Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Judith C. Hamel"'
Autor:
John Schafer, Michael A. Plotkin, Xiaoyuan Ding, Todd Wisialowski, Meghan Maloney, Judith C. Hamel, Sandra P. McCurdy, Joel R. Hardink, Christopher Zook, Steven M. Finegan, Chakrapani Subramanyam, Lori Brennan, Rose Barham, Steven J. Brickner, Daniel P. Uccello, Dale Gordon Mcleod, Kwansik Yoon, Michael D. Huband, Jeffrey M. Casavant, Usa Reilly, Mark J. Mitton-Fry, Anthony Marfat, Richard P. Zaniewski, Gregory G. Stone, Thuy Hoang
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(15)
Novel (non-fluoroquinolone) inhibitors of bacterial type II topoisomerases (NBTIs) are an emerging class of antibacterial agents. We report an optimized series of cyclobutylaryl-substituted NBTIs. Compound 14 demonstrated excellent activity both in v
Autor:
Betty H. Yagi, Judith C. Hamel, Judy K. Moerman, Ronda D. Schaadt, Gary E. Zurenko, Douglas Stapert, Paul Adrian Aristoff, Paul D. Johnson, Ford Charles W
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4197-4200
Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined.
Autor:
Richard C. Thomas, Matthew J Zaya, Barbachyn Michael R, Wade J. Adams, Betty H. Yagi, Michael A. Wynalda, J P Sams, Larry C. Wienkers, Ford Charles W, J Gregory Slatter, Nancee L. Oien, William Watt, Eric P. Seest, Janice M. Friis, Joel Morris, Judith C. Hamel, Gary E. Zurenko, Lester A. Dolak, Ronda D. Schaadt, Douglas Stapert, Cleek Gary J, Donn G. Wishka, Stuart A. Garmon, Toops Dana S
Publikováno v:
Journal of Medicinal Chemistry. 46:284-302
A new and promising group of antibacterial agents, collectively known as the oxazolidinones and exemplified by linezolid (PNU-100766, marketed as Zyvox), have recently emerged as important new therapeutic agents for the treatment of infections caused
Autor:
Gary E. Zurenko, Betty H. Yagi, Douglas K Hutchinson, D E Emmert, David R. Graber, Jackson B. Hester, Stuart A. Garmon, Judith C. Hamel, Michael R Barbachyn, Ronda D. Schaadt, Michael J. Genin, Douglas Stapert, Joel Morris, David J. Anderson, Debra A. Allwine, R J Reischer, Charles W. Ford, Kevin C. Grega
Publikováno v:
Journal of Medicinal Chemistry. 43:953-970
A series of new nitrogen-carbon-linked (azolylphenyl)oxazolidinone antibacterial agents has been prepared in an effort to expand the spectrum of activity of this class of antibiotics to include Gram-negative organisms. Pyrrole, pyrazole, imidazole, t
Publikováno v:
Infection. 28:60-64
In spite of a constantly expanding information base with the oxazolidinones generally and linezolid specifically, we have elected here to focus on the key characteristics of linezolid. Linezolid is the first member of a new class of antimicrobial age
Autor:
Charles W. Ford, Gary E. Zurenko, Hutchinson Douglas K, Betty H. Yagi, Janice M. Friis, D E Emmert, Michael J. Genin, Shobe Em, Jackson B. Hester, Stuart A. Garmon, Debra A. Allwine, Wade J. Adams, Ronda D. Schaadt, Judith C. Hamel, Douglas Stapert
Publikováno v:
Journal of Medicinal Chemistry. 41:5144-5147
Autor:
Judith C. Hamel, Judy K. Moerman, Barbachyn Michael R, Gary E. Zurenko, Ford Charles W, Douglas Stapert, Hutchinson Douglas K
Publikováno v:
Trends in Microbiology. 5:196-200
The oxazolidinones are a new chemical class of synthetic antibacterial agents that are active orally or intravenously against multidrug-resistant Gram-positive bacteria. Their unique mechanism of action and activity against bacteria that pose therape
Autor:
James P. Driscoll, Kwansik Yoon, Sandra P. McCurdy, Joel R. Hardink, Xiaoyuan Ding, Wei Yuan, Erbing Hua, Christopher Zook, Michael A. Plotkin, James F. Smith, Tao Chen, Steven J. Brickner, Meghan Maloney, Lori Brennan, Dale Gordon Mcleod, Anthony Marfat, Jeffrey M. Casavant, Richard M. Shepard, John Schafer, Usa Reilly, Shaughn Robinson, Judith C. Hamel, Chakrapani Subramanyam, Mark J. Mitton-Fry, Michael D. Huband, Michael Chen, Gregory G. Stone, Thuy Hoang, Richard P. Zaniewski
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(10)
A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.
Autor:
Betty H. Yagi, Suzanne E. Glickman, Susan K. Hendges, Ford Charles W, Toops Dana S, Jonda D. Schaadt, Barbachyn Michael R, Douglas Stapert, Kevin C. Grega, Jerry M. Buysse, Judith C. Hamel, James O. Kilburn, Gary E. Zurenko, William F. Demyan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1009-1014
Various electron-withdrawing groups were incorporated into the meta position of tropone-substituted 3-phenyl-2-oxazolidinones and their influence on antibacterial activity examined. Consideration of in vitro and in vivo test results indicated that on
Autor:
Betty H. Yagi, Kevin C. Grega, Ronda D. Schaadt, W. F. Demyan, Toops Dana S, Gary E. Zurenko, Steven J. Brickner, J. O. Kilburn, Barbachyn Michael R, Debra A. Ulanowicz, Ford Charles W, S. E. Glickman, Judith C. Hamel, J. M. Buysse, Douglas Stapert
Publikováno v:
ChemInform. 27