ida Ivarsson, Rasmus Jansson-Löfmark, Ulla Karlsson, Ulrika Johansson, Lena William-Olsson, Judith Hartleib-Geschwindner, Krister Bamberg

Publikováno v: Journal of Medicinal Chemistry. 62:1385-1406

The mechanism-based risk for hyperkalemia has limited the use of mineralocorticoid receptor antagonists (MRAs) like eplerenone in cardio-renal diseases. Here, we describe the structure and property-driven lead generation and optimization, which resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f3415ae30a4bd17f715f083a4fc37e
https://doi.org/10.1021/acs.jmedchem.8b01523