Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Judith Frydman"'
Autor:
Yingli Gu, Alexander Pope, Charlene Smith, Christopher Carmona, Aaron Johnstone, Linda Shi, Xuqiao Chen, Sarai Santos, Claire Cecile Bacon-Brenes, Thomas Shoff, Korbin M. Kleczko, Judith Frydman, Leslie M. Thompson, William C. Mobley, Chengbiao Wu
Publikováno v:
Neurobiology of Disease, Vol 195, Iss , Pp 106502- (2024)
Synaptic changes are early manifestations of neuronal dysfunction in Huntington's disease (HD). However, the mechanisms by which mutant HTT protein impacts synaptogenesis and function are not well understood. Herein we explored HD pathogenesis in the
Externí odkaz:
https://doaj.org/article/9bef532de4e646788a3015cb4732bb13
Autor:
Junsun Park, Hyunmin Kim, Daniel Gestaut, Seyeon Lim, Kwadwo A. Opoku-Nsiah, Alexander Leitner, Judith Frydman, Soung-Hun Roh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Proper cellular proteostasis, essential for viability, requires a network of chaperones and cochaperones. ATP-dependent chaperonin TRiC/CCT partners with cochaperones prefoldin (PFD) and phosducin-like proteins (PhLPs) to facilitate folding
Externí odkaz:
https://doaj.org/article/b8cf75b24bd047c984b11ca0f74486ab
Autor:
Ranen Aviner, Peter V Lidsky, Yinghong Xiao, Michel Tassetto, Damian Kim, Lichao Zhang, Patrick L McAlpine, Joshua Elias, Judith Frydman, Raul Andino
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011535 (2024)
A better mechanistic understanding of virus-host dependencies can help reveal vulnerabilities and identify opportunities for therapeutic intervention. Of particular interest are essential interactions that enable production of viral proteins, as thos
Externí odkaz:
https://doaj.org/article/4f949c539917425396f505f21d021d7c
Autor:
Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cathy Hou, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a genetic mutation in the huntingtin gene (HTT). Here, cryo electron tomography provides insights into the morphology of the cells derived from patients with HD and mouse mod
Externí odkaz:
https://doaj.org/article/27dd4928dbf643889186e8bd55e8a97e
Publikováno v:
Argentinian Journal of Respiratory and Physical Therapy, Vol 5, Iss 2 (2023)
Objetivo: Describir las características clínico-demográficas de sujetos pediátricos con enfermedad respiratoria internados en sala de un hospital municipal de la provincia de Buenos Aires durante la pandemia por COVID-19 (2020-2021) y los períod
Externí odkaz:
https://doaj.org/article/9c18d48d631849aea296cf3bf6042b4e
Publikováno v:
Argentinian Journal of Respiratory and Physical Therapy, Vol 5, Iss 1 (2023)
Objetivo: Describir las características clínico-demográficas de sujetos pediátricos críticos crónicos internados en un centro de desvinculación de ventilación mecánica. El objetivo secundario consiste en describir la tasa de éxito de desvin
Externí odkaz:
https://doaj.org/article/73374c31d532402ea0a3b211cc517e01
Autor:
Rebekah C. Gullberg, Judith Frydman
Publikováno v:
Viruses, Vol 15, Iss 6, p 1335 (2023)
SARS-CoV-2 is a positive-strand RNA virus in the Coronaviridae family that is responsible for morbidity and mortality worldwide. To better understand the molecular pathways leading to SARS-CoV-2 virus assembly, we examined a virus-like particle (VLP)
Externí odkaz:
https://doaj.org/article/0fc40df2c43d49a2a0820a2b03fec917
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The mechanism by which chaperonins coordinate ATP utilization in their multiple subunits remains unclear. Here, the authors employ an approach that uses cryo-EM single particle analysis to track the number and distribution of nucleotides bound to eac
Externí odkaz:
https://doaj.org/article/8c38f29ae54c40088fd5bbdd48cbf038
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Galaz-Montoya et al. report nanometer-resolution 3D cryo-electron tomography structures of mutant huntingtin (mHTT) and polyglutamine-only (polyQ) filaments in large aggregates free of stains, fixatives, tags, or dehydration artifacts. These results
Externí odkaz:
https://doaj.org/article/ea1f2eddaca54466aca9f8f300dddd4e
Autor:
Miranda P. Collier, Karen Betancourt Moreira, Kathy H. Li, Yu-Chan Chen, Daniel Itzhak, Rahul Samant, Alexander Leitner, Alma Burlingame, Judith Frydman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The eukaryotic chaperonin TRiC/CCT is a large ATP-dependent complex essential for cellular protein folding. Its subunit arrangement into two stacked eight-membered hetero-oligomeric rings is conserved from yeast to man. A recent breakthrough
Externí odkaz:
https://doaj.org/article/17df211e25b3430283c572003e4f16b8