A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

Autor: Lin Zhou, Siqi Zheng, Fernando R Rosas Bringas, Bjorn Bakker, Judith E Simon, Petra L Bakker, Hinke G Kazemier, Michael Schubert, Maurits Roorda, Marcel A T M van Vugt, Michael Chang, Floris Foijer

Publikováno v: G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)

AbstractMaternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemoth

Externí odkaz: https://doaj.org/article/47ad807053204d65be2ed713aa553e49

A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

Autor: Maurits Roorda, Michael Schubert, Petra L. Bakker, Michael Chang, Marcel A. T. M. van Vugt, Bjorn Bakker, Lin Zhou, Judith E Simon, Hinke G. Kazemier, Fernando R. Rosas Bringas, Siqi Zheng, Floris Foijer

Publikováno v: G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
G3 : Genes, Genomes, Genetics, 11(12):335. GENETICS SOCIETY AMERICA
G3: Genes|Genomes|Genetics

Maternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemotherapy re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67847db3e824bd4fd11a7ca111401a5a
https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab335

Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition

Autor: Petra L. Bakker, Klaske M. Schukken, Yu-Chih Lin, Zuzana Storchova, Stephanie F. Preuss, Michael Schubert, Maria Colomé-Tatché, Diana C.J. Spierings, Judith E Simon, Floris Foijer, Hilda van den Bos, Holger Bastians

Publikováno v: Life science alliance, 3(2):e201900499. Life Science Alliance LLC
Life Sci. All. 3:e201900499 (2020)
Life Science Alliance

Chromosomal instability (CIN) is a hallmark feature of cancer cells. In this study, Schukken and colleagues screen for compounds that selectively target CIN cells and identify an inhibitor of Src kinase to be selectively toxic for CIN cells.
Chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1bb77de7f484944d83579f4509eff5
https://research.rug.nl/en/publications/35f9af62-0640-4ff4-9c72-3802f77f81d4

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress

Autor: Jos Jonkers, Stephanie H. Davis, Nathalie Conte, Allan Bradley, Peter K. Sorger, Stephanie Z. Xie, Petra L. Bakker, Eva Kregel, Judith E Simon, Floris Foijer

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 111(37), 13427-13432. NATL ACAD SCIENCES

Aneuploidy is a hallmark of human solid cancers that arises from errors in mitosis and results in gain and loss of oncogenes and tumor suppressors. Aneuploidy poses a growth disadvantage for cells grown in vitro, suggesting that cancer cells adapt to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc542f56945b7b421a1a0bcccce397d
https://hdl.handle.net/11370/b356c578-46d1-46ff-bbf1-6276a0e24bb8

A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset

Autor: Viji M. Draviam, Rajesh T. Shenoy, Noriko Hiroi, Naoka Tamura, Akira Funahashi, Judith E Simon, Viviane Boilot, Arnab Nayak

Publikováno v: Biology Open
Biology Open, Vol 4, Iss 2, Pp 155-169 (2015)

Microtubules execute diverse mitotic events that are spatially and temporally separated; the underlying regulation is poorly understood. By combining drug treatments, large-scale immunoprecipitation and mass spectrometry, we report the first comprehe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a2a2a0316a25bd061b1dd6c5376640
https://pubmed.ncbi.nlm.nih.gov/25596275