Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Autor: Jiang Ren, Judith Bruns, Peter Lindemann, Kathrin Motzny, Ronald Kühne, Slim Chiha, Matthias M. Müller, Monika Beerbaum, Robert Opitz, Stephan Dohmen, Matthias Barone, Arne Soicke, Marco Tobias Klein, Dominik Albat, Peter Schmieder, Udo Heinemann, Hartmut Oschkinat, Yvette Roske, Marc Nazaré, Hans-Günther Schmalz, Peter ten Dijke, Rudolf Volkmer, Maarten van Dinther

Publikováno v: Proceedings of the National Academy of Sciences, 117(47), 29684-29690. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America

Significance Protein–protein interactions mediated by proline-rich motifs are involved in regulation of many important signaling cascades. These motifs belong to the most abundant recognition motifs in the eukaryotic genome and preferentially adopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3f020fdbbb67aa9a4b024f1290a866
https://hdl.handle.net/1887/3185199