Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Judith C. Fleming"'
Autor:
David J. Witter, Karin M. Otte, Richard E. Middleton, Bethany Hughes, Jonathan B. Grimm, Alexander A. Szewczak, Phieng Siliphaivanh, Julie E. Hamill, Judith C. Fleming, Jonathan C. Cruz, Melissa Chenard, Astrid M. Kral, William K. Dahlberg, Kevin J. Wilson, J. Paul Secrist, Thomas A. Miller, Andreas Harsch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1859-1863
An HTS screening campaign identified a series of low molecular weight phenols that showed excellent selectivity (>100-fold) for HDAC1/HDAC2 over other Class I and Class II HDACs. Evolution and optimization of this HTS hit series provided HDAC1-select
Autor:
Thomas A. Miller, Astrid M. Kral, Richard E. Middleton, J. Paul Secrist, Jed L. Hubbs, Bethany Hughes, William K. Dahlberg, Hua Zhou, Alexander A. Szewczak, Judith C. Fleming
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:34-38
Ongoing clinical studies indicate that inhibitors of Class I and Class II histone deacetylase (HDAC) enzymes show great promise for the treatment of cancer. Zolinza® (SAHA, Zolinza®) was recently approved by the FDA for the treatment of the cutaneo
Autor:
Brian B. Haines, Judith C. Fleming, Joon Jung, Paul Secrist, Hongmei Wang, Thomas A. Miller, Richard W. Heidebrecht, Paul Harrington, Joshua Close, Nicole Ozerova, John Maclean, Melissa Chenard, Astrid M. Kral
Publikováno v:
Biochemistry. 53(4)
Histone deacetylases (HDACs) play diverse roles in many diseases including cancer, sarcopenia, and Alzheimer’s. Different isoforms of HDACs appear to play disparate roles in the cell and are associated with specific diseases; as such, a substantial
Autor:
Matthew G. Stanton, David J. Witter, Christopher Hamblett, Nicole Ozerova, Brian B. Haines, Richard E. Middleton, Judith C. Fleming, Phieng Siliphaivanh, Dawn Marie Mampreian Hoffman, Hongmei Wang, Alexander A. Szewczak, Jed L. Hubbs, Melissa Chenard, Astrid M. Kral, Bethany Hughes, Kevin J. Wilson, Paul Harrington, J. Paul Secrist, Richard W. Heidebrecht, Joey L. Methot, Thomas A. Miller, Jonathan C. Cruz, Andreas Harsch, Candia M. Kenific
The identification and in vitro and in vivo characterization of a potent SHI-1:2 are described. Kinetic analysis indicated that biaryl inhibitors exhibit slow binding kinetics in isolated HDAC1 and HDAC2 preparations. Delayed histone hyperacetylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe238132473cf3e20a702fe00be4018
https://europepmc.org/articles/PMC4027730/
https://europepmc.org/articles/PMC4027730/
Autor:
Souheil Omar, Ali Belhani, Mongi Hamdi, Judith C. Fleming, Charles I. Berul, Ellis J. Neufeld, Mara P. Steinkamp, Raouf Hafsia, Elena Tartaglini, Sarrah Baltagi-Ben Jilani, Sami Gritli, Souha Guannouni
Publikováno v:
British Journal of Haematology. 113:508-513
Thiamine-responsive megaloblastic anaemia (TRMA) syndrome with diabetes and deafness was found in two patients from a Tunisian kindred. The proband was homozygous for a novel mutation, 287delG, in the high-affinity thiamine transporter gene, SLC19A2.
Publikováno v:
Blood Cells, Molecules, and Diseases. 27:135-138
Thiamine-responsive megaloblastic anemia (TRMA) syndrome (OMIM No. 249270) comprises a distinctive triad of clinical features: megaloblastic anemia with ringed sideroblasts, diabetes mellitus, and progressive sensorineural deafness. The TRMA gene has
Autor:
Mara P. Steinkamp, Elena Tartaglini, Judith C. Fleming, Daniel F. Schorderet, Ellis J. Neufeld, Nadine Cohen
Publikováno v:
Nature Genetics. 22:305-308
Thiamine-responsive megaloblastic anaemia with diabetes and deafness1 (TRMA; MIM 249270) is an autosomal recessive disease thought to be due to a defect in thiamine (vitamin B1) transport2,3. Pharmacological doses of thiamine correct the anaemia, and
Autor:
Ellis J. Neufeld, Judith C. Fleming, Amy Stagg, Massayuki Sakamoto, Meghan A Baker, Nadine Cohen
Publikováno v:
Journal of Clinical Investigation. 103:723-729
We have investigated the cellular pathology of the syndrome called thiamine-responsive megaloblastic anemia (TRMA) with diabetes and deafness. Cultured diploid fibroblasts were grown in thiamine-free medium and dialyzed serum. Normal fibroblasts surv
Publikováno v:
Blood. 92:2157-2163
Microcytic anemia (mk) mice and Belgrade (b) rats have severe iron deficiency anemia due to defects in intestinal iron transport and erythroid iron utilization. Both animal mutants carry the same missense mutation in Nramp2, the first mammalian iron
Autor:
Julie E. Hamill, Nicole Ozerova, Hongmei Wang, David J. Witter, Alexander A. Szewczak, Richard W. Heidebrecht, Brian B. Haines, Andreas Harsch, Richard E. Middleton, Judith C. Fleming, Chandrasekhar Mushti, Joshua Close, Jonathan B. Grimm, Melissa Chenard, Astrid M. Kral, Kevin J. Wilson, J. Paul Secrist, Thomas A. Miller, William K. Dahlberg, Bethany Hughes
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(7)
We report the preparation and structure-activity relationships of phosphorus-containing histone deacetylase inhibitors. A strong trend between decreasing phosphorus functional group size and superior mouse pharmacokinetic properties was identified. I