Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Judith G. Levin"'
Publikováno v:
Viruses, Vol 15, Iss 7, p 1549 (2023)
Despite the availability of effective anti-HIV drug therapy, according to UNAIDS estimates, 1 [...]
Externí odkaz:
https://doaj.org/article/ac06a904810d4331b273536e96a048b4
Autor:
Judith G. Levin, Alan Rein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance HIV-1 replication is critically dependent on the selective incorporation of viral RNA genomes into assembling virions. Although RNA elements that promote packaging have been identified, the determinants of authentic packaging fidelity an
Autor:
Chang-Hyeock Byeon, Judith G. Levin, In-Ja L. Byeon, Tiyun Wu, Angela M. Gronenborn, Mithun Mitra, Dustin Singer
Publikováno v:
Biochemistry, vol 55, iss 21
Human APOBEC3B (A3B) is a member of the APOBEC3 (A3) family of cytidine deaminases, which function as DNA mutators and restrict viral pathogens and endogenous retrotransposons. Recently, A3B was identified as a major source of genetic heterogeneity i
Publikováno v:
Virus Research. 193:52-64
The mature HIV-1 nucleocapsid protein (NCp7) is generated by sequential proteolytic cleavage of precursor proteins containing additional C-terminal peptides: NCp15 (NCp7-spacer peptide 2 (SP2)-p6); and NCp9 (NCp7-SP2). Here, we compare the nucleic ac
Autor:
Robert J. Gorelick, Karin Musier-Forsyth, Mark C. Williams, M. Nabuan Naufer, Judith G. Levin, Erik D. Olson, Ioulia Rouzina, Klara Post
Publikováno v:
Retrovirology
Background The nucleocapsid (NC) domain of HIV-1 Gag is responsible for specific recognition and packaging of genomic RNA (gRNA) into new viral particles. This occurs through specific interactions between the Gag NC domain and the Psi packaging signa
Autor:
Karin Musier-Forsyth, Kathy R. Chaurasiya, Mark C. Williams, Wei Wang, Tiyun Wu, Amber Hertz, Dominic F. Qualley, Shingo Kitamura, Ioulia Rouzina, Denise S.B. Chan, Hylkje Geertsema, Judith G. Levin, Yasumasa Iwatani, Micah J. McCauley
Publikováno v:
Nature chemistry
The human APOBEC3 proteins are a family of DNA-editing enzymes that play an important role in the innate immune response and have broad activity against retroviruses and retrotransposons. APOBEC3G is a member of this family that inhibits HIV-1 replic
Autor:
Kathryn Hinchee-Rodriguez, Kamil Hercík, Judith G. Levin, Chang-Hyeock Byeon, Lisa M. Charlton, Gabriel Nam, Angela M. Gronenborn, Mithun Mitra, Gisela Heidecker, In-Ja L. Byeon, Jinwoo Ahn, Dustin Singer, Shawn Hill
Publikováno v:
Nucleic Acids Research
Human APOBEC3A (A3A) is a single-domain cytidine deaminase that converts deoxycytidine residues to deoxyuridine in single-stranded DNA (ssDNA). It inhibits a wide range of viruses and endogenous retroelements such as LINE-1, but it can also edit geno
Publikováno v:
RNA Biology. 7:754-774
The HIV -1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic acid structures so that the most thermodynamically stable conformations are formed. This activity is essential for virus replication and has a critical role in m
Autor:
Robert J. Gorelick, Alan Rein, Tiyun Wu, Judith G. Levin, Mithun Mitra, Siddhartha A. K. Datta
Publikováno v:
Virology
The HIV-1 Gag polyprotein precursor has multiple domains including nucleocapsid (NC). Although mature NC and NC embedded in Gag are nucleic acid chaperones (proteins that remodel nucleic acid structure), few studies include detailed analysis of the c
Autor:
Judith G. Levin, Yasumasa Iwatani, Wataru Sugiura, Junko Shibata, Denise S.B. Chan, Naoki Yamamoto, Hiroaki Yoshii, Lin Liu, Angela M. Gronenborn
Publikováno v:
Proceedings of the National Academy of Sciences. 106:19539-19544
During coevolution with the host, HIV-1 developed the ability to hijack the cellular ubiquitin/proteasome degradation pathway to counteract the antiviral activity of APOBEC3G (A3G), a host cytidine deaminase that can block HIV-1 replication. Abrogati