Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Judith E Allen"'
Autor:
Ruth Forman, Larisa Logunova, Hannah Smith, Kelly Wemyss, Iris Mair, Louis Boon, Judith E Allen, Werner Muller, Joanne L Pennock, Kathryn J Else
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009768 (2021)
The intestinal nematode parasite Trichuris muris dwells in the caecum and proximal colon driving an acute resolving intestinal inflammation dominated by the presence of macrophages. Notably, these macrophages are characterised by their expression of
Externí odkaz:
https://doaj.org/article/c66c777140c7426f8f87146164ffbd92
Autor:
Tara E Sutherland, Dominik Rückerl, Nicola Logan, Sheelagh Duncan, Thomas A Wynn, Judith E Allen
Publikováno v:
PLoS Pathogens, Vol 14, Iss 11, p e1007423 (2018)
Ym1 and RELMα are established effector molecules closely synonymous with Th2-type inflammation and associated pathology. Here, we show that whilst largely dependent on IL-4Rα signaling during a type 2 response, Ym1 and RELMα also have IL-4Rα-inde
Externí odkaz:
https://doaj.org/article/e2b096516e3548049c1a7dcaada07761
Autor:
Joseph D Turner, Nicolas Pionnier, Julio Furlong-Silva, Hanna Sjoberg, Stephen Cross, Alice Halliday, Ana F Guimaraes, Darren A N Cook, Andrew Steven, Nico Van Rooijen, Judith E Allen, Stephen J Jenkins, Mark J Taylor
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006949 (2018)
Eosinophils are effectors in immunity to tissue helminths but also induce allergic immunopathology. Mechanisms of eosinophilia in non-mucosal tissues during infection remain unresolved. Here we identify a pivotal function of tissue macrophages (Mϕ)
Externí odkaz:
https://doaj.org/article/89105a4f1ac8479982a358d3bd651ce1
Autor:
Sharon M Campbell, Johanna A Knipper, Dominik Ruckerl, Conor M Finlay, Nicola Logan, Carlos M Minutti, Matthias Mack, Stephen J Jenkins, Matthew D Taylor, Judith E Allen
Publikováno v:
eLife, Vol 7 (2018)
Both TH2-dependent helminth killing and suppression of the TH2 effector response have been attributed to macrophages (MΦ) activated by IL-4 (M(IL-4)). To investigate how M(IL-4) contribute to diverse infection outcomes, the MΦ compartment of suscep
Externí odkaz:
https://doaj.org/article/4c578b58c36d4161bffcb945f1e552eb
Autor:
Dominik Rückerl, Sharon M Campbell, Sheelagh Duncan, Tara E Sutherland, Stephen J Jenkins, James P Hewitson, Tom A Barr, Lucy H Jackson-Jones, Rick M Maizels, Judith E Allen
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006233 (2017)
Rapid reprogramming of the macrophage activation phenotype is considered important in the defense against consecutive infection with diverse infectious agents. However, in the setting of persistent, chronic infection the functional importance of macr
Externí odkaz:
https://doaj.org/article/13c5789c28094405a1f784be2bdd5dc5
Autor:
James P Hewitson, Dominik Rückerl, Yvonne Harcus, Janice Murray, Lauren M Webb, Simon A Babayan, Judith E Allen, Agnes Kurniawan, Rick M Maizels
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003930 (2014)
Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects. Microfilariae are produced by long-lived adult parasites, which also release a suite o
Externí odkaz:
https://doaj.org/article/4c54e2a2d7ba49e7807c746ad092190c
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 12, p e1968 (2012)
Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the efficacy of a va
Externí odkaz:
https://doaj.org/article/63e6b2a7c6044c978a2aca9520f41fda
Autor:
Laura J Appleby, Norman Nausch, Claire D Bourke, Nadine Rujeni, Nicholas Midzi, Takafira Mduluza, Judith E Allen, Francisca Mutapi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1898 (2012)
Currently there are few studies characterising the nature and aetiology of human schistosome-related inflammatory processes. The aim of this study was to determine the relationship between Chitinase 3-like 1 (CHI3L1), also known as YKL-40, a molecule
Externí odkaz:
https://doaj.org/article/84c15268a2a345969fdd2696d8d3c5dc
Autor:
Judith E Allen, Thomas A Wynn
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002003 (2011)
Externí odkaz:
https://doaj.org/article/1e5512b787704234afc44c80bb98d1bd
Publikováno v:
PLoS Biology, Vol 8, Iss 10, p e1000525 (2010)
Humans and other mammals mount vigorous immune assaults against helminth parasites, yet there are intriguing reports that the immune response can enhance rather than impair parasite development. It has been hypothesized that helminths, like many free
Externí odkaz:
https://doaj.org/article/558055484b464856adf5661e7544a897