Cell lineage analysis of the mammalian female germline.

Autor: Yitzhak Reizel, Shalev Itzkovitz, Rivka Adar, Judith Elbaz, Adrian Jinich, Noa Chapal-Ilani, Yosef E Maruvka, Nava Nevo, Zipora Marx, Inna Horovitz, Adam Wasserstrom, Avi Mayo, Irena Shur, Dafna Benayahu, Karl Skorecki, Eran Segal, Nava Dekel, Ehud Shapiro

Publikováno v: PLoS Genetics, Vol 8, Iss 2, p e1002477 (2012)

Fundamental aspects of embryonic and post-natal development, including maintenance of the mammalian female germline, are largely unknown. Here we employ a retrospective, phylogenetic-based method for reconstructing cell lineage trees utilizing somati

Externí odkaz: https://doaj.org/article/5efcf0bb926341b8a48eac6b4c915a81

Highly efficient reprogrammable mouse lines with integrated reporters to track the route to pluripotency

Autor: Judith Elbaz, Mira C. Puri, Maryam Faiz, K. W. Annie Bang, Lena Nguyen, Bar Makovoz, Marina Gertsenstein, Samer M. I. Hussein, Peter W. Zandstra, Laurent Briollais, Nika Shakiba, Andras Nagy

Publikováno v: Proceedings of the National Academy of Sciences. 119

Revealing the molecular events associated with reprogramming different somatic cell types to pluripotency is critical for understanding the characteristics of induced pluripotent stem cell (iPSC) therapeutic derivatives. Inducible reprogramming facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e412902cd5821a0a0a0146c3b26c54ea
https://doi.org/10.1073/pnas.2207824119

Cell competition during reprogramming gives rise to dominant clones

Autor: Peter W. Zandstra, Nika Shakiba, Laurent David, Gowtham Jayakumaran, Daniel Trcka, Derek van der Kooy, Andras Nagy, Judith Elbaz, Mira C. Puri, Ahmed Fahmy, Sidhartha Goyal, Sophie McGibbon, Jeffrey L. Wrana

Publikováno v: Science
Science, 2019, 364 (6438), Epub 2019 Mar 21. ⟨10.1126/science.aan0925⟩
Science, American Association for the Advancement of Science, 2019, 364 (6438), Epub 2019 Mar 21. ⟨10.1126/science.aan0925⟩

Domination in the stem cell world A Nobel Prize–winning discovery showed that specialized cells can be genetically reprogrammed into stem cells, thus gaining the ability to become any cell type in the body. But what happens during reprogramming is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4dafa5e7b79837a86e1094035d1a9d
https://www.hal.inserm.fr/inserm-02145973/document

Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC: a retrospective chart review (REFLECT)

Autor: Andriani Charpidou, Jorgen Aaroe, Urska Janzic, Tudor Ciuleanu, Judith Elbaz, Alfredo Addeo, Adam Płużanński, Nir Peled, Ivan Shterev Donev, Elizabeth Dudnik, Maximilian Hochmair, René Ott

Publikováno v: Therapeutic advances in medical oncology, vol. 13, pp. 1-11, 2021.
Therapeutic Advances in Medical Oncology, Vol 13 (2021)

Introduction: For epidermal growth factor receptor mutation-positive (EGFRm) non-small-cell lung cancer (NSCLC), EGFR-tyrosine kinase inhibitors (EGFR-TKIs) are the preferred first-line (1 L) treatment in the advanced setting. Osimertinib, a third-ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4aec7e2c185f427da5dab3ae8e7cd2
https://doi.org/10.1177/17588359211059874

Genome damage in induced pluripotent stem cells: Assessing the mechanisms and their consequences

Autor: Samer M.I. Hussein, Judith Elbaz, Andras Nagy

Publikováno v: BioEssays. 35:152-162

In 2006, Shinya Yamanaka and colleagues discovered how to reprogram terminally differentiated somatic cells to a pluripotent stem cell state. The resulting induced pluripotent stem cells (iPSCs) made a paradigm shift in the field, further nailing dow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034ffa9ba1b5952b920431fc5401148c
https://doi.org/10.1002/bies.201200114